Short hydrogen bonds enhance nonaromatic protein-related fluorescence

Autores: Stephens, Amberley D.; Qaisrani, Muhammad Nawaz; Ruggiero, Michael T.; Díaz Mirón, Gonzalo; Morzan, Uriel; González Lebrero, Mariano Camilo; Jones, Saul T. E.; Poli, Emiliano; Bond, Andrew D.; Woodhams, Philippa J.; Kleist, Elyse M.; Grisanti, Luca; Gebauer, Ralph; Zeitler, J. Axel; Abadie, Nicolás Daniel; Hassanali, Ali; Kaminski Schierle, Gabriele S.
Año de publicación: 2021
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational approach, we show that specific hydrogen bond networks can significantly affect fluorescence. In particular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation leading to the formation of a short hydrogen bond, displays optical properties that are significantly enhanced compared with L-glutamine itself. Ab initio molecular dynamics simulations highlight that these short hydrogen bonds prevent the appearance of a conical intersection between the excited and the ground states and thereby significantly decrease nonradiative transition probabilities. Our findings open the door to the design of new photoactive materials with biophotonic applications.
Fil: Stephens, Amberley D.. University of Cambridge; Reino Unido
Fil: Qaisrani, Muhammad Nawaz. The Abdus Salam; Italia. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Ruggiero, Michael T.. University of Cambridge; Reino Unido. University of Vermont; Estados Unidos
Fil: Díaz Mirón, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Morzan, Uriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: González Lebrero, Mariano Camilo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jones, Saul T. E.. University of Cambridge; Reino Unido
Fil: Poli, Emiliano. The Abdus Salam; Italia
Fil: Bond, Andrew D.. University of Cambridge; Reino Unido
Fil: Woodhams, Philippa J.. University of Cambridge; Reino Unido
Fil: Kleist, Elyse M.. University of Vermont; Estados Unidos
Fil: Grisanti, Luca. Ruđer Boškovic Institute; Croacia
Fil: Gebauer, Ralph. The Abdus Salam; Italia
Fil: Zeitler, J. Axel. University of Cambridge; Reino Unido
Fil: Abadie, Nicolás Daniel. University of Cambridge; Reino Unido
Fil: Hassanali, Ali. The Abdus Salam; Italia
Fil: Kaminski Schierle, Gabriele S.. University of Cambridge; Reino Unido
Materia: INTRINSIC FLUORESCENCE
SHORT HYDROGEN BOND
ULTRAVIOLET FLUORESCENCE
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/182072

