Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells

Autores
Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; Barbieri, M. Alejandro
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.
Fil: Priestap, Horacio A.. Florida International University; Estados Unidos
Fil: Galvis, Adriana. Florida International University; Estados Unidos
Fil: Rivero, Nathalie. Florida International University; Estados Unidos
Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Barbieri, M. Alejandro. Florida International University; Estados Unidos
Materia
ARTEMISIA DOUGLASIANA BESSER
B16 MELANOMA CELLS
MELAN-A
MIGRATION
PROLIFERATION
SESQUITERPENES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142108

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network_name_str CONICET Digital (CONICET)
spelling Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cellsPriestap, Horacio A.Galvis, AdrianaRivero, NathalieCostantino, Valeria VictoriaLopez, Luis AlbertoBarbieri, M. AlejandroARTEMISIA DOUGLASIANA BESSERB16 MELANOMA CELLSMELAN-AMIGRATIONPROLIFERATIONSESQUITERPENEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.Fil: Priestap, Horacio A.. Florida International University; Estados UnidosFil: Galvis, Adriana. Florida International University; Estados UnidosFil: Rivero, Nathalie. Florida International University; Estados UnidosFil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Barbieri, M. Alejandro. Florida International University; Estados UnidosElsevier Science2012-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142108Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-5851874-3900CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytol.2012.05.018info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1874390012001127info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:20:05Zoai:ri.conicet.gov.ar:11336/142108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:20:05.842CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
title Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
spellingShingle Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
Priestap, Horacio A.
ARTEMISIA DOUGLASIANA BESSER
B16 MELANOMA CELLS
MELAN-A
MIGRATION
PROLIFERATION
SESQUITERPENES
title_short Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
title_full Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
title_fullStr Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
title_full_unstemmed Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
title_sort Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells
dc.creator.none.fl_str_mv Priestap, Horacio A.
Galvis, Adriana
Rivero, Nathalie
Costantino, Valeria Victoria
Lopez, Luis Alberto
Barbieri, M. Alejandro
author Priestap, Horacio A.
author_facet Priestap, Horacio A.
Galvis, Adriana
Rivero, Nathalie
Costantino, Valeria Victoria
Lopez, Luis Alberto
Barbieri, M. Alejandro
author_role author
author2 Galvis, Adriana
Rivero, Nathalie
Costantino, Valeria Victoria
Lopez, Luis Alberto
Barbieri, M. Alejandro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ARTEMISIA DOUGLASIANA BESSER
B16 MELANOMA CELLS
MELAN-A
MIGRATION
PROLIFERATION
SESQUITERPENES
topic ARTEMISIA DOUGLASIANA BESSER
B16 MELANOMA CELLS
MELAN-A
MIGRATION
PROLIFERATION
SESQUITERPENES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.
Fil: Priestap, Horacio A.. Florida International University; Estados Unidos
Fil: Galvis, Adriana. Florida International University; Estados Unidos
Fil: Rivero, Nathalie. Florida International University; Estados Unidos
Fil: Costantino, Valeria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Lopez, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Barbieri, M. Alejandro. Florida International University; Estados Unidos
description Dehydroleucodine, a known sesquiterpene lactone, and dehydroparishin-B, a new guaiane type sesquiterpene acid, were isolated from aerial parts of Artemisia douglasiana by chloroform extraction. We identified dehydroparishin-B as (7R)-2-oxo-guaia-1(10),3(4),5(6),11(13)-tetraen-12-oic acid by MS and NMR methods. We demonstrated that both dehydroparishin-B and dehydroleucodine blocked cell proliferation of B16 melanoma cells, but not normal murine Melan-A melanocytes, in a dose-dependent manner without affecting cell viability. We also found that both dehydroparishin-B and dehydroleucodine inhibited migration of B16 melanoma cells. These results suggest that dehydroleucodine and dehydroparishin-B could represent potential candidates for the treatment of metastatic melanomas.
publishDate 2012
dc.date.none.fl_str_mv 2012-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142108
Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-585
1874-3900
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142108
identifier_str_mv Priestap, Horacio A.; Galvis, Adriana; Rivero, Nathalie; Costantino, Valeria Victoria; Lopez, Luis Alberto; et al.; Dehydroleucodine and dehydroparishin-B inhibit proliferation and motility of B16 melanoma cells; Elsevier Science; Phytochemistry Letters; 5; 3; 5-2012; 581-585
1874-3900
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.phytol.2012.05.018
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1874390012001127
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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