Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment

Autores
Brun, Lucas Ricardo Martín; Galich, Ana M.; Vega, Eduardo; Salerni, Helena; Maffei, Laura; Premrou, Valeria; Costanzo, Paulo R; Sarli, Marcelo A; Rey, Paula; Larroudé, Maria S.; Moggia, Maria S.; Brance, María Lorena; Sánchez, Ariel; Grupo Argentino de Estudio del Ranelato de Estroncio
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and boneturnover markers after 1 year of treatment. Additionally, theeffect of SrR in bisphosphonate-naïve patients (BP-naïve)compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included482 postmenopausal women treated with SrR (2 g/day) for 1year in ten Argentine centers; 41 patients were excludeddue to insufficient data, while 441 were included. Participants were divided according to previous bisphosphonatetreatment in two groups: BP-naïve (n = 87) and BP-prior (n = 350). Data are expressed as mean ± SEM. After 1 year oftreatment with SrR the bone formation markers total alkaline phosphatase and osteocalcin were increased (p < 0.0001),while the bone resorption marker s-CTX was decreased (p =0.0579). Also increases in BMD at the lumbar spine (LS,3.73%), femoral neck (FN, 2.00%) and total hip (TH, 1.54%) [p < 0.0001] were observed. These increments were significant(p < 0.0001) both among BP-naïve and BP-prior patients. Interestingly, the change in BMD after 1 year of SrR treatmentwas higher in BP-naïve patients: LS: BP-naïve = 4.58 ± 0.62%; BP-prior = 3.45 ± 0.28% (p = 0.078). FN: BP-naïve = 2.79 ±0.56%; BP-prior = 2.13 ± 0.29% (p = 0.161). TH: BP-naïve = 3.01± 0.55%; BP-prior = 1.22 ± 0.27% (p = 0.0006). SrR treatmentincreased BMD and bone formation markers and decreaseda bone resorption marker in the whole group, with betterresponse in BP-naïve patients.
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Galich, Ana M.. Hospital Italiano; Argentina
Fil: Vega, Eduardo. Instituto de la Mujer. Buenos Aires; Argentina
Fil: Salerni, Helena. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; Argentina
Fil: Maffei, Laura. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
Fil: Premrou, Valeria. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
Fil: Costanzo, Paulo R. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; Argentina
Fil: Sarli, Marcelo A. Instituto de Investigaciones Metabólicas Dr. Zanchetta; Argentina
Fil: Rey, Paula. Instituto de Investigaciones Metabólicas Dr. Zanchetta; Argentina
Fil: Larroudé, Maria S.. Hospital César Milstein; Argentina
Fil: Moggia, Maria S.. Centro Tiempo; Argentina
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Sánchez, Ariel. Centro de Endocrinología; Argentina
Fil: Grupo Argentino de Estudio del Ranelato de Estroncio. No especifica;
Materia
Strontium ranelate
Bone mineral density
Bisphosphonate-naïve
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31065
Acceder
id CONICETDig_15fde0575a5c0afc7c5a273440931dee
oai_identifier_str oai:ri.conicet.gov.ar:11336/31065
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatmentBrun, Lucas Ricardo MartínGalich, Ana M.Vega, EduardoSalerni, HelenaMaffei, LauraPremrou, ValeriaCostanzo, Paulo RSarli, Marcelo ARey, PaulaLarroudé, Maria S.Moggia, Maria S.Brance, María LorenaSánchez, ArielGrupo Argentino de Estudio del Ranelato de EstroncioStrontium ranelateBone mineral densityBisphosphonate-naïvehttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and boneturnover markers after 1 year of treatment. Additionally, theeffect of SrR in bisphosphonate-naïve patients (BP-naïve)compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included482 postmenopausal women treated with SrR (2 g/day) for 1year in ten Argentine centers; 41 patients were excludeddue to insufficient data, while 441 were included. Participants were divided according to previous bisphosphonatetreatment in two groups: BP-naïve (n = 87) and BP-prior (n = 350). Data are expressed as mean ± SEM. After 1 year oftreatment with SrR the bone formation markers total alkaline phosphatase and osteocalcin were increased (p < 0.0001),while the bone resorption marker s-CTX was decreased (p =0.0579). Also increases in BMD at the lumbar spine (LS,3.73%), femoral neck (FN, 2.00%) and total hip (TH, 1.54%) [p < 0.0001] were observed. These increments were significant(p < 0.0001) both among BP-naïve and BP-prior patients. Interestingly, the change in BMD after 1 year of SrR treatmentwas higher in BP-naïve patients: LS: BP-naïve = 4.58 ± 0.62%; BP-prior = 3.45 ± 0.28% (p = 0.078). FN: BP-naïve = 2.79 ±0.56%; BP-prior = 2.13 ± 0.29% (p = 0.161). TH: BP-naïve = 3.01± 0.55%; BP-prior = 1.22 ± 0.27% (p = 0.0006). SrR treatmentincreased BMD and bone formation markers and decreaseda bone resorption marker in the whole group, with betterresponse in BP-naïve patients.Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Galich, Ana M.. Hospital Italiano; ArgentinaFil: Vega, Eduardo. Instituto de la Mujer. Buenos Aires; ArgentinaFil: Salerni, Helena. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; ArgentinaFil: Maffei, Laura. Consultorios Asociados de Endocrinología Dra. Laura Maffei; ArgentinaFil: Premrou, Valeria. Consultorios Asociados de Endocrinología Dra. Laura Maffei; ArgentinaFil: Costanzo, Paulo R. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; ArgentinaFil: Sarli, Marcelo A. Instituto de Investigaciones Metabólicas Dr. Zanchetta; ArgentinaFil: Rey, Paula. Instituto de Investigaciones Metabólicas Dr. Zanchetta; ArgentinaFil: Larroudé, Maria S.. Hospital César Milstein; ArgentinaFil: Moggia, Maria S.. Centro Tiempo; ArgentinaFil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; ArgentinaFil: Sánchez, Ariel. Centro de Endocrinología; ArgentinaFil: Grupo Argentino de Estudio del Ranelato de Estroncio. No especifica;Springer2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31065Grupo Argentino de Estudio del Ranelato de Estroncio; Sánchez, Ariel; Brance, María Lorena; Moggia, Maria S.; Larroudé, Maria S.; Rey, Paula; et al.; Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment; Springer; SpringerPlus; 11-20142193-1801CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/2193-1801-3-676info:eu-repo/semantics/altIdentifier/url/https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-676info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:02Zoai:ri.conicet.gov.ar:11336/31065instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:02.754CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
title Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
spellingShingle Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
Brun, Lucas Ricardo Martín
Strontium ranelate
Bone mineral density
Bisphosphonate-naïve
title_short Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
title_full Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
title_fullStr Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
title_full_unstemmed Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
title_sort Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment
dc.creator.none.fl_str_mv Brun, Lucas Ricardo Martín
Galich, Ana M.
Vega, Eduardo
Salerni, Helena
Maffei, Laura
Premrou, Valeria
Costanzo, Paulo R
Sarli, Marcelo A
Rey, Paula
Larroudé, Maria S.
Moggia, Maria S.
Brance, María Lorena
Sánchez, Ariel
Grupo Argentino de Estudio del Ranelato de Estroncio
author Brun, Lucas Ricardo Martín
author_facet Brun, Lucas Ricardo Martín
Galich, Ana M.
Vega, Eduardo
Salerni, Helena
Maffei, Laura
Premrou, Valeria
Costanzo, Paulo R
Sarli, Marcelo A
Rey, Paula
Larroudé, Maria S.
Moggia, Maria S.
Brance, María Lorena
Sánchez, Ariel
Grupo Argentino de Estudio del Ranelato de Estroncio
author_role author
author2 Galich, Ana M.
Vega, Eduardo
Salerni, Helena
Maffei, Laura
Premrou, Valeria
Costanzo, Paulo R
Sarli, Marcelo A
Rey, Paula
Larroudé, Maria S.
Moggia, Maria S.
Brance, María Lorena
Sánchez, Ariel
Grupo Argentino de Estudio del Ranelato de Estroncio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Strontium ranelate
Bone mineral density
Bisphosphonate-naïve
topic Strontium ranelate
Bone mineral density
Bisphosphonate-naïve
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and boneturnover markers after 1 year of treatment. Additionally, theeffect of SrR in bisphosphonate-naïve patients (BP-naïve)compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included482 postmenopausal women treated with SrR (2 g/day) for 1year in ten Argentine centers; 41 patients were excludeddue to insufficient data, while 441 were included. Participants were divided according to previous bisphosphonatetreatment in two groups: BP-naïve (n = 87) and BP-prior (n = 350). Data are expressed as mean ± SEM. After 1 year oftreatment with SrR the bone formation markers total alkaline phosphatase and osteocalcin were increased (p < 0.0001),while the bone resorption marker s-CTX was decreased (p =0.0579). Also increases in BMD at the lumbar spine (LS,3.73%), femoral neck (FN, 2.00%) and total hip (TH, 1.54%) [p < 0.0001] were observed. These increments were significant(p < 0.0001) both among BP-naïve and BP-prior patients. Interestingly, the change in BMD after 1 year of SrR treatmentwas higher in BP-naïve patients: LS: BP-naïve = 4.58 ± 0.62%; BP-prior = 3.45 ± 0.28% (p = 0.078). FN: BP-naïve = 2.79 ±0.56%; BP-prior = 2.13 ± 0.29% (p = 0.161). TH: BP-naïve = 3.01± 0.55%; BP-prior = 1.22 ± 0.27% (p = 0.0006). SrR treatmentincreased BMD and bone formation markers and decreaseda bone resorption marker in the whole group, with betterresponse in BP-naïve patients.
