Prediction error and trace dominance determine the fate of fear memories after post-training manipulations

Autores
Alfei Palloni, Joaquin Matías; Ferrer Monti, Roque Ignacio; Molina, Victor Alejandro; Bueno, Adrián Marcelo; Urcelay, Gonzalo Pablo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization- reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.
Fil: Alfei Palloni, Joaquin Matías. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrer Monti, Roque Ignacio. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molina, Victor Alejandro. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bueno, Adrián Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Urcelay, Gonzalo Pablo. University of Cambridge; Reino Unido
Materia
REACTIVATION
RECONSOLIDATION
MEMORY
FEAR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180178
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Prediction error and trace dominance determine the fate of fear memories after post-training manipulationsAlfei Palloni, Joaquin MatíasFerrer Monti, Roque IgnacioMolina, Victor AlejandroBueno, Adrián MarceloUrcelay, Gonzalo PabloREACTIVATIONRECONSOLIDATIONMEMORYFEARhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3https://purl.org/becyt/ford/5.1https://purl.org/becyt/ford/5Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization- reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.Fil: Alfei Palloni, Joaquin Matías. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrer Monti, Roque Ignacio. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Molina, Victor Alejandro. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bueno, Adrián Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Urcelay, Gonzalo Pablo. University of Cambridge; Reino UnidoCold Spring Harbor Laboratory Press2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180178Alfei Palloni, Joaquin Matías; Ferrer Monti, Roque Ignacio; Molina, Victor Alejandro; Bueno, Adrián Marcelo; Urcelay, Gonzalo Pablo; Prediction error and trace dominance determine the fate of fear memories after post-training manipulations; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 22; 8; 8-2015; 385-4001072-0502CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/22/8/385info:eu-repo/semantics/altIdentifier/doi/10.1101/lm.038513.115info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:23:52Zoai:ri.conicet.gov.ar:11336/180178instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:23:53.182CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
spellingShingle Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
Alfei Palloni, Joaquin Matías
REACTIVATION
RECONSOLIDATION
MEMORY
FEAR
title_short Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_full Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_fullStr Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_full_unstemmed Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
title_sort Prediction error and trace dominance determine the fate of fear memories after post-training manipulations
dc.creator.none.fl_str_mv Alfei Palloni, Joaquin Matías
Ferrer Monti, Roque Ignacio
Molina, Victor Alejandro
Bueno, Adrián Marcelo
Urcelay, Gonzalo Pablo
author Alfei Palloni, Joaquin Matías
author_facet Alfei Palloni, Joaquin Matías
Ferrer Monti, Roque Ignacio
Molina, Victor Alejandro
Bueno, Adrián Marcelo
Urcelay, Gonzalo Pablo
author_role author
author2 Ferrer Monti, Roque Ignacio
Molina, Victor Alejandro
Bueno, Adrián Marcelo
Urcelay, Gonzalo Pablo
author2_role author
author
author
author
dc.subject.none.fl_str_mv REACTIVATION
RECONSOLIDATION
MEMORY
FEAR
topic REACTIVATION
RECONSOLIDATION
MEMORY
FEAR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/5.1
https://purl.org/becyt/ford/5
dc.description.none.fl_txt_mv Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization- reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.
Fil: Alfei Palloni, Joaquin Matías. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ferrer Monti, Roque Ignacio. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Molina, Victor Alejandro. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bueno, Adrián Marcelo. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Urcelay, Gonzalo Pablo. University of Cambridge; Reino Unido
description Different mnemonic outcomes have been observed when associative memories are reactivated by CS exposure and followed by amnestics. These outcomes include mere retrieval, destabilization- reconsolidation, a transitional period (which is insensitive to amnestics), and extinction learning. However, little is known about the interaction between initial learning conditions and these outcomes during a reinforced or nonreinforced reactivation. Here we systematically combined temporally specific memories with different reactivation parameters to observe whether these four outcomes are determined by the conditions established during training. First, we validated two training regimens with different temporal expectations about US arrival. Then, using Midazolam (MDZ) as an amnestic agent, fear memories in both learning conditions were submitted to retraining either under identical or different parameters to the original training. Destabilization (i.e., susceptibly to MDZ) occurred when reactivation was reinforced, provided the occurrence of a temporal prediction error about US arrival. In subsequent experiments, both treatments were systematically reactivated by nonreinforced context exposure of different lengths, which allowed to explore the interaction between training and reactivation lengths. These results suggest that temporal prediction error and trace dominance determine the extent to which reactivation produces the different outcomes.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180178
Alfei Palloni, Joaquin Matías; Ferrer Monti, Roque Ignacio; Molina, Victor Alejandro; Bueno, Adrián Marcelo; Urcelay, Gonzalo Pablo; Prediction error and trace dominance determine the fate of fear memories after post-training manipulations; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 22; 8; 8-2015; 385-400
1072-0502
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180178
identifier_str_mv Alfei Palloni, Joaquin Matías; Ferrer Monti, Roque Ignacio; Molina, Victor Alejandro; Bueno, Adrián Marcelo; Urcelay, Gonzalo Pablo; Prediction error and trace dominance determine the fate of fear memories after post-training manipulations; Cold Spring Harbor Laboratory Press; Learning & Memory (Cold Spring Harbor, N.Y.); 22; 8; 8-2015; 385-400
1072-0502
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://learnmem.cshlp.org/content/22/8/385
info:eu-repo/semantics/altIdentifier/doi/10.1101/lm.038513.115
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083385696452608
score 13.22299

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