High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study

Autores
Martín Giménez, Virna Margarita; Mariani, Javier; Antonietti, Laura; Tajer, Carlos Daniel; Inserra, Felipe; Ferder, Leon Fernando; Gonzalez Maglio, Daniel Horacio; Gironacci, Mariela Mercedes; Manucha, Walter Ariel Fernando
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Previously, we evaluated angiotensin levels and the cytokine profile in patients with mild COVID-19 and treated with high doses of vitamin D3 (ClinicalTrials.gov NCT04411446). Unfortunately, this treatment did not improve the protective components.Objectives: To perform a sub-study excluding old and obese patients as possible confounders. Methods: From the initial 16 patients, we excluded those with BMI greater than 40 and those older than 70 and were randomized to a single oral dose of 500,000 IU vitamin D3 (n=7) or placebo (n=4). Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and TNF-α by ELISA before and after treatment. Parallel, serum 25-OH vitamin D concentrations was measured by a chemiluminescence immunoassay.Results: We verified a trend to the highest reduction in pro-inflammatory ILs and protective markers of Ang-(1-7) and Ang-(1-7)/Ang II ratio in the vitamin D3 treated group.Conclusions: High-dose vitamin D3 supplementation in mild to moderate COVID-19-positive patients with plasma vitamin D levels within the normal range -even eliminating obesity and ageing- did not cause significant changes in clinical aspects.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
COVID-19
VITAMIN D
ANGIOTENSINS
INTERLEUKINS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/233315
Acceder
id CONICETDig_9bc934f86172e948283ad09e4c938267
oai_identifier_str oai:ri.conicet.gov.ar:11336/233315
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical studyMartín Giménez, Virna MargaritaMariani, JavierAntonietti, LauraTajer, Carlos DanielInserra, FelipeFerder, Leon FernandoGonzalez Maglio, Daniel HoracioGironacci, Mariela MercedesManucha, Walter Ariel FernandoCOVID-19VITAMIN DANGIOTENSINSINTERLEUKINShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Previously, we evaluated angiotensin levels and the cytokine profile in patients with mild COVID-19 and treated with high doses of vitamin D3 (ClinicalTrials.gov NCT04411446). Unfortunately, this treatment did not improve the protective components.Objectives: To perform a sub-study excluding old and obese patients as possible confounders. Methods: From the initial 16 patients, we excluded those with BMI greater than 40 and those older than 70 and were randomized to a single oral dose of 500,000 IU vitamin D3 (n=7) or placebo (n=4). Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and TNF-α by ELISA before and after treatment. Parallel, serum 25-OH vitamin D concentrations was measured by a chemiluminescence immunoassay.Results: We verified a trend to the highest reduction in pro-inflammatory ILs and protective markers of Ang-(1-7) and Ang-(1-7)/Ang II ratio in the vitamin D3 treated group.Conclusions: High-dose vitamin D3 supplementation in mild to moderate COVID-19-positive patients with plasma vitamin D levels within the normal range -even eliminating obesity and ageing- did not cause significant changes in clinical aspects.Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Inserra, Felipe. Universidad Maimónides; ArgentinaFil: Ferder, Leon Fernando. Universidad Maimónides; ArgentinaFil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaIris Publishers2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/233315Martín Giménez, Virna Margarita; Mariani, Javier; Antonietti, Laura; Tajer, Carlos Daniel; Inserra, Felipe; et al.; High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study; Iris Publishers; Archives of Pharmacy & Pharmacology Research; 3; 4; 5-2023; 1-32641-2020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://irispublishers.com/appr/fulltext/High-Doses-of-Vitamin-D3-In-a-Sub-Group-of-Covid-19-Patients-Who-Participated-in-Cared-Clinical-Study.ID.000569.phpinfo:eu-repo/semantics/altIdentifier/doi/10.33552/APPR.2023.03.000569info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:48Zoai:ri.conicet.gov.ar:11336/233315instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:49.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
title High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
spellingShingle High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
Martín Giménez, Virna Margarita
COVID-19
VITAMIN D
ANGIOTENSINS
INTERLEUKINS
title_short High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
title_full High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
title_fullStr High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
title_full_unstemmed High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
