Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease

Autores
Urbina, J.A.; Concepcion, J.L.; Montalvetti, A.; Rodriguez, J.B.; Docampo, R.
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
Fuente
Antimicrob. Agents Chemother. 2003;47(6):2047-2050
Materia
4 phenoxyphenoxyethyl thiocyanate
antiprotozoal agent
squalene synthase
sterol
unclassified drug
wc 9
antiprotozoal activity
article
Chagas disease
controlled study
drug activity
drug mechanism
epimastigote
growth inhibition
nonhuman
priority journal
sterol synthesis
Trypanosoma cruzi
Alkyl and Aryl Transferases
Animals
Dose-Response Relationship, Drug
Ergosterol
Farnesyl-Diphosphate Farnesyltransferase
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Phenyl Ethers
Thiocyanates
Trypanocidal Agents
Trypanosoma cruzi
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/2.5/ar
Repositorio
Biblioteca Digital (UBA-FCEN)
Institución
Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
OAI Identificador
paperaa:paper_00664804_v47_n6_p2047_Urbina
Acceder
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oai_identifier_str paperaa:paper_00664804_v47_n6_p2047_Urbina
network_acronym_str BDUBAFCEN
repository_id_str 1896
network_name_str Biblioteca Digital (UBA-FCEN)
spelling Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' diseaseUrbina, J.A.Concepcion, J.L.Montalvetti, A.Rodriguez, J.B.Docampo, R.4 phenoxyphenoxyethyl thiocyanateantiprotozoal agentsqualene synthasesterolunclassified drugwc 9antiprotozoal activityarticleChagas diseasecontrolled studydrug activitydrug mechanismepimastigotegrowth inhibitionnonhumanpriority journalsterol synthesisTrypanosoma cruziAlkyl and Aryl TransferasesAnimalsDose-Response Relationship, DrugErgosterolFarnesyl-Diphosphate FarnesyltransferaseGeranyltranstransferaseHumansMicrobial Sensitivity TestsPhenyl EthersThiocyanatesTrypanocidal AgentsTrypanosoma cruziWe investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_UrbinaAntimicrob. Agents Chemother. 2003;47(6):2047-2050reponame:Biblioteca Digital (UBA-FCEN)instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesinstacron:UBA-FCENenginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/2.5/ar2025-09-18T10:09:17Zpaperaa:paper_00664804_v47_n6_p2047_UrbinaInstitucionalhttps://digital.bl.fcen.uba.ar/Universidad públicaNo correspondehttps://digital.bl.fcen.uba.ar/cgi-bin/oaiserver.cgiana@bl.fcen.uba.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:18962025-09-18 10:09:18.239Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturalesfalse
dc.title.none.fl_str_mv Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
spellingShingle Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
Urbina, J.A.
4 phenoxyphenoxyethyl thiocyanate
antiprotozoal agent
squalene synthase
sterol
unclassified drug
wc 9
antiprotozoal activity
article
Chagas disease
controlled study
drug activity
drug mechanism
epimastigote
growth inhibition
nonhuman
priority journal
sterol synthesis
Trypanosoma cruzi
Alkyl and Aryl Transferases
Animals
Dose-Response Relationship, Drug
Ergosterol
Farnesyl-Diphosphate Farnesyltransferase
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Phenyl Ethers
Thiocyanates
Trypanocidal Agents
Trypanosoma cruzi
title_short Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_full Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_fullStr Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_full_unstemmed Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
title_sort Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease
dc.creator.none.fl_str_mv Urbina, J.A.
Concepcion, J.L.
Montalvetti, A.
Rodriguez, J.B.
Docampo, R.
author Urbina, J.A.
author_facet Urbina, J.A.
Concepcion, J.L.
Montalvetti, A.
Rodriguez, J.B.
Docampo, R.
author_role author
author2 Concepcion, J.L.
Montalvetti, A.
Rodriguez, J.B.
Docampo, R.
author2_role author
author
author
author
dc.subject.none.fl_str_mv 4 phenoxyphenoxyethyl thiocyanate
antiprotozoal agent
squalene synthase
sterol
unclassified drug
wc 9
antiprotozoal activity
article
Chagas disease
controlled study
drug activity
drug mechanism
epimastigote
growth inhibition
nonhuman
priority journal
sterol synthesis
Trypanosoma cruzi
Alkyl and Aryl Transferases
Animals
Dose-Response Relationship, Drug
Ergosterol
Farnesyl-Diphosphate Farnesyltransferase
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Phenyl Ethers
Thiocyanates
Trypanocidal Agents
Trypanosoma cruzi
topic 4 phenoxyphenoxyethyl thiocyanate
antiprotozoal agent
squalene synthase
sterol
unclassified drug
wc 9
antiprotozoal activity
article
Chagas disease
controlled study
drug activity
drug mechanism
epimastigote
growth inhibition
nonhuman
priority journal
sterol synthesis
Trypanosoma cruzi
Alkyl and Aryl Transferases
Animals
Dose-Response Relationship, Drug
Ergosterol
Farnesyl-Diphosphate Farnesyltransferase
Geranyltranstransferase
Humans
Microbial Sensitivity Tests
Phenyl Ethers
Thiocyanates
Trypanocidal Agents
Trypanosoma cruzi
dc.description.none.fl_txt_mv We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
description We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina
url http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/2.5/ar
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Antimicrob. Agents Chemother. 2003;47(6):2047-2050
reponame:Biblioteca Digital (UBA-FCEN)
instname:Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron:UBA-FCEN
reponame_str Biblioteca Digital (UBA-FCEN)
collection Biblioteca Digital (UBA-FCEN)
instname_str Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
instacron_str UBA-FCEN
institution UBA-FCEN
repository.name.fl_str_mv Biblioteca Digital (UBA-FCEN) - Universidad Nacional de Buenos Aires. Facultad de Ciencias Exactas y Naturales
repository.mail.fl_str_mv ana@bl.fcen.uba.ar
_version_ 1843608735957647360
score 13.001348

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