Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels

Autores
Biglione, Catalina; Sousa Herves, Anna; Menger, Martina; Wedepohl, Stefanie; Calderón, Marcelo; Strumia, Miriam Cristina
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The employment of nanogels (NGs) for drug delivery purposes has experienced a huge increase during thelast decades. Among the different NGs, those displaying stimuli-responsive properties are of special interest.In particular, NGs that are able to swell or shrink by the action of temperature are very promising materialsfor applications in the biomedical and biological fields. In this work we present the preparation ofthermoresponsive ethylene glycol-based NGs employing a simple and reliable ultrasonication approach.By this means, the reaction times could be shortened and the NGs formation could be performed evenat room temperature and in the presence of oxygen. The NGs have been characterized by differenttechniques and their cloud point could be tuned by changing the molar ratio between the monomers.Finally, the NGs were labelled with Rhodamine B and their cellular uptake and cytotoxicity have beenanalysed.
Fil: Biglione, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Sousa Herves, Anna . Freie Universität Berlin; Alemania
Fil: Menger, Martina . Freie Universität Berlin; Alemania
Fil: Wedepohl, Stefanie . Freie Universität Berlin; Alemania
Fil: Calderón, Marcelo . Freie Universität Berlin; Alemania
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Materia
NANOGEL
THERMOSENSITIVE
ULTRASONICATION
SOFT-SYSTEM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12645
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogelsBiglione, CatalinaSousa Herves, AnnaMenger, MartinaWedepohl, StefanieCalderón, MarceloStrumia, Miriam CristinaNANOGELTHERMOSENSITIVEULTRASONICATIONSOFT-SYSTEMhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The employment of nanogels (NGs) for drug delivery purposes has experienced a huge increase during thelast decades. Among the different NGs, those displaying stimuli-responsive properties are of special interest.In particular, NGs that are able to swell or shrink by the action of temperature are very promising materialsfor applications in the biomedical and biological fields. In this work we present the preparation ofthermoresponsive ethylene glycol-based NGs employing a simple and reliable ultrasonication approach.By this means, the reaction times could be shortened and the NGs formation could be performed evenat room temperature and in the presence of oxygen. The NGs have been characterized by differenttechniques and their cloud point could be tuned by changing the molar ratio between the monomers.Finally, the NGs were labelled with Rhodamine B and their cellular uptake and cytotoxicity have beenanalysed.Fil: Biglione, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaFil: Sousa Herves, Anna . Freie Universität Berlin; AlemaniaFil: Menger, Martina . Freie Universität Berlin; AlemaniaFil: Wedepohl, Stefanie . Freie Universität Berlin; AlemaniaFil: Calderón, Marcelo . Freie Universität Berlin; AlemaniaFil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; ArgentinaRoyal Society of Chemistry2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12645Biglione, Catalina; Sousa Herves, Anna ; Menger, Martina ; Wedepohl, Stefanie ; Calderón, Marcelo ; et al.; Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels; Royal Society of Chemistry; RSC Advances; 5; 1-2015; 15407-154132046-2069enginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c4ra15784binfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C4RA15784B#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:45Zoai:ri.conicet.gov.ar:11336/12645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:45.285CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
title Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
spellingShingle Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
Biglione, Catalina
NANOGEL
THERMOSENSITIVE
ULTRASONICATION
SOFT-SYSTEM
title_short Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
title_full Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
title_fullStr Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
title_full_unstemmed Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
title_sort Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels
dc.creator.none.fl_str_mv Biglione, Catalina
Sousa Herves, Anna
Menger, Martina
Wedepohl, Stefanie
Calderón, Marcelo
Strumia, Miriam Cristina
author Biglione, Catalina
author_facet Biglione, Catalina
Sousa Herves, Anna
Menger, Martina
Wedepohl, Stefanie
Calderón, Marcelo
Strumia, Miriam Cristina
author_role author
author2 Sousa Herves, Anna
Menger, Martina
Wedepohl, Stefanie
Calderón, Marcelo
Strumia, Miriam Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv NANOGEL
THERMOSENSITIVE
ULTRASONICATION
SOFT-SYSTEM
topic NANOGEL
THERMOSENSITIVE
ULTRASONICATION
SOFT-SYSTEM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The employment of nanogels (NGs) for drug delivery purposes has experienced a huge increase during thelast decades. Among the different NGs, those displaying stimuli-responsive properties are of special interest.In particular, NGs that are able to swell or shrink by the action of temperature are very promising materialsfor applications in the biomedical and biological fields. In this work we present the preparation ofthermoresponsive ethylene glycol-based NGs employing a simple and reliable ultrasonication approach.By this means, the reaction times could be shortened and the NGs formation could be performed evenat room temperature and in the presence of oxygen. The NGs have been characterized by differenttechniques and their cloud point could be tuned by changing the molar ratio between the monomers.Finally, the NGs were labelled with Rhodamine B and their cellular uptake and cytotoxicity have beenanalysed.
Fil: Biglione, Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
Fil: Sousa Herves, Anna . Freie Universität Berlin; Alemania
Fil: Menger, Martina . Freie Universität Berlin; Alemania
Fil: Wedepohl, Stefanie . Freie Universität Berlin; Alemania
Fil: Calderón, Marcelo . Freie Universität Berlin; Alemania
Fil: Strumia, Miriam Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
description The employment of nanogels (NGs) for drug delivery purposes has experienced a huge increase during thelast decades. Among the different NGs, those displaying stimuli-responsive properties are of special interest.In particular, NGs that are able to swell or shrink by the action of temperature are very promising materialsfor applications in the biomedical and biological fields. In this work we present the preparation ofthermoresponsive ethylene glycol-based NGs employing a simple and reliable ultrasonication approach.By this means, the reaction times could be shortened and the NGs formation could be performed evenat room temperature and in the presence of oxygen. The NGs have been characterized by differenttechniques and their cloud point could be tuned by changing the molar ratio between the monomers.Finally, the NGs were labelled with Rhodamine B and their cellular uptake and cytotoxicity have beenanalysed.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12645
Biglione, Catalina; Sousa Herves, Anna ; Menger, Martina ; Wedepohl, Stefanie ; Calderón, Marcelo ; et al.; Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels; Royal Society of Chemistry; RSC Advances; 5; 1-2015; 15407-15413
2046-2069
url http://hdl.handle.net/11336/12645
identifier_str_mv Biglione, Catalina; Sousa Herves, Anna ; Menger, Martina ; Wedepohl, Stefanie ; Calderón, Marcelo ; et al.; Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels; Royal Society of Chemistry; RSC Advances; 5; 1-2015; 15407-15413
2046-2069
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c4ra15784b
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C4RA15784B#!divAbstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613791998803968
score 13.070432

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