The role of Eudragit® as a component of hydrogel formulations for medical devices

Autores
Esporrín Ubieto, David; Sonzogni, Ana Sofía; Fernández, Mercedes; Acera, Arantxa; Matxinandiarena, Eider; Cadavid Vargas, Juan Fernando; Calafel, Itxaso; Schmarsow, Ruth Noemí; Müller, Alejandro J.; Larrañaga, Aitor; Calderón, Marcelo
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (e.g., mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery.
Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; España
Fil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Fernández, Mercedes. Universidad del Pais Vasco. Polymat.; España
Fil: Acera, Arantxa. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Fil: Matxinandiarena, Eider. Universidad del Pais Vasco. Polymat.; España
Fil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Calafel, Itxaso. Universidad del Pais Vasco. Polymat.; España
Fil: Schmarsow, Ruth Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Müller, Alejandro J.. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Fil: Larrañaga, Aitor. Universidad del Pais Vasco. Polymat.; España
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Materia
Eudragit
Hydrogel
Ocular delivery
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/225799
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The role of Eudragit® as a component of hydrogel formulations for medical devicesEsporrín Ubieto, DavidSonzogni, Ana SofíaFernández, MercedesAcera, ArantxaMatxinandiarena, EiderCadavid Vargas, Juan FernandoCalafel, ItxasoSchmarsow, Ruth NoemíMüller, Alejandro J.Larrañaga, AitorCalderón, MarceloEudragitHydrogelOcular deliveryhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (e.g., mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery.Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; EspañaFil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Fernández, Mercedes. Universidad del Pais Vasco. Polymat.; EspañaFil: Acera, Arantxa. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; EspañaFil: Matxinandiarena, Eider. Universidad del Pais Vasco. Polymat.; EspañaFil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Calafel, Itxaso. Universidad del Pais Vasco. Polymat.; EspañaFil: Schmarsow, Ruth Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Müller, Alejandro J.. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; EspañaFil: Larrañaga, Aitor. Universidad del Pais Vasco. Polymat.; EspañaFil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; EspañaRoyal Society of Chemistry2023-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/225799Esporrín Ubieto, David; Sonzogni, Ana Sofía; Fernández, Mercedes; Acera, Arantxa; Matxinandiarena, Eider; et al.; The role of Eudragit® as a component of hydrogel formulations for medical devices; Royal Society of Chemistry; Journal of Materials Chemistry B; 11; 38; 11-2023; 9276-92892050-750X2050-7518CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb01579cinfo:eu-repo/semantics/altIdentifier/doi/10.1039/D3TB01579Cinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:01Zoai:ri.conicet.gov.ar:11336/225799instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:01.926CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of Eudragit® as a component of hydrogel formulations for medical devices
title The role of Eudragit® as a component of hydrogel formulations for medical devices
spellingShingle The role of Eudragit® as a component of hydrogel formulations for medical devices
Esporrín Ubieto, David
Eudragit
Hydrogel
Ocular delivery
title_short The role of Eudragit® as a component of hydrogel formulations for medical devices
title_full The role of Eudragit® as a component of hydrogel formulations for medical devices
title_fullStr The role of Eudragit® as a component of hydrogel formulations for medical devices
title_full_unstemmed The role of Eudragit® as a component of hydrogel formulations for medical devices
title_sort The role of Eudragit® as a component of hydrogel formulations for medical devices
dc.creator.none.fl_str_mv Esporrín Ubieto, David
Sonzogni, Ana Sofía
Fernández, Mercedes
Acera, Arantxa
Matxinandiarena, Eider
Cadavid Vargas, Juan Fernando
Calafel, Itxaso
Schmarsow, Ruth Noemí
Müller, Alejandro J.
Larrañaga, Aitor
Calderón, Marcelo
author Esporrín Ubieto, David
author_facet Esporrín Ubieto, David
Sonzogni, Ana Sofía
Fernández, Mercedes
Acera, Arantxa
Matxinandiarena, Eider
Cadavid Vargas, Juan Fernando
Calafel, Itxaso
Schmarsow, Ruth Noemí
Müller, Alejandro J.
