Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging

Autores
Nador, Fabiana Gabriela; Wnuk, Karolina; García-Pardo, Javier; Lorenzo, Julia; Solorzano, Rubén; Ruiz Molina, Daniel; Novio, Fernando
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional fluorescent nanostructures have been developed. The first strategy was based on the synthesis of the coordination polymers structured as nanoparticles by coordination of CoII ions to two different catechol ligands containing free functional chemical groups (dopamine and 3,4-dihydroxybenzaldehyde), and a bis(imidazole)-based ligand (1,4-bis(imidazole-1-ylmethyl)benzene, bix). Subsequently, different dyes, namely fluorescein isothiocyanate (FITC), 1-pyrenebutanoic acid hydrazide (PBH) or Alexa Fluor® 568 (A568), could be sequentially attached to the surface of the nanoparticles. The second strategy was focused on the prefunctionalization of catechol ligands with the corresponding dyes and, afterwards, the coordination with the metal ions in presence of bix. In vitro studies demonstrated the internalization of the bifunctional nanoparticles and the persistence of the fluorescent properties after cell uptake without dye leaching.
Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Wnuk, Karolina. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: García-Pardo, Javier. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Lorenzo, Julia. Universitat Autònoma de Barcelona; España
Fil: Solorzano, Rubén. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Ruiz Molina, Daniel. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Novio, Fernando. Universitat Autònoma de Barcelona; España. Consejo Superior de Investigaciones Científicas; España. Barcelona Institute of Science and Technology; España
Materia
BIOSENSORS
CATECHOL
COORDINATION POLYMERS
FLUORESCENT PROBES
NANOPARTICLES
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/56829
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel ImagingNador, Fabiana GabrielaWnuk, KarolinaGarcía-Pardo, JavierLorenzo, JuliaSolorzano, RubénRuiz Molina, DanielNovio, FernandoBIOSENSORSCATECHOLCOORDINATION POLYMERSFLUORESCENT PROBESNANOPARTICLEShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional fluorescent nanostructures have been developed. The first strategy was based on the synthesis of the coordination polymers structured as nanoparticles by coordination of CoII ions to two different catechol ligands containing free functional chemical groups (dopamine and 3,4-dihydroxybenzaldehyde), and a bis(imidazole)-based ligand (1,4-bis(imidazole-1-ylmethyl)benzene, bix). Subsequently, different dyes, namely fluorescein isothiocyanate (FITC), 1-pyrenebutanoic acid hydrazide (PBH) or Alexa Fluor® 568 (A568), could be sequentially attached to the surface of the nanoparticles. The second strategy was focused on the prefunctionalization of catechol ligands with the corresponding dyes and, afterwards, the coordination with the metal ions in presence of bix. In vitro studies demonstrated the internalization of the bifunctional nanoparticles and the persistence of the fluorescent properties after cell uptake without dye leaching.Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; EspañaFil: Wnuk, Karolina. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; EspañaFil: García-Pardo, Javier. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; EspañaFil: Lorenzo, Julia. Universitat Autònoma de Barcelona; EspañaFil: Solorzano, Rubén. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; EspañaFil: Ruiz Molina, Daniel. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; EspañaFil: Novio, Fernando. Universitat Autònoma de Barcelona; España. Consejo Superior de Investigaciones Científicas; España. Barcelona Institute of Science and Technology; EspañaWiley-VCH2018-02-06info:eu-repo/date/embargoEnd/2019-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/56829Nador, Fabiana Gabriela; Wnuk, Karolina; García-Pardo, Javier; Lorenzo, Julia; Solorzano, Rubén; et al.; Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging; Wiley-VCH; ChemNanoMat; 4; 2; 6-2-2018; 183-1932199-692XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/cnma.201700311info:eu-repo/semantics/altIdentifier/doi/10.1002/cnma.201700311info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:26Zoai:ri.conicet.gov.ar:11336/56829instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:26.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
title Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
spellingShingle Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
Nador, Fabiana Gabriela
BIOSENSORS
CATECHOL
COORDINATION POLYMERS
FLUORESCENT PROBES
NANOPARTICLES
title_short Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