title_sort High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
Mariani, Javier
Antonietti, Laura
Tajer, Carlos Daniel
Inserra, Felipe
Ferder, Leon Fernando
Gonzalez Maglio, Daniel Horacio
Gironacci, Mariela Mercedes
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
Mariani, Javier
Antonietti, Laura
Tajer, Carlos Daniel
Inserra, Felipe
Ferder, Leon Fernando
Gonzalez Maglio, Daniel Horacio
Gironacci, Mariela Mercedes
Manucha, Walter Ariel Fernando
author_role author
author2 Mariani, Javier
Antonietti, Laura
Tajer, Carlos Daniel
Inserra, Felipe
Ferder, Leon Fernando
Gonzalez Maglio, Daniel Horacio
Gironacci, Mariela Mercedes
Manucha, Walter Ariel Fernando
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
VITAMIN D
ANGIOTENSINS
INTERLEUKINS
topic COVID-19
VITAMIN D
ANGIOTENSINS
INTERLEUKINS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Previously, we evaluated angiotensin levels and the cytokine profile in patients with mild COVID-19 and treated with high doses of vitamin D3 (ClinicalTrials.gov NCT04411446). Unfortunately, this treatment did not improve the protective components.Objectives: To perform a sub-study excluding old and obese patients as possible confounders. Methods: From the initial 16 patients, we excluded those with BMI greater than 40 and those older than 70 and were randomized to a single oral dose of 500,000 IU vitamin D3 (n=7) or placebo (n=4). Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and TNF-α by ELISA before and after treatment. Parallel, serum 25-OH vitamin D concentrations was measured by a chemiluminescence immunoassay.Results: We verified a trend to the highest reduction in pro-inflammatory ILs and protective markers of Ang-(1-7) and Ang-(1-7)/Ang II ratio in the vitamin D3 treated group.Conclusions: High-dose vitamin D3 supplementation in mild to moderate COVID-19-positive patients with plasma vitamin D levels within the normal range -even eliminating obesity and ageing- did not cause significant changes in clinical aspects.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: Mariani, Javier. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Antonietti, Laura. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Tajer, Carlos Daniel. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Inserra, Felipe. Universidad Maimónides; Argentina
Fil: Ferder, Leon Fernando. Universidad Maimónides; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description Background: Previously, we evaluated angiotensin levels and the cytokine profile in patients with mild COVID-19 and treated with high doses of vitamin D3 (ClinicalTrials.gov NCT04411446). Unfortunately, this treatment did not improve the protective components.Objectives: To perform a sub-study excluding old and obese patients as possible confounders. Methods: From the initial 16 patients, we excluded those with BMI greater than 40 and those older than 70 and were randomized to a single oral dose of 500,000 IU vitamin D3 (n=7) or placebo (n=4). Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and TNF-α by ELISA before and after treatment. Parallel, serum 25-OH vitamin D concentrations was measured by a chemiluminescence immunoassay.Results: We verified a trend to the highest reduction in pro-inflammatory ILs and protective markers of Ang-(1-7) and Ang-(1-7)/Ang II ratio in the vitamin D3 treated group.Conclusions: High-dose vitamin D3 supplementation in mild to moderate COVID-19-positive patients with plasma vitamin D levels within the normal range -even eliminating obesity and ageing- did not cause significant changes in clinical aspects.
publishDate 2023
dc.date.none.fl_str_mv 2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/233315
Martín Giménez, Virna Margarita; Mariani, Javier; Antonietti, Laura; Tajer, Carlos Daniel; Inserra, Felipe; et al.; High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study; Iris Publishers; Archives of Pharmacy & Pharmacology Research; 3; 4; 5-2023; 1-3
2641-2020
CONICET Digital
CONICET
url http://hdl.handle.net/11336/233315
identifier_str_mv Martín Giménez, Virna Margarita; Mariani, Javier; Antonietti, Laura; Tajer, Carlos Daniel; Inserra, Felipe; et al.; High doses of vitamin D3 in a sub-group of COVID-19 patients who participated in CARED clinical study; Iris Publishers; Archives of Pharmacy & Pharmacology Research; 3; 4; 5-2023; 1-3
2641-2020
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://irispublishers.com/appr/fulltext/High-Doses-of-Vitamin-D3-In-a-Sub-Group-of-Covid-19-Patients-Who-Participated-in-Cared-Clinical-Study.ID.000569.php
info:eu-repo/semantics/altIdentifier/doi/10.33552/APPR.2023.03.000569
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Iris Publishers
publisher.none.fl_str_mv Iris Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269719885774848
score 13.13397

Publicaciones similares