Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
- Autores
- Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; Barbieri, M. Alejandro
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.
Fil: Priestap, Horacio A.. Florida International University; Estados Unidos
Fil: Galvis, Adriana. Florida International University; Estados Unidos
Fil: Rivero, Nathalie. Florida International University; Estados Unidos
Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Barbieri, M. Alejandro. Florida International University; Estados Unidos - Materia
-
ARTEMISIA DOUGLASIANA BESSER
B16 MELANOMA CELLS
MELAN-A
MIGRATION
PROLIFERATION
SESQUITERPENES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/142108
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/142108 |
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CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cellsPriestap, Horacio A.Galvis, AdrianaRivero, NathalieCostantino, Valeria VictoriaLopez, Luis AlbertoBarbieri, M. AlejandroARTEMISIA DOUGLASIANA BESSERB16 MELANOMA CELLSMELAN-AMIGRATIONPROLIFERATIONSESQUITERPENEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.Fil: Priestap, Horacio A.. Florida International University; Estados UnidosFil: Galvis, Adriana. Florida International University; Estados UnidosFil: Rivero, Nathalie. Florida International University; Estados UnidosFil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Barbieri, M. Alejandro. Florida International University; Estados UnidosElsevier Science2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142108Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-5851874-3900CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytol.2012.05.018info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1874390012001127info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:20:05Zoai:ri.conicet.gov.ar:11336/142108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:20:05.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
title |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
spellingShingle |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells Priestap, Horacio A. ARTEMISIA DOUGLASIANA BESSER B16 MELANOMA CELLS MELAN-A MIGRATION PROLIFERATION SESQUITERPENES |
title_short |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
title_full |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
title_fullStr |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
title_full_unstemmed |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
title_sort |
Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells |
dc.creator.none.fl_str_mv |
Priestap, Horacio A. Galvis, Adriana Rivero, Nathalie Costantino, Valeria Victoria Lopez, Luis Alberto Barbieri, M. Alejandro |
author |
Priestap, Horacio A. |
author_facet |
Priestap, Horacio A. Galvis, Adriana Rivero, Nathalie Costantino, Valeria Victoria Lopez, Luis Alberto Barbieri, M. Alejandro |
author_role |
author |
author2 |
Galvis, Adriana Rivero, Nathalie Costantino, Valeria Victoria Lopez, Luis Alberto Barbieri, M. Alejandro |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
ARTEMISIA DOUGLASIANA BESSER B16 MELANOMA CELLS MELAN-A MIGRATION PROLIFERATION SESQUITERPENES |
topic |
ARTEMISIA DOUGLASIANA BESSER B16 MELANOMA CELLS MELAN-A MIGRATION PROLIFERATION SESQUITERPENES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas. Fil: Priestap, Horacio A.. Florida International University; Estados Unidos Fil: Galvis, Adriana. Florida International University; Estados Unidos Fil: Rivero, Nathalie. Florida International University; Estados Unidos Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Barbieri, M. Alejandro. Florida International University; Estados Unidos |
description |
Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/142108 Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-585 1874-3900 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/142108 |
identifier_str_mv |
Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-585 1874-3900 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytol.2012.05.018 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1874390012001127 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083349779578880 |
score |
13.22299 |