Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas

Autores
Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; Zanuzzi, Carolina Natalia; Nishida, Fabian; Lavid, A.; Confente, F.; Díaz, M.; Portiansky, Enrique Leo; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Confente, F.. No especifíca;
Fil: Díaz, M.. No especifíca;
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Materia
CAT
CYCLO-OXYGENASE-2
FELINE INJECTION SITE SARCOMA
IMMUNOHISTOCHEMISTRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/131943

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network_name_str CONICET Digital (CONICET)
spelling Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomasSantelices Iglesias, Olga AndreaWright, CarolinaDuchene, A. G.Risso, Miguel AtilioRisso, PaulaZanuzzi, Carolina NataliaNishida, FabianLavid, A.Confente, F.Díaz, M.Portiansky, Enrique LeoGimeno, Eduardo JuanBarbeito, Claudio GustavoCATCYCLO-OXYGENASE-2FELINE INJECTION SITE SARCOMAIMMUNOHISTOCHEMISTRYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaFil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; ArgentinaFil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Confente, F.. No especifíca;Fil: Díaz, M.. No especifíca;Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; ArgentinaElsevier2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131943Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-510021-9975CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021997518301993info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:45Zoai:ri.conicet.gov.ar:11336/131943instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:45.332CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
title Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
spellingShingle Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
Santelices Iglesias, Olga Andrea
CAT
CYCLO-OXYGENASE-2
FELINE INJECTION SITE SARCOMA
IMMUNOHISTOCHEMISTRY
title_short Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
title_full Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
title_fullStr Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
title_full_unstemmed Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
title_sort Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas
dc.creator.none.fl_str_mv Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, A. G.
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabian
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author Santelices Iglesias, Olga Andrea
author_facet Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, A. G.
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabian
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_role author
author2 Wright, Carolina
Duchene, A. G.
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabian
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CAT
CYCLO-OXYGENASE-2
FELINE INJECTION SITE SARCOMA
IMMUNOHISTOCHEMISTRY
topic CAT
CYCLO-OXYGENASE-2
FELINE INJECTION SITE SARCOMA
IMMUNOHISTOCHEMISTRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
Fil: Santelices Iglesias, Olga Andrea. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Wright, Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Duchene, A. G.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Miguel Atilio. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
Fil: Risso, Paula. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo; Argentina
Fil: Zanuzzi, Carolina Natalia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Nishida, Fabian. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Lavid, A.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Confente, F.. No especifíca;
Fil: Díaz, M.. No especifíca;
Fil: Portiansky, Enrique Leo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología General Veterinaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina
description Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/131943
Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-51
0021-9975
CONICET Digital
CONICET
url http://hdl.handle.net/11336/131943
identifier_str_mv Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, A. G.; Risso, Miguel Atilio; Risso, Paula; et al.; Association between degree of anaplasia and degree of inflammation with the expression of COX-2 in feline injection site sarcomas; Elsevier; Journal Of Comparative Pathology; 165; 11-2018; 45-51
0021-9975
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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