Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats

Autores
Schroyens, Natalie; Bender, Crhistian Luis; Alfei Palloni, Joaquin Matías; Molina, Víctor Alejandro; Luyten, Laura; Beckers, Tom
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study aimed to investigate the influence of housing conditions on contextual fear memory malleability. Male Wistar rats were housed in enriched, standard, or impoverished conditions after weaning and remained in these conditions throughout the entire experiment. After six weeks into those housing conditions, all animals underwent a 3-day protocol including contextual fear conditioning (day 1), memory reactivation followed by systemic administration of midazolam or vehicle (day 2), and a retention test (day 3). Percentage freezing was used as a behavioral measure of contextual fear. There was no evidence for an effect of housing conditions on the sensitivity of contextual fear memory to amnestic effects of post-reactivation midazolam administration, and no indication for amnestic effects of post-reactivation midazolam overall (including in the standard group). The inability to replicate previous demonstrations of post-reactivation amnesia using the same protocol underscores the subtle nature of post-reactivation pharmacological memory interference. Notably, impoverished housing resulted in a decrease in contextual freezing during contextual fear conditioning, reactivation and retention testing, compared to enriched and standard housing conditions. This observation warrants caution when interpreting the results from experiments regarding effects of housing on fear memory processes, particularly when freezing is used as a measure of fear.
Fil: Schroyens, Natalie. Katholikie Universiteit Leuven; Bélgica
Fil: Bender, Crhistian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Alfei Palloni, Joaquin Matías. Katholikie Universiteit Leuven; Bélgica
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Luyten, Laura. Katholikie Universiteit Leuven; Bélgica
Fil: Beckers, Tom. Katholikie Universiteit Leuven; Bélgica
Materia
CONTEXTUAL FEAR CONDITIONING
ENRICHED HOUSING
FREEZING
IMPOVERISHED HOUSING
POST-REACTIVATION AMNESIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/89649
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/89649
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Post-weaning housing conditions influence freezing during contextual fear conditioning in adult ratsSchroyens, NatalieBender, Crhistian LuisAlfei Palloni, Joaquin MatíasMolina, Víctor AlejandroLuyten, LauraBeckers, TomCONTEXTUAL FEAR CONDITIONINGENRICHED HOUSINGFREEZINGIMPOVERISHED HOUSINGPOST-REACTIVATION AMNESIAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study aimed to investigate the influence of housing conditions on contextual fear memory malleability. Male Wistar rats were housed in enriched, standard, or impoverished conditions after weaning and remained in these conditions throughout the entire experiment. After six weeks into those housing conditions, all animals underwent a 3-day protocol including contextual fear conditioning (day 1), memory reactivation followed by systemic administration of midazolam or vehicle (day 2), and a retention test (day 3). Percentage freezing was used as a behavioral measure of contextual fear. There was no evidence for an effect of housing conditions on the sensitivity of contextual fear memory to amnestic effects of post-reactivation midazolam administration, and no indication for amnestic effects of post-reactivation midazolam overall (including in the standard group). The inability to replicate previous demonstrations of post-reactivation amnesia using the same protocol underscores the subtle nature of post-reactivation pharmacological memory interference. Notably, impoverished housing resulted in a decrease in contextual freezing during contextual fear conditioning, reactivation and retention testing, compared to enriched and standard housing conditions. This observation warrants caution when interpreting the results from experiments regarding effects of housing on fear memory processes, particularly when freezing is used as a measure of fear.Fil: Schroyens, Natalie. Katholikie Universiteit Leuven; BélgicaFil: Bender, Crhistian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Alfei Palloni, Joaquin Matías. Katholikie Universiteit Leuven; BélgicaFil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Luyten, Laura. Katholikie Universiteit Leuven; BélgicaFil: Beckers, Tom. Katholikie Universiteit Leuven; BélgicaElsevier Science2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89649Schroyens, Natalie; Bender, Crhistian Luis; Alfei Palloni, Joaquin Matías; Molina, Víctor Alejandro; Luyten, Laura; et al.; Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats; Elsevier Science; Behavioural Brain Research; 359; 11-2018; 172-1800166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2018.10.040info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818313068info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:17:24Zoai:ri.conicet.gov.ar:11336/89649instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:17:25.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
title Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
spellingShingle Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
Schroyens, Natalie
CONTEXTUAL FEAR CONDITIONING