Fil: Brun, Lucas Ricardo Martín. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Galich, Ana M.. Hospital Italiano; Argentina
Fil: Vega, Eduardo. Instituto de la Mujer. Buenos Aires; Argentina
Fil: Salerni, Helena. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; Argentina
Fil: Maffei, Laura. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
Fil: Premrou, Valeria. Consultorios Asociados de Endocrinología Dra. Laura Maffei; Argentina
Fil: Costanzo, Paulo R. Consultorios de Investigación Clínica Endocrinológica y del Metabolismo Óseo ; Argentina
Fil: Sarli, Marcelo A. Instituto de Investigaciones Metabólicas Dr. Zanchetta; Argentina
Fil: Rey, Paula. Instituto de Investigaciones Metabólicas Dr. Zanchetta; Argentina
Fil: Larroudé, Maria S.. Hospital César Milstein; Argentina
Fil: Moggia, Maria S.. Centro Tiempo; Argentina
Fil: Brance, María Lorena. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Ósea; Argentina
Fil: Sánchez, Ariel. Centro de Endocrinología; Argentina
Fil: Grupo Argentino de Estudio del Ranelato de Estroncio. No especifica;
description The aim of this study was to evaluate the effect of strontium ranelate (SrR) on bone mineral density (BMD) and boneturnover markers after 1 year of treatment. Additionally, theeffect of SrR in bisphosphonate-naïve patients (BP-naïve)compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included482 postmenopausal women treated with SrR (2 g/day) for 1year in ten Argentine centers; 41 patients were excludeddue to insufficient data, while 441 were included. Participants were divided according to previous bisphosphonatetreatment in two groups: BP-naïve (n = 87) and BP-prior (n = 350). Data are expressed as mean ± SEM. After 1 year oftreatment with SrR the bone formation markers total alkaline phosphatase and osteocalcin were increased (p < 0.0001),while the bone resorption marker s-CTX was decreased (p =0.0579). Also increases in BMD at the lumbar spine (LS,3.73%), femoral neck (FN, 2.00%) and total hip (TH, 1.54%) [p < 0.0001] were observed. These increments were significant(p < 0.0001) both among BP-naïve and BP-prior patients. Interestingly, the change in BMD after 1 year of SrR treatmentwas higher in BP-naïve patients: LS: BP-naïve = 4.58 ± 0.62%; BP-prior = 3.45 ± 0.28% (p = 0.078). FN: BP-naïve = 2.79 ±0.56%; BP-prior = 2.13 ± 0.29% (p = 0.161). TH: BP-naïve = 3.01± 0.55%; BP-prior = 1.22 ± 0.27% (p = 0.0006). SrR treatmentincreased BMD and bone formation markers and decreaseda bone resorption marker in the whole group, with betterresponse in BP-naïve patients.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31065
Grupo Argentino de Estudio del Ranelato de Estroncio; Sánchez, Ariel; Brance, María Lorena; Moggia, Maria S.; Larroudé, Maria S.; Rey, Paula; et al.; Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment; Springer; SpringerPlus; 11-2014
2193-1801
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31065
identifier_str_mv Grupo Argentino de Estudio del Ranelato de Estroncio; Sánchez, Ariel; Brance, María Lorena; Moggia, Maria S.; Larroudé, Maria S.; Rey, Paula; et al.; Strontium ranelate effect on bone mineral density is modified by previous bisphosphonate treatment; Springer; SpringerPlus; 11-2014
2193-1801
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/2193-1801-3-676
info:eu-repo/semantics/altIdentifier/url/https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-676
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269069057720320
score 13.13397

Publicaciones similares