Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage c...

Autores: Talwar, G. P.; Gupta, J. C.; Hada, R. S.; Nand, N. K.; Vyas, S. P.; Vyas, H. K.; Rulli, Susana Beatriz
Año de publicación: 2016
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The making of initial and progressively better, more immunogenic vaccines against hCG is briefly reviewed. Phase I Clinical trials in India, Finland, Sweden, Chile and Brazil have shown the safety and reversibility of the vaccine. Phase II trials have shown that anti-hCG antibodies above 50ng/ml titres prevent pregnancy in sexually active women without impairment of ovulation and derangement of menstrual regularity. A recombinant anti-hCG has been developed, which is expressed as DNA and protein. Priming with DNA followed by proteinic boosters of the vaccine induces very high titres of antihCG antibodies in mice. Extensive toxicology studies in rodent and marmosets have shown the safety of the recombinant vaccine. Besides contraception, the vaccine may find applications in therapy of terminal drugs-resistant cancers expressing hCG ectopically.
Fil: Talwar, G. P.. Talwar Foundation; India
Fil: Gupta, J. C.. Texas Biomedical Research Institute. Department of Virology and Immunology; India
Fil: Hada, R. S.. Talwar Foundation; India
Fil: Nand, N. K.. Talwar Foundation; India
Fil: Vyas, S. P.. Texas Biomedical Research Institute. Department of Virology and Immunology; India
Fil: Vyas, H. K.. Alpha Diagnostic International; Estados Unidos
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Materia: PREVENTION OF PREGNANCY
ECTOPIC EXPRESSION OF hCG IN CANCERS
HCG-β-TT
VACCINE
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/255737

