Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
- Autores
- Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; Zanuzzi, Carolina Natalia; Nishida, Fabian; Lavid, A.; Confente, F.; Díaz, M.; Portiansky, Enrique Leo; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Confente, F.. No especifíca;
Fil: Díaz, M.. No especifíca;
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina - Materia
-
CAT
CYCLO-OXYGENASE-2
FELINE INJECTION SITE SARCOMA
IMMUNOHISTOCHEMISTRY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/131943
Ver los metadatos del registro completo
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Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomasSantelices Iglesias, Olga AndreaWright, CarolinaDuchene, A. G.Risso, Miguel AtilioRisso, PaulaZanuzzi, Carolina NataliaNishida, FabianLavid, A.Confente, F.Díaz, M.Portiansky, Enrique LeoGimeno, Eduardo JuanBarbeito, Claudio GustavoCATCYCLO-OXYGENASE-2FELINE INJECTION SITE SARCOMAIMMUNOHISTOCHEMISTRYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Confente, F.. No especifíca;Fil: Díaz, M.. No especifíca;Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131943Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-510021-9975CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021997518301993info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:45Zoai:ri.conicet.gov.ar:11336/131943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:45.332CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
title |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
spellingShingle |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas Santelices Iglesias, Olga Andrea CAT CYCLO-OXYGENASE-2 FELINE INJECTION SITE SARCOMA IMMUNOHISTOCHEMISTRY |
title_short |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
title_full |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
title_fullStr |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
title_full_unstemmed |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
title_sort |
Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas |
dc.creator.none.fl_str_mv |
Santelices Iglesias, Olga Andrea Wright, Carolina Duchene, A. G. Risso, Miguel Atilio Risso, Paula Zanuzzi, Carolina Natalia Nishida, Fabian Lavid, A. Confente, F. Díaz, M. Portiansky, Enrique Leo Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author |
Santelices Iglesias, Olga Andrea |
author_facet |
Santelices Iglesias, Olga Andrea Wright, Carolina Duchene, A. G. Risso, Miguel Atilio Risso, Paula Zanuzzi, Carolina Natalia Nishida, Fabian Lavid, A. Confente, F. Díaz, M. Portiansky, Enrique Leo Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author_role |
author |
author2 |
Wright, Carolina Duchene, A. G. Risso, Miguel Atilio Risso, Paula Zanuzzi, Carolina Natalia Nishida, Fabian Lavid, A. Confente, F. Díaz, M. Portiansky, Enrique Leo Gimeno, Eduardo Juan Barbeito, Claudio Gustavo |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CAT CYCLO-OXYGENASE-2 FELINE INJECTION SITE SARCOMA IMMUNOHISTOCHEMISTRY |
topic |
CAT CYCLO-OXYGENASE-2 FELINE INJECTION SITE SARCOMA IMMUNOHISTOCHEMISTRY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia. Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina Fil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina Fil: Confente, F.. No especifíca; Fil: Díaz, M.. No especifíca; Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina |
description |
Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/131943 Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-51 0021-9975 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/131943 |
identifier_str_mv |
Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-51 0021-9975 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021997518301993 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
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application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613564198813696 |
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13.070432 |