ENRICHED HOUSING
FREEZING
IMPOVERISHED HOUSING
POST-REACTIVATION AMNESIA
title_short Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
title_full Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
title_fullStr Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
title_full_unstemmed Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
title_sort Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats
dc.creator.none.fl_str_mv Schroyens, Natalie
Bender, Crhistian Luis
Alfei Palloni, Joaquin Matías
Molina, Víctor Alejandro
Luyten, Laura
Beckers, Tom
author Schroyens, Natalie
author_facet Schroyens, Natalie
Bender, Crhistian Luis
Alfei Palloni, Joaquin Matías
Molina, Víctor Alejandro
Luyten, Laura
Beckers, Tom
author_role author
author2 Bender, Crhistian Luis
Alfei Palloni, Joaquin Matías
Molina, Víctor Alejandro
Luyten, Laura
Beckers, Tom
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv CONTEXTUAL FEAR CONDITIONING
ENRICHED HOUSING
FREEZING
IMPOVERISHED HOUSING
POST-REACTIVATION AMNESIA
topic CONTEXTUAL FEAR CONDITIONING
ENRICHED HOUSING
FREEZING
IMPOVERISHED HOUSING
POST-REACTIVATION AMNESIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present study aimed to investigate the influence of housing conditions on contextual fear memory malleability. Male Wistar rats were housed in enriched, standard, or impoverished conditions after weaning and remained in these conditions throughout the entire experiment. After six weeks into those housing conditions, all animals underwent a 3-day protocol including contextual fear conditioning (day 1), memory reactivation followed by systemic administration of midazolam or vehicle (day 2), and a retention test (day 3). Percentage freezing was used as a behavioral measure of contextual fear. There was no evidence for an effect of housing conditions on the sensitivity of contextual fear memory to amnestic effects of post-reactivation midazolam administration, and no indication for amnestic effects of post-reactivation midazolam overall (including in the standard group). The inability to replicate previous demonstrations of post-reactivation amnesia using the same protocol underscores the subtle nature of post-reactivation pharmacological memory interference. Notably, impoverished housing resulted in a decrease in contextual freezing during contextual fear conditioning, reactivation and retention testing, compared to enriched and standard housing conditions. This observation warrants caution when interpreting the results from experiments regarding effects of housing on fear memory processes, particularly when freezing is used as a measure of fear.
Fil: Schroyens, Natalie. Katholikie Universiteit Leuven; Bélgica
Fil: Bender, Crhistian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Alfei Palloni, Joaquin Matías. Katholikie Universiteit Leuven; Bélgica
Fil: Molina, Víctor Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentina
Fil: Luyten, Laura. Katholikie Universiteit Leuven; Bélgica
Fil: Beckers, Tom. Katholikie Universiteit Leuven; Bélgica
description The present study aimed to investigate the influence of housing conditions on contextual fear memory malleability. Male Wistar rats were housed in enriched, standard, or impoverished conditions after weaning and remained in these conditions throughout the entire experiment. After six weeks into those housing conditions, all animals underwent a 3-day protocol including contextual fear conditioning (day 1), memory reactivation followed by systemic administration of midazolam or vehicle (day 2), and a retention test (day 3). Percentage freezing was used as a behavioral measure of contextual fear. There was no evidence for an effect of housing conditions on the sensitivity of contextual fear memory to amnestic effects of post-reactivation midazolam administration, and no indication for amnestic effects of post-reactivation midazolam overall (including in the standard group). The inability to replicate previous demonstrations of post-reactivation amnesia using the same protocol underscores the subtle nature of post-reactivation pharmacological memory interference. Notably, impoverished housing resulted in a decrease in contextual freezing during contextual fear conditioning, reactivation and retention testing, compared to enriched and standard housing conditions. This observation warrants caution when interpreting the results from experiments regarding effects of housing on fear memory processes, particularly when freezing is used as a measure of fear.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/89649
Schroyens, Natalie; Bender, Crhistian Luis; Alfei Palloni, Joaquin Matías; Molina, Víctor Alejandro; Luyten, Laura; et al.; Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats; Elsevier Science; Behavioural Brain Research; 359; 11-2018; 172-180
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/89649
identifier_str_mv Schroyens, Natalie; Bender, Crhistian Luis; Alfei Palloni, Joaquin Matías; Molina, Víctor Alejandro; Luyten, Laura; et al.; Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats; Elsevier Science; Behavioural Brain Research; 359; 11-2018; 172-180
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2018.10.040
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818313068
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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