Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants

Autores
Cattalini, Juan Pablo; Boccaccini, Aldo R.; Lucangioli, Silvia Edith; Mouriño, Viviana Silvia Lourdes
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Bisphosphonates (BPs) are a group of well-established drugs applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering which is the topic of this review in which an extensive overview of published studies on the development and applications of BPs based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three dimensional (3D) bone tissue scaffolds. Different alternatives investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are discussed comprehensively and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of bisphosphonates within coatings for improved fixation of orthopaedic implants are presented and critically evaluated. Finally, the authors’ views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.
Fil: Cattalini, Juan Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
BISPHOSPHONATE
BONE TISSUE ENGINEERING
DRUG RELEASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152777
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic ImplantsCattalini, Juan PabloBoccaccini, Aldo R.Lucangioli, Silvia EdithMouriño, Viviana Silvia LourdesBISPHOSPHONATEBONE TISSUE ENGINEERINGDRUG RELEASEhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Bisphosphonates (BPs) are a group of well-established drugs applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering which is the topic of this review in which an extensive overview of published studies on the development and applications of BPs based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three dimensional (3D) bone tissue scaffolds. Different alternatives investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are discussed comprehensively and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of bisphosphonates within coatings for improved fixation of orthopaedic implants are presented and critically evaluated. Finally, the authors’ views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.Fil: Cattalini, Juan Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; AlemaniaFil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaMary Ann Liebert2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152777Cattalini, Juan Pablo; Boccaccini, Aldo R.; Lucangioli, Silvia Edith; Mouriño, Viviana Silvia Lourdes; Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants; Mary Ann Liebert; Tissue Engineering Part B-reviews; 18; 5; 9-2012; 323-3401937-3368CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/pdf/10.1089/ten.teb.2011.0737info:eu-repo/semantics/altIdentifier/doi/10.1089/ten.teb.2011.0737info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:13Zoai:ri.conicet.gov.ar:11336/152777instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:14.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
title Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
spellingShingle Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
Cattalini, Juan Pablo
BISPHOSPHONATE
BONE TISSUE ENGINEERING
DRUG RELEASE
title_short Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
title_full Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
title_fullStr Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
title_full_unstemmed Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
title_sort Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants
dc.creator.none.fl_str_mv Cattalini, Juan Pablo
Boccaccini, Aldo R.
Lucangioli, Silvia Edith
Mouriño, Viviana Silvia Lourdes
author Cattalini, Juan Pablo
author_facet Cattalini, Juan Pablo
Boccaccini, Aldo R.
Lucangioli, Silvia Edith
Mouriño, Viviana Silvia Lourdes
author_role author
author2 Boccaccini, Aldo R.
Lucangioli, Silvia Edith
Mouriño, Viviana Silvia Lourdes
author2_role author
author
author
dc.subject.none.fl_str_mv BISPHOSPHONATE
BONE TISSUE ENGINEERING
DRUG RELEASE
topic BISPHOSPHONATE
BONE TISSUE ENGINEERING
DRUG RELEASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Bisphosphonates (BPs) are a group of well-established drugs applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering which is the topic of this review in which an extensive overview of published studies on the development and applications of BPs based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three dimensional (3D) bone tissue scaffolds. Different alternatives investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are discussed comprehensively and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of bisphosphonates within coatings for improved fixation of orthopaedic implants are presented and critically evaluated. Finally, the authors’ views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.
Fil: Cattalini, Juan Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
Fil: Boccaccini, Aldo R.. Universitat Erlangen-Nuremberg; Alemania
Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Mouriño, Viviana Silvia Lourdes. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Bisphosphonates (BPs) are a group of well-established drugs applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering which is the topic of this review in which an extensive overview of published studies on the development and applications of BPs based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three dimensional (3D) bone tissue scaffolds. Different alternatives investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are discussed comprehensively and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of bisphosphonates within coatings for improved fixation of orthopaedic implants are presented and critically evaluated. Finally, the authors’ views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152777
Cattalini, Juan Pablo; Boccaccini, Aldo R.; Lucangioli, Silvia Edith; Mouriño, Viviana Silvia Lourdes; Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants; Mary Ann Liebert; Tissue Engineering Part B-reviews; 18; 5; 9-2012; 323-340
1937-3368
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152777
identifier_str_mv Cattalini, Juan Pablo; Boccaccini, Aldo R.; Lucangioli, Silvia Edith; Mouriño, Viviana Silvia Lourdes; Bisphosphonate-Based Strategies for Bone Tissue Engineering and Orthopedic Implants; Mary Ann Liebert; Tissue Engineering Part B-reviews; 18; 5; 9-2012; 323-340
1937-3368
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/pdf/10.1089/ten.teb.2011.0737
info:eu-repo/semantics/altIdentifier/doi/10.1089/ten.teb.2011.0737
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980635513192448
score 12.993085

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