Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs

Autores
Wang, Huiyi; Tiwari, Neha; Orellano, María Soledad; Navarro, Lucila; Beiranvand, Zahra; Adeli, Mohsen; Calderon, Marcelo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thermoresponsive nanogels (tNGs) are promising candidates for dermal drug delivery. However, poor incorporation of hydrophobic drugs into hydrophilic tNGs limits the therapeutic efficiency. To address this challenge, β-cyclodextrins (β-CD) are functionalized by hyperbranched polyglycerol serving as crosslinkers (hPG-βCD) to fabricate βCD-tNGs. This novel construct exhibits augmented encapsulation of hydrophobic drugs, shows the appropriate thermal response to dermal administration, and enhances the dermal penetration of payloads. The structural influences on the encapsulation capacity of βCD-tNGs for hydrophobic drugs are analyzed, while concurrently retaining their efficacy as skin penetration enhancers. Various synthetic parameters are considered, encompassing the acrylation degree and molecular weight of hPG-βCD, as well as the monomer composition of βCD-tNGs. The outcome reveals that βCD-tNGs substantially enhance the aqueous solubility of Nile Red elevating to 120 µg mL−1 and augmenting its dermal penetration up to 3.33 µg cm−2. Notably, the acrylation degree of hPG-βCD plays a significant role in dermal drug penetration, primarily attributed to the impact on the rigidity and hydrophilicity of βCD-tNGs. Taken together, the introduction of the functionalized β-CD as the crosslinker in tNGs presents a novel avenue to enhance the efficacy of hydrophobic drugs in dermatological applications, thereby offering promising opportunities for boosted therapeutic outcomes.
Fil: Wang, Huiyi. Universidad del Pais Vasco. Polymat.; España
Fil: Tiwari, Neha. Universidad del Pais Vasco. Polymat.; España
Fil: Orellano, María Soledad. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Beiranvand, Zahra. Lorestan University Khorramabad; Irán
Fil: Adeli, Mohsen. Lorestan University Khorramabad; Irán
Fil: Calderon, Marcelo. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Nanogel
ciclodextrinas
nile red
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/245943
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/245943
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic DrugsWang, HuiyiTiwari, NehaOrellano, María SoledadNavarro, LucilaBeiranvand, ZahraAdeli, MohsenCalderon, MarceloNanogelciclodextrinasnile redhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Thermoresponsive nanogels (tNGs) are promising candidates for dermal drug delivery. However, poor incorporation of hydrophobic drugs into hydrophilic tNGs limits the therapeutic efficiency. To address this challenge, β-cyclodextrins (β-CD) are functionalized by hyperbranched polyglycerol serving as crosslinkers (hPG-βCD) to fabricate βCD-tNGs. This novel construct exhibits augmented encapsulation of hydrophobic drugs, shows the appropriate thermal response to dermal administration, and enhances the dermal penetration of payloads. The structural influences on the encapsulation capacity of βCD-tNGs for hydrophobic drugs are analyzed, while concurrently retaining their efficacy as skin penetration enhancers. Various synthetic parameters are considered, encompassing the acrylation degree and molecular weight of hPG-βCD, as well as the monomer composition of βCD-tNGs. The outcome reveals that βCD-tNGs substantially enhance the aqueous solubility of Nile Red elevating to 120 µg mL−1 and augmenting its dermal penetration up to 3.33 µg cm−2. Notably, the acrylation degree of hPG-βCD plays a significant role in dermal drug penetration, primarily attributed to the impact on the rigidity and hydrophilicity of βCD-tNGs. Taken together, the introduction of the functionalized β-CD as the crosslinker in tNGs presents a novel avenue to enhance the efficacy of hydrophobic drugs in dermatological applications, thereby offering promising opportunities for boosted therapeutic outcomes.Fil: Wang, Huiyi. Universidad del Pais Vasco. Polymat.; EspañaFil: Tiwari, Neha. Universidad del Pais Vasco. Polymat.; EspañaFil: Orellano, María Soledad. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Beiranvand, Zahra. Lorestan University Khorramabad; IránFil: Adeli, Mohsen. Lorestan University Khorramabad; IránFil: Calderon, Marcelo. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley VCH Verlag2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245943Wang, Huiyi; Tiwari, Neha; Orellano, María Soledad; Navarro, Lucila; Beiranvand, Zahra; et al.; Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs; Wiley VCH Verlag; Small; 20; 32; 5-2024; 1-121613-6810CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202311166info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202311166info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:39:01Zoai:ri.conicet.gov.ar:11336/245943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:39:01.64CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
title Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
spellingShingle Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
Wang, Huiyi
Nanogel
ciclodextrinas