title_full Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
title_fullStr Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
title_full_unstemmed Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
title_sort Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging
dc.creator.none.fl_str_mv Nador, Fabiana Gabriela
Wnuk, Karolina
García-Pardo, Javier
Lorenzo, Julia
Solorzano, Rubén
Ruiz Molina, Daniel
Novio, Fernando
author Nador, Fabiana Gabriela
author_facet Nador, Fabiana Gabriela
Wnuk, Karolina
García-Pardo, Javier
Lorenzo, Julia
Solorzano, Rubén
Ruiz Molina, Daniel
Novio, Fernando
author_role author
author2 Wnuk, Karolina
García-Pardo, Javier
Lorenzo, Julia
Solorzano, Rubén
Ruiz Molina, Daniel
Novio, Fernando
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOSENSORS
CATECHOL
COORDINATION POLYMERS
FLUORESCENT PROBES
NANOPARTICLES
topic BIOSENSORS
CATECHOL
COORDINATION POLYMERS
FLUORESCENT PROBES
NANOPARTICLES
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional fluorescent nanostructures have been developed. The first strategy was based on the synthesis of the coordination polymers structured as nanoparticles by coordination of CoII ions to two different catechol ligands containing free functional chemical groups (dopamine and 3,4-dihydroxybenzaldehyde), and a bis(imidazole)-based ligand (1,4-bis(imidazole-1-ylmethyl)benzene, bix). Subsequently, different dyes, namely fluorescein isothiocyanate (FITC), 1-pyrenebutanoic acid hydrazide (PBH) or Alexa Fluor® 568 (A568), could be sequentially attached to the surface of the nanoparticles. The second strategy was focused on the prefunctionalization of catechol ligands with the corresponding dyes and, afterwards, the coordination with the metal ions in presence of bix. In vitro studies demonstrated the internalization of the bifunctional nanoparticles and the persistence of the fluorescent properties after cell uptake without dye leaching.
Fil: Nador, Fabiana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Wnuk, Karolina. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: García-Pardo, Javier. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Lorenzo, Julia. Universitat Autònoma de Barcelona; España
Fil: Solorzano, Rubén. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Ruiz Molina, Daniel. Barcelona Institute of Science and Technology; España. Consejo Superior de Investigaciones Científicas; España. Universitat Autònoma de Barcelona; España
Fil: Novio, Fernando. Universitat Autònoma de Barcelona; España. Consejo Superior de Investigaciones Científicas; España. Barcelona Institute of Science and Technology; España
description Two rationally designed strategies for covalent bonding of fluorescent dyes in coordination polymer nanoparticles aiming to achieve bifunctional fluorescent nanostructures have been developed. The first strategy was based on the synthesis of the coordination polymers structured as nanoparticles by coordination of CoII ions to two different catechol ligands containing free functional chemical groups (dopamine and 3,4-dihydroxybenzaldehyde), and a bis(imidazole)-based ligand (1,4-bis(imidazole-1-ylmethyl)benzene, bix). Subsequently, different dyes, namely fluorescein isothiocyanate (FITC), 1-pyrenebutanoic acid hydrazide (PBH) or Alexa Fluor® 568 (A568), could be sequentially attached to the surface of the nanoparticles. The second strategy was focused on the prefunctionalization of catechol ligands with the corresponding dyes and, afterwards, the coordination with the metal ions in presence of bix. In vitro studies demonstrated the internalization of the bifunctional nanoparticles and the persistence of the fluorescent properties after cell uptake without dye leaching.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-06
info:eu-repo/date/embargoEnd/2019-03-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/56829
Nador, Fabiana Gabriela; Wnuk, Karolina; García-Pardo, Javier; Lorenzo, Julia; Solorzano, Rubén; et al.; Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging; Wiley-VCH; ChemNanoMat; 4; 2; 6-2-2018; 183-193
2199-692X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/56829
identifier_str_mv Nador, Fabiana Gabriela; Wnuk, Karolina; García-Pardo, Javier; Lorenzo, Julia; Solorzano, Rubén; et al.; Dual-Fluorescent Nanoscale Coordination Polymers via a Mixed-Ligand Synthetic Strategy and Their Use for Multichannel Imaging; Wiley-VCH; ChemNanoMat; 4; 2; 6-2-2018; 183-193
2199-692X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/cnma.201700311
info:eu-repo/semantics/altIdentifier/doi/10.1002/cnma.201700311
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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