Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas

Autores
Santelices Iglesias, Olga Andrea; Wright, Carolina; Duchene, Adriana Graciela; Risso, Miguel Atilio; Risso, Paula; Zanuzzi, Carolina Natalia; Nishida, Fabián; Lavid, A.; Confente, F.; Díaz, M.; Portiansky, Enrique Leo; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/167606
Acceder
id SEDICI_7726539d5fa630cd287d9bcf6d7d8699
oai_identifier_str oai:sedici.unlp.edu.ar:10915/167606
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site SarcomasSantelices Iglesias, Olga AndreaWright, CarolinaDuchene, Adriana GracielaRisso, Miguel AtilioRisso, PaulaZanuzzi, Carolina NataliaNishida, FabiánLavid, A.Confente, F.Díaz, M.Portiansky, Enrique LeoGimeno, Eduardo JuanBarbeito, Claudio GustavoCiencias VeterinariasCatCyclo-oxygenase-2Feline injection site sarcomaImmunohistochemistryFeline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.Facultad de Ciencias Veterinarias2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf45-51http://sedici.unlp.edu.ar/handle/10915/167606enginfo:eu-repo/semantics/altIdentifier/issn/0021-9975info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:44:36Zoai:sedici.unlp.edu.ar:10915/167606Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:44:36.872SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
spellingShingle Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
Santelices Iglesias, Olga Andrea
Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
title_short Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_full Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_fullStr Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_full_unstemmed Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
title_sort Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas
dc.creator.none.fl_str_mv Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author Santelices Iglesias, Olga Andrea
author_facet Santelices Iglesias, Olga Andrea
Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_role author
author2 Wright, Carolina
Duchene, Adriana Graciela
Risso, Miguel Atilio
Risso, Paula
Zanuzzi, Carolina Natalia
Nishida, Fabián
Lavid, A.
Confente, F.
Díaz, M.
Portiansky, Enrique Leo
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
topic Ciencias Veterinarias
Cat
Cyclo-oxygenase-2
Feline injection site sarcoma
Immunohistochemistry
dc.description.none.fl_txt_mv Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
Facultad de Ciencias Veterinarias
description Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)- 2 is well known and its overexpression has prognostic value in multiple neoplastic processes. One hundred and seventeen FISSs were evaluated for the degree of inflammation and anaplasia. Immunohistochemistry was used to determine the expression of COX-2 in these sarcomas. There was a significant association between the degree of inflammation and the expression of COX-2 by neoplastic cells. COX-2 expression was lower in tumours with higher degrees of anaplasia. These findings may be useful in predicting the sensitivity of FISSs to treatment with COX-2 inhibitors. The potential therapeutic use of such agents could then be restricted to tumours with lower degrees of anaplasia.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/167606
url http://sedici.unlp.edu.ar/handle/10915/167606
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0021-9975
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jcpa.2018.09.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
45-51
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1844616313275678720
score 13.070432

Publicaciones similares