Acceder

id	CONICETDig_9afa1ecda84a24eb48f670fda57f3ea1
oai_identifier_str	oai:ri.conicet.gov.ar:11336/182072
network_acronym_str	CONICETDig
repository_id_str	3498
network_name_str	CONICET Digital (CONICET)
spelling	Short hydrogen bonds enhance nonaromatic protein-related fluorescenceStephens, Amberley D.Qaisrani, Muhammad NawazRuggiero, Michael T.Díaz Mirón, GonzaloMorzan, UrielGonzález Lebrero, Mariano CamiloJones, Saul T. E.Poli, EmilianoBond, Andrew D.Woodhams, Philippa J.Kleist, Elyse M.Grisanti, LucaGebauer, RalphZeitler, J. AxelAbadie, Nicolás DanielHassanali, AliKaminski Schierle, Gabriele S.INTRINSIC FLUORESCENCESHORT HYDROGEN BONDULTRAVIOLET FLUORESCENCEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational approach, we show that specific hydrogen bond networks can significantly affect fluorescence. In particular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation leading to the formation of a short hydrogen bond, displays optical properties that are significantly enhanced compared with L-glutamine itself. Ab initio molecular dynamics simulations highlight that these short hydrogen bonds prevent the appearance of a conical intersection between the excited and the ground states and thereby significantly decrease nonradiative transition probabilities. Our findings open the door to the design of new photoactive materials with biophotonic applications.Fil: Stephens, Amberley D.. University of Cambridge; Reino UnidoFil: Qaisrani, Muhammad Nawaz. The Abdus Salam; Italia. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Ruggiero, Michael T.. University of Cambridge; Reino Unido. University of Vermont; Estados UnidosFil: Díaz Mirón, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Morzan, Uriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: González Lebrero, Mariano Camilo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jones, Saul T. E.. University of Cambridge; Reino UnidoFil: Poli, Emiliano. The Abdus Salam; ItaliaFil: Bond, Andrew D.. University of Cambridge; Reino UnidoFil: Woodhams, Philippa J.. University of Cambridge; Reino UnidoFil: Kleist, Elyse M.. University of Vermont; Estados UnidosFil: Grisanti, Luca. Ruđer Boškovic Institute; CroaciaFil: Gebauer, Ralph. The Abdus Salam; ItaliaFil: Zeitler, J. Axel. University of Cambridge; Reino UnidoFil: Abadie, Nicolás Daniel. University of Cambridge; Reino UnidoFil: Hassanali, Ali. The Abdus Salam; ItaliaFil: Kaminski Schierle, Gabriele S.. University of Cambridge; Reino UnidoNational Academy of Sciences2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/182072Stephens, Amberley D.; Qaisrani, Muhammad Nawaz; Ruggiero, Michael T.; Díaz Mirón, Gonzalo; Morzan, Uriel; et al.; Short hydrogen bonds enhance nonaromatic protein-related fluorescence; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 21; 5-20210027-8424CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/lookup/doi/10.1073/pnas.2020389118info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2020389118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:01Zoai:ri.conicet.gov.ar:11336/182072instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:01.488CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
title	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
spellingShingle	Short hydrogen bonds enhance nonaromatic protein-related fluorescence Stephens, Amberley D. INTRINSIC FLUORESCENCE SHORT HYDROGEN BOND ULTRAVIOLET FLUORESCENCE
title_short	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
title_full	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
title_fullStr	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
title_full_unstemmed	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
title_sort	Short hydrogen bonds enhance nonaromatic protein-related fluorescence
dc.creator.none.fl_str_mv	Stephens, Amberley D. Qaisrani, Muhammad Nawaz Ruggiero, Michael T. Díaz Mirón, Gonzalo Morzan, Uriel González Lebrero, Mariano Camilo Jones, Saul T. E. Poli, Emiliano Bond, Andrew D. Woodhams, Philippa J. Kleist, Elyse M. Grisanti, Luca Gebauer, Ralph Zeitler, J. Axel Abadie, Nicolás Daniel Hassanali, Ali Kaminski Schierle, Gabriele S.
author	Stephens, Amberley D.
author_facet	Stephens, Amberley D. Qaisrani, Muhammad Nawaz Ruggiero, Michael T. Díaz Mirón, Gonzalo Morzan, Uriel González Lebrero, Mariano Camilo Jones, Saul T. E. Poli, Emiliano Bond, Andrew D. Woodhams, Philippa J. Kleist, Elyse M. Grisanti, Luca Gebauer, Ralph Zeitler, J. Axel Abadie, Nicolás Daniel Hassanali, Ali Kaminski Schierle, Gabriele S.
author_role	author
author2	Qaisrani, Muhammad Nawaz Ruggiero, Michael T. Díaz Mirón, Gonzalo Morzan, Uriel González Lebrero, Mariano Camilo Jones, Saul T. E. Poli, Emiliano Bond, Andrew D. Woodhams, Philippa J. Kleist, Elyse M. Grisanti, Luca Gebauer, Ralph Zeitler, J. Axel Abadie, Nicolás Daniel Hassanali, Ali Kaminski Schierle, Gabriele S.
author2_role	author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	INTRINSIC FLUORESCENCE SHORT HYDROGEN BOND ULTRAVIOLET FLUORESCENCE
topic	INTRINSIC FLUORESCENCE SHORT HYDROGEN BOND ULTRAVIOLET FLUORESCENCE
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational approach, we show that specific hydrogen bond networks can significantly affect fluorescence. In particular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation leading to the formation of a short hydrogen bond, displays optical properties that are significantly enhanced compared with L-glutamine itself. Ab initio molecular dynamics simulations highlight that these short hydrogen bonds prevent the appearance of a conical intersection between the excited and the ground states and thereby significantly decrease nonradiative transition probabilities. Our findings open the door to the design of new photoactive materials with biophotonic applications. Fil: Stephens, Amberley D.. University of Cambridge; Reino Unido Fil: Qaisrani, Muhammad Nawaz. The Abdus Salam; Italia. Johannes Gutenberg Universitat Mainz; Alemania Fil: Ruggiero, Michael T.. University of Cambridge; Reino Unido. University of Vermont; Estados Unidos Fil: Díaz Mirón, Gonzalo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: Morzan, Uriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina Fil: González Lebrero, Mariano Camilo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Inorgánica, Analítica y Química Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Jones, Saul T. E.. University of Cambridge; Reino Unido Fil: Poli, Emiliano. The Abdus Salam; Italia Fil: Bond, Andrew D.. University of Cambridge; Reino Unido Fil: Woodhams, Philippa J.. University of Cambridge; Reino Unido Fil: Kleist, Elyse M.. University of Vermont; Estados Unidos Fil: Grisanti, Luca. Ruđer Boškovic Institute; Croacia Fil: Gebauer, Ralph. The Abdus Salam; Italia Fil: Zeitler, J. Axel. University of Cambridge; Reino Unido Fil: Abadie, Nicolás Daniel. University of Cambridge; Reino Unido Fil: Hassanali, Ali. The Abdus Salam; Italia Fil: Kaminski Schierle, Gabriele S.. University of Cambridge; Reino Unido
description	Fluorescence in biological systems is usually associated with the presence of aromatic groups. Here, by employing a combined experimental and computational approach, we show that specific hydrogen bond networks can significantly affect fluorescence. In particular, we reveal that the single amino acid L-glutamine, by undergoing a chemical transformation leading to the formation of a short hydrogen bond, displays optical properties that are significantly enhanced compared with L-glutamine itself. Ab initio molecular dynamics simulations highlight that these short hydrogen bonds prevent the appearance of a conical intersection between the excited and the ground states and thereby significantly decrease nonradiative transition probabilities. Our findings open the door to the design of new photoactive materials with biophotonic applications.
publishDate	2021
dc.date.none.fl_str_mv	2021-05
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/182072 Stephens, Amberley D.; Qaisrani, Muhammad Nawaz; Ruggiero, Michael T.; Díaz Mirón, Gonzalo; Morzan, Uriel; et al.; Short hydrogen bonds enhance nonaromatic protein-related fluorescence; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 21; 5-2021 0027-8424 CONICET Digital CONICET
url	http://hdl.handle.net/11336/182072
identifier_str_mv	Stephens, Amberley D.; Qaisrani, Muhammad Nawaz; Ruggiero, Michael T.; Díaz Mirón, Gonzalo; Morzan, Uriel; et al.; Short hydrogen bonds enhance nonaromatic protein-related fluorescence; National Academy of Sciences; Proceedings of the National Academy of Sciences of The United States of America; 118; 21; 5-2021 0027-8424 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/http://www.pnas.org/lookup/doi/10.1073/pnas.2020389118 info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2020389118
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	National Academy of Sciences
publisher.none.fl_str_mv	National Academy of Sciences
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_	1842269886841094144
score	13.13397

Short hydrogen bonds enhance nonaromatic protein-related fluorescence

Publicaciones similares