In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach
- Autores
- Silva, Luciana Damacena; Lima, Nayana Ferreira; Arrua, Eva Carolina; Salomon, Claudio Javier; Vinaud, Marina Clare
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Thus, the aim of this