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spelling	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancersTalwar, G. P.Gupta, J. C.Hada, R. S.Nand, N. K.Vyas, S. P.Vyas, H. K.Rulli, Susana BeatrizPREVENTION OF PREGNANCYECTOPIC EXPRESSION OF hCG IN CANCERSHCG-β-TTVACCINEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The making of initial and progressively better, more immunogenic vaccines against hCG is briefly reviewed. Phase I Clinical trials in India, Finland, Sweden, Chile and Brazil have shown the safety and reversibility of the vaccine. Phase II trials have shown that anti-hCG antibodies above 50ng/ml titres prevent pregnancy in sexually active women without impairment of ovulation and derangement of menstrual regularity. A recombinant anti-hCG has been developed, which is expressed as DNA and protein. Priming with DNA followed by proteinic boosters of the vaccine induces very high titres of antihCG antibodies in mice. Extensive toxicology studies in rodent and marmosets have shown the safety of the recombinant vaccine. Besides contraception, the vaccine may find applications in therapy of terminal drugs-resistant cancers expressing hCG ectopically.Fil: Talwar, G. P.. Talwar Foundation; IndiaFil: Gupta, J. C.. Texas Biomedical Research Institute. Department of Virology and Immunology; IndiaFil: Hada, R. S.. Talwar Foundation; IndiaFil: Nand, N. K.. Talwar Foundation; IndiaFil: Vyas, S. P.. Texas Biomedical Research Institute. Department of Virology and Immunology; IndiaFil: Vyas, H. K.. Alpha Diagnostic International; Estados UnidosFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaAustin Publishing Group2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255737Talwar, G. P.; Gupta, J. C.; Hada, R. S.; Nand, N. K.; Vyas, S. P.; et al.; Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers; Austin Publishing Group; Austin Journal of Obstetrics and Gynecology; 3; 2; 2016; 1-62378-1386CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/obstetrics-gynecology/fulltext/ajog-v3-id1059.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:31:39Zoai:ri.conicet.gov.ar:11336/255737instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:31:40.287CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
title	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
spellingShingle	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers Talwar, G. P. PREVENTION OF PREGNANCY ECTOPIC EXPRESSION OF hCG IN CANCERS HCG-β-TT VACCINE
title_short	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
title_full	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
title_fullStr	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
title_full_unstemmed	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
title_sort	Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers
dc.creator.none.fl_str_mv	Talwar, G. P. Gupta, J. C. Hada, R. S. Nand, N. K. Vyas, S. P. Vyas, H. K. Rulli, Susana Beatriz
author	Talwar, G. P.
author_facet	Talwar, G. P. Gupta, J. C. Hada, R. S. Nand, N. K. Vyas, S. P. Vyas, H. K. Rulli, Susana Beatriz
author_role	author
author2	Gupta, J. C. Hada, R. S. Nand, N. K. Vyas, S. P. Vyas, H. K. Rulli, Susana Beatriz
author2_role	author author author author author author
dc.subject.none.fl_str_mv	PREVENTION OF PREGNANCY ECTOPIC EXPRESSION OF hCG IN CANCERS HCG-β-TT VACCINE
topic	PREVENTION OF PREGNANCY ECTOPIC EXPRESSION OF hCG IN CANCERS HCG-β-TT VACCINE
purl_subject.fl_str_mv	https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv	The making of initial and progressively better, more immunogenic vaccines against hCG is briefly reviewed. Phase I Clinical trials in India, Finland, Sweden, Chile and Brazil have shown the safety and reversibility of the vaccine. Phase II trials have shown that anti-hCG antibodies above 50ng/ml titres prevent pregnancy in sexually active women without impairment of ovulation and derangement of menstrual regularity. A recombinant anti-hCG has been developed, which is expressed as DNA and protein. Priming with DNA followed by proteinic boosters of the vaccine induces very high titres of antihCG antibodies in mice. Extensive toxicology studies in rodent and marmosets have shown the safety of the recombinant vaccine. Besides contraception, the vaccine may find applications in therapy of terminal drugs-resistant cancers expressing hCG ectopically. Fil: Talwar, G. P.. Talwar Foundation; India Fil: Gupta, J. C.. Texas Biomedical Research Institute. Department of Virology and Immunology; India Fil: Hada, R. S.. Talwar Foundation; India Fil: Nand, N. K.. Talwar Foundation; India Fil: Vyas, S. P.. Texas Biomedical Research Institute. Department of Virology and Immunology; India Fil: Vyas, H. K.. Alpha Diagnostic International; Estados Unidos Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
description	The making of initial and progressively better, more immunogenic vaccines against hCG is briefly reviewed. Phase I Clinical trials in India, Finland, Sweden, Chile and Brazil have shown the safety and reversibility of the vaccine. Phase II trials have shown that anti-hCG antibodies above 50ng/ml titres prevent pregnancy in sexually active women without impairment of ovulation and derangement of menstrual regularity. A recombinant anti-hCG has been developed, which is expressed as DNA and protein. Priming with DNA followed by proteinic boosters of the vaccine induces very high titres of antihCG antibodies in mice. Extensive toxicology studies in rodent and marmosets have shown the safety of the recombinant vaccine. Besides contraception, the vaccine may find applications in therapy of terminal drugs-resistant cancers expressing hCG ectopically.
publishDate	2016
dc.date.none.fl_str_mv	2016
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/255737 Talwar, G. P.; Gupta, J. C.; Hada, R. S.; Nand, N. K.; Vyas, S. P.; et al.; Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers; Austin Publishing Group; Austin Journal of Obstetrics and Gynecology; 3; 2; 2016; 1-6 2378-1386 CONICET Digital CONICET
url	http://hdl.handle.net/11336/255737
identifier_str_mv	Talwar, G. P.; Gupta, J. C.; Hada, R. S.; Nand, N. K.; Vyas, S. P.; et al.; Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage cancers; Austin Publishing Group; Austin Journal of Obstetrics and Gynecology; 3; 2; 2016; 1-6 2378-1386 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/obstetrics-gynecology/fulltext/ajog-v3-id1059.php
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Austin Publishing Group
publisher.none.fl_str_mv	Austin Publishing Group
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
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repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.22299

Human Chorionic Gonadotropin is an ideal target for immuno-contraception, development of a potential birth control vaccine with additional use for immunotherapy of advanced stage c...

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