nile red
title_short Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
title_full Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
title_fullStr Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
title_full_unstemmed Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
title_sort Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
dc.creator.none.fl_str_mv Wang, Huiyi
Tiwari, Neha
Orellano, María Soledad
Navarro, Lucila
Beiranvand, Zahra
Adeli, Mohsen
Calderon, Marcelo
author Wang, Huiyi
author_facet Wang, Huiyi
Tiwari, Neha
Orellano, María Soledad
Navarro, Lucila
Beiranvand, Zahra
Adeli, Mohsen
Calderon, Marcelo
author_role author
author2 Tiwari, Neha
Orellano, María Soledad
Navarro, Lucila
Beiranvand, Zahra
Adeli, Mohsen
Calderon, Marcelo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Nanogel
ciclodextrinas
nile red
topic Nanogel
ciclodextrinas
nile red
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Thermoresponsive nanogels (tNGs) are promising candidates for dermal drug delivery. However, poor incorporation of hydrophobic drugs into hydrophilic tNGs limits the therapeutic efficiency. To address this challenge, β-cyclodextrins (β-CD) are functionalized by hyperbranched polyglycerol serving as crosslinkers (hPG-βCD) to fabricate βCD-tNGs. This novel construct exhibits augmented encapsulation of hydrophobic drugs, shows the appropriate thermal response to dermal administration, and enhances the dermal penetration of payloads. The structural influences on the encapsulation capacity of βCD-tNGs for hydrophobic drugs are analyzed, while concurrently retaining their efficacy as skin penetration enhancers. Various synthetic parameters are considered, encompassing the acrylation degree and molecular weight of hPG-βCD, as well as the monomer composition of βCD-tNGs. The outcome reveals that βCD-tNGs substantially enhance the aqueous solubility of Nile Red elevating to 120 µg mL−1 and augmenting its dermal penetration up to 3.33 µg cm−2. Notably, the acrylation degree of hPG-βCD plays a significant role in dermal drug penetration, primarily attributed to the impact on the rigidity and hydrophilicity of βCD-tNGs. Taken together, the introduction of the functionalized β-CD as the crosslinker in tNGs presents a novel avenue to enhance the efficacy of hydrophobic drugs in dermatological applications, thereby offering promising opportunities for boosted therapeutic outcomes.
Fil: Wang, Huiyi. Universidad del Pais Vasco. Polymat.; España
Fil: Tiwari, Neha. Universidad del Pais Vasco. Polymat.; España
Fil: Orellano, María Soledad. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Beiranvand, Zahra. Lorestan University Khorramabad; Irán
Fil: Adeli, Mohsen. Lorestan University Khorramabad; Irán
Fil: Calderon, Marcelo. Universidad del Pais Vasco. Polymat.; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Thermoresponsive nanogels (tNGs) are promising candidates for dermal drug delivery. However, poor incorporation of hydrophobic drugs into hydrophilic tNGs limits the therapeutic efficiency. To address this challenge, β-cyclodextrins (β-CD) are functionalized by hyperbranched polyglycerol serving as crosslinkers (hPG-βCD) to fabricate βCD-tNGs. This novel construct exhibits augmented encapsulation of hydrophobic drugs, shows the appropriate thermal response to dermal administration, and enhances the dermal penetration of payloads. The structural influences on the encapsulation capacity of βCD-tNGs for hydrophobic drugs are analyzed, while concurrently retaining their efficacy as skin penetration enhancers. Various synthetic parameters are considered, encompassing the acrylation degree and molecular weight of hPG-βCD, as well as the monomer composition of βCD-tNGs. The outcome reveals that βCD-tNGs substantially enhance the aqueous solubility of Nile Red elevating to 120 µg mL−1 and augmenting its dermal penetration up to 3.33 µg cm−2. Notably, the acrylation degree of hPG-βCD plays a significant role in dermal drug penetration, primarily attributed to the impact on the rigidity and hydrophilicity of βCD-tNGs. Taken together, the introduction of the functionalized β-CD as the crosslinker in tNGs presents a novel avenue to enhance the efficacy of hydrophobic drugs in dermatological applications, thereby offering promising opportunities for boosted therapeutic outcomes.
publishDate 2024
dc.date.none.fl_str_mv 2024-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/245943
Wang, Huiyi; Tiwari, Neha; Orellano, María Soledad; Navarro, Lucila; Beiranvand, Zahra; et al.; Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs; Wiley VCH Verlag; Small; 20; 32; 5-2024; 1-12
1613-6810
CONICET Digital
CONICET
url http://hdl.handle.net/11336/245943
identifier_str_mv Wang, Huiyi; Tiwari, Neha; Orellano, María Soledad; Navarro, Lucila; Beiranvand, Zahra; et al.; Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs; Wiley VCH Verlag; Small; 20; 32; 5-2024; 1-12
1613-6810
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/smll.202311166
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/smll.202311166
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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