Larrañaga, Aitor
Calderón, Marcelo
author_role author
author2 Sonzogni, Ana Sofía
Fernández, Mercedes
Acera, Arantxa
Matxinandiarena, Eider
Cadavid Vargas, Juan Fernando
Calafel, Itxaso
Schmarsow, Ruth Noemí
Müller, Alejandro J.
Larrañaga, Aitor
Calderón, Marcelo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Eudragit
Hydrogel
Ocular delivery
topic Eudragit
Hydrogel
Ocular delivery
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (e.g., mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery.
Fil: Esporrín Ubieto, David. Universidad del Pais Vasco. Polymat.; España
Fil: Sonzogni, Ana Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Fernández, Mercedes. Universidad del Pais Vasco. Polymat.; España
Fil: Acera, Arantxa. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Fil: Matxinandiarena, Eider. Universidad del Pais Vasco. Polymat.; España
Fil: Cadavid Vargas, Juan Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Calafel, Itxaso. Universidad del Pais Vasco. Polymat.; España
Fil: Schmarsow, Ruth Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Müller, Alejandro J.. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
Fil: Larrañaga, Aitor. Universidad del Pais Vasco. Polymat.; España
Fil: Calderón, Marcelo. Universidad del Pais Vasco. Polymat.; España. IKERBASQUE; España
description Over the last decade, significant progress has been made in developing hydrogels as medical devices. By physically cross-linking pharmaceutically approved polymers into three-dimensional matrices, we can ensure their biocompatibility and facilitate their seamless transition from the laboratory to clinical applications. Moreover, the reversible nature of their physical cross-links allows hydrogels to dissolve in the presence of external stimuli. Particularly, their high degree of hydration, high molecular weight, and superior flexibility of the polymer chains facilitate their interaction with complex biological barriers (e.g., mucus layer), making them ideal candidates for mucosal drug delivery. However, fine-tuning the composition of the hydrogel formulations is of great importance to optimize the performance of the medical device and its therapeutic cargo. Herein, we investigated the influence of different Eudragits® on the properties of hydrogels based on polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), and polyethylene glycol (PEG), which were originally proposed as ocular inserts in previous reports. Our research aims to determine the effects that including different Eudragits® have on the structure and protein ocular delivery ability of various hydrogel formulations. Properties such as matrix stability, protein encapsulation, release kinetics, mucoadhesion, and biocompatibility have been analyzed in detail. Our study represents a guideline of the features that Eudragits® have to exhibit to endow hydrogels with good adhesion to the eye's conjunctiva, biocompatibility, and structural strength to cope with the ocular biointerface and allow sustained protein release. This work has important implications for the design of new hydrogel materials containing Eudragits® in their composition, particularly in mucosal drug delivery.
publishDate 2023
dc.date.none.fl_str_mv 2023-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/225799
Esporrín Ubieto, David; Sonzogni, Ana Sofía; Fernández, Mercedes; Acera, Arantxa; Matxinandiarena, Eider; et al.; The role of Eudragit® as a component of hydrogel formulations for medical devices; Royal Society of Chemistry; Journal of Materials Chemistry B; 11; 38; 11-2023; 9276-9289
2050-750X
2050-7518
CONICET Digital
CONICET
url http://hdl.handle.net/11336/225799
identifier_str_mv Esporrín Ubieto, David; Sonzogni, Ana Sofía; Fernández, Mercedes; Acera, Arantxa; Matxinandiarena, Eider; et al.; The role of Eudragit® as a component of hydrogel formulations for medical devices; Royal Society of Chemistry; Journal of Materials Chemistry B; 11; 38; 11-2023; 9276-9289
2050-750X
2050-7518
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb01579c
info:eu-repo/semantics/altIdentifier/doi/10.1039/D3TB01579C
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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