Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level

Autores
Martín Giménez, Virna Margarita; García Menéndez, Sebastián Marcelo Manuel; Holick, Michael F.; Manucha, Walter Ariel Fernando
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Drug discovery and development are usually very costly and time-consuming. Therefore, drug repurposing is an attractive option for treating multiple diseases due to significantly reducing the time and costs invested in these tasks while using less risky compounds. Moreover, drug repurposing may help to discover new drug targets and signaling pathways that may be therapeutically exploited. Such is the case of vitamin D (or hormone D), which has recently gained relevance in clinical and experimental medicine with an impact on pathologies other than the phosphocalcic mechanism. In this sense, there is accumulated evidence that supports that -from now on- vitamin D (or more recently called hormone D) should be recognized both for its vascular anti-inflammatory actions as well as its bone effects. Likewise, this compound could be proposed as a new therapeutic alternative in the prevention and treatment of hypertension, atherosclerosis, and many other vascular inflammatory diseases due to the possibility of being used as a repurposed drug.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: García Menéndez, Sebastián Marcelo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Holick, Michael F.. University Of Boston. School Of Medicine.; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Materia
VITAMIN D
REPURPOSED DRUG
ANTI-IMFLAMMATORY DRUG
CARDIOVASCULAR DISEASES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248598
Acceder
id CONICETDig_2f599b4ef688d671b609606f3e325d0c
oai_identifier_str oai:ri.conicet.gov.ar:11336/248598
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular LevelMartín Giménez, Virna MargaritaGarcía Menéndez, Sebastián Marcelo ManuelHolick, Michael F.Manucha, Walter Ariel FernandoVITAMIN DREPURPOSED DRUGANTI-IMFLAMMATORY DRUGCARDIOVASCULAR DISEASEShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Drug discovery and development are usually very costly and time-consuming. Therefore, drug repurposing is an attractive option for treating multiple diseases due to significantly reducing the time and costs invested in these tasks while using less risky compounds. Moreover, drug repurposing may help to discover new drug targets and signaling pathways that may be therapeutically exploited. Such is the case of vitamin D (or hormone D), which has recently gained relevance in clinical and experimental medicine with an impact on pathologies other than the phosphocalcic mechanism. In this sense, there is accumulated evidence that supports that -from now on- vitamin D (or more recently called hormone D) should be recognized both for its vascular anti-inflammatory actions as well as its bone effects. Likewise, this compound could be proposed as a new therapeutic alternative in the prevention and treatment of hypertension, atherosclerosis, and many other vascular inflammatory diseases due to the possibility of being used as a repurposed drug.Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; ArgentinaFil: García Menéndez, Sebastián Marcelo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Holick, Michael F.. University Of Boston. School Of Medicine.; Estados UnidosFil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaBentham Science Publishers2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248598Martín Giménez, Virna Margarita; García Menéndez, Sebastián Marcelo Manuel; Holick, Michael F.; Manucha, Walter Ariel Fernando; Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level; Bentham Science Publishers; Current Protein and Peptide Science; 24; 7; 6-2023; 533-5351389-20371875-5550CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/article/132637info:eu-repo/semantics/altIdentifier/doi/10.2174/1389203724666230622162539info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:54Zoai:ri.conicet.gov.ar:11336/248598instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:54.435CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
title Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
spellingShingle Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
Martín Giménez, Virna Margarita
VITAMIN D
REPURPOSED DRUG
ANTI-IMFLAMMATORY DRUG
CARDIOVASCULAR DISEASES
title_short Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
title_full Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
title_fullStr Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
title_full_unstemmed Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
title_sort Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level
dc.creator.none.fl_str_mv Martín Giménez, Virna Margarita
García Menéndez, Sebastián Marcelo Manuel
Holick, Michael F.
Manucha, Walter Ariel Fernando
author Martín Giménez, Virna Margarita
author_facet Martín Giménez, Virna Margarita
García Menéndez, Sebastián Marcelo Manuel
Holick, Michael F.
Manucha, Walter Ariel Fernando
author_role author
author2 García Menéndez, Sebastián Marcelo Manuel
Holick, Michael F.
Manucha, Walter Ariel Fernando
author2_role author
author
author
dc.subject.none.fl_str_mv VITAMIN D
REPURPOSED DRUG
ANTI-IMFLAMMATORY DRUG
CARDIOVASCULAR DISEASES
topic VITAMIN D
REPURPOSED DRUG
ANTI-IMFLAMMATORY DRUG
CARDIOVASCULAR DISEASES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Drug discovery and development are usually very costly and time-consuming. Therefore, drug repurposing is an attractive option for treating multiple diseases due to significantly reducing the time and costs invested in these tasks while using less risky compounds. Moreover, drug repurposing may help to discover new drug targets and signaling pathways that may be therapeutically exploited. Such is the case of vitamin D (or hormone D), which has recently gained relevance in clinical and experimental medicine with an impact on pathologies other than the phosphocalcic mechanism. In this sense, there is accumulated evidence that supports that -from now on- vitamin D (or more recently called hormone D) should be recognized both for its vascular anti-inflammatory actions as well as its bone effects. Likewise, this compound could be proposed as a new therapeutic alternative in the prevention and treatment of hypertension, atherosclerosis, and many other vascular inflammatory diseases due to the possibility of being used as a repurposed drug.
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Catolica de Cuyo - Sede San Juan. Facultad de Ciencias de la Alimentación, Bioquímicas y Farmacéuticas. Instituto de Investigación en Ciencias Químicas; Argentina
Fil: García Menéndez, Sebastián Marcelo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Holick, Michael F.. University Of Boston. School Of Medicine.; Estados Unidos
Fil: Manucha, Walter Ariel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
description Drug discovery and development are usually very costly and time-consuming. Therefore, drug repurposing is an attractive option for treating multiple diseases due to significantly reducing the time and costs invested in these tasks while using less risky compounds. Moreover, drug repurposing may help to discover new drug targets and signaling pathways that may be therapeutically exploited. Such is the case of vitamin D (or hormone D), which has recently gained relevance in clinical and experimental medicine with an impact on pathologies other than the phosphocalcic mechanism. In this sense, there is accumulated evidence that supports that -from now on- vitamin D (or more recently called hormone D) should be recognized both for its vascular anti-inflammatory actions as well as its bone effects. Likewise, this compound could be proposed as a new therapeutic alternative in the prevention and treatment of hypertension, atherosclerosis, and many other vascular inflammatory diseases due to the possibility of being used as a repurposed drug.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248598
Martín Giménez, Virna Margarita; García Menéndez, Sebastián Marcelo Manuel; Holick, Michael F.; Manucha, Walter Ariel Fernando; Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level; Bentham Science Publishers; Current Protein and Peptide Science; 24; 7; 6-2023; 533-535
1389-2037
1875-5550
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248598
identifier_str_mv Martín Giménez, Virna Margarita; García Menéndez, Sebastián Marcelo Manuel; Holick, Michael F.; Manucha, Walter Ariel Fernando; Vitamin D: A Repurposed Anti-inflammatory Drug at the Cardiovascular Level; Bentham Science Publishers; Current Protein and Peptide Science; 24; 7; 6-2023; 533-535
1389-2037
1875-5550
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/article/132637
info:eu-repo/semantics/altIdentifier/doi/10.2174/1389203724666230622162539
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268696398004224
score 13.13397

Publicaciones similares