Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model

Autores
Bierbrauer, Karina Lilian; Alasino, Roxana Valeria; Barclay, Fernando E.; Belotti, Eduardo Matías; Ortega, Hugo Hector; Beltramo, Dante Miguel
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.
Fil: Bierbrauer, Karina Lilian. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alasino, Roxana Valeria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barclay, Fernando E.. Instituto Argentino de Diagnóstico y Tratamiento, Ortopedia y Traumatología, Cirugía Artroscópica y Medicina del Deporte; Argentina
Fil: Belotti, Eduardo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; Argentina
Fil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CHONDROITIN SULFATE
HYDROGEL
INTRA-ARTICULAR IMPLANT
OSTEOARTHRITIS
POLYQUATERNIUM-10
RABBIT MODEL
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157820
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/157820
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit modelBierbrauer, Karina LilianAlasino, Roxana ValeriaBarclay, Fernando E.Belotti, Eduardo MatíasOrtega, Hugo HectorBeltramo, Dante MiguelCHONDROITIN SULFATEHYDROGELINTRA-ARTICULAR IMPLANTOSTEOARTHRITISPOLYQUATERNIUM-10RABBIT MODELhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.Fil: Bierbrauer, Karina Lilian. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Alasino, Roxana Valeria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barclay, Fernando E.. Instituto Argentino de Diagnóstico y Tratamiento, Ortopedia y Traumatología, Cirugía Artroscópica y Medicina del Deporte; ArgentinaFil: Belotti, Eduardo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; ArgentinaFil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; ArgentinaFil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMDPI2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157820Bierbrauer, Karina Lilian; Alasino, Roxana Valeria; Barclay, Fernando E.; Belotti, Eduardo Matías; Ortega, Hugo Hector; et al.; Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model; MDPI; Polymers; 13; 24; 12-2021; 1-192073-4360CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/13/24/4426info:eu-repo/semantics/altIdentifier/doi/10.3390/polym13244426info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:04Zoai:ri.conicet.gov.ar:11336/157820instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:04.367CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
title Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
spellingShingle Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
Bierbrauer, Karina Lilian
CHONDROITIN SULFATE
HYDROGEL
INTRA-ARTICULAR IMPLANT
OSTEOARTHRITIS
POLYQUATERNIUM-10
RABBIT MODEL
title_short Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
title_full Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
title_fullStr Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
title_full_unstemmed Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
title_sort Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model
dc.creator.none.fl_str_mv Bierbrauer, Karina Lilian
Alasino, Roxana Valeria
Barclay, Fernando E.
Belotti, Eduardo Matías
Ortega, Hugo Hector
Beltramo, Dante Miguel
author Bierbrauer, Karina Lilian
author_facet Bierbrauer, Karina Lilian
Alasino, Roxana Valeria
Barclay, Fernando E.
Belotti, Eduardo Matías
Ortega, Hugo Hector
Beltramo, Dante Miguel
author_role author
author2 Alasino, Roxana Valeria
Barclay, Fernando E.
Belotti, Eduardo Matías
Ortega, Hugo Hector
Beltramo, Dante Miguel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CHONDROITIN SULFATE
HYDROGEL
INTRA-ARTICULAR IMPLANT
OSTEOARTHRITIS
POLYQUATERNIUM-10
RABBIT MODEL
topic CHONDROITIN SULFATE
HYDROGEL
INTRA-ARTICULAR IMPLANT
OSTEOARTHRITIS
POLYQUATERNIUM-10
RABBIT MODEL
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.
Fil: Bierbrauer, Karina Lilian. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Alasino, Roxana Valeria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barclay, Fernando E.. Instituto Argentino de Diagnóstico y Tratamiento, Ortopedia y Traumatología, Cirugía Artroscópica y Medicina del Deporte; Argentina
Fil: Belotti, Eduardo Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; Argentina
Fil: Ortega, Hugo Hector. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Ciencias Veterinarias del Litoral. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias. Instituto de Ciencias Veterinarias del Litoral; Argentina. Universidad Nacional del Litoral; Argentina
Fil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description We describe the functional capability of a cross-linked hydrogel composed of sulfated glycosaminoglycans and a cationic cellulose by conducting trials on experimental animal models using intra-articular implants to treat an articular disease called osteoarthritis. Forty-eight mature New Zealand white rabbits were divided into three experimental groups: A, B, and C. Group A and B underwent unilateral anterior cruciate ligament transection (ACLT) of the right knee. Subsequently, both knees of group A were treated with the injectable formulation under study. Meanwhile, group B was treated with sterile PBS (placebo). The animals of group C were surgically operated in both knees: Commercial hyaluronic acid (HA) was implanted in the left knee, and the formulation under study was implanted in the right knee. After implantation, all specimens underwent several evaluations at 3, 6, and 12 months postoperatively. At 6 months, no significant differences were detected between the right and left knees of the different groups. However, significant differences were observed between both knees at 12 months in group C, with less cartilage damage in the right knees implanted with our hydrogel. Therefore, in vivo studies have demonstrated hydrogel safety, superior permanence, and less cartilage damage for long-term follow up 12 months after implantation for the formulation under study compared with commercial HA.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157820
Bierbrauer, Karina Lilian; Alasino, Roxana Valeria; Barclay, Fernando E.; Belotti, Eduardo Matías; Ortega, Hugo Hector; et al.; Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model; MDPI; Polymers; 13; 24; 12-2021; 1-19
2073-4360
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157820
identifier_str_mv Bierbrauer, Karina Lilian; Alasino, Roxana Valeria; Barclay, Fernando E.; Belotti, Eduardo Matías; Ortega, Hugo Hector; et al.; Biocompatible hydrogel for intra-articular implantation comprising cationic and anionic polymers of natural origin: In vivo evaluation in a rabbit model; MDPI; Polymers; 13; 24; 12-2021; 1-19
2073-4360
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4360/13/24/4426
info:eu-repo/semantics/altIdentifier/doi/10.3390/polym13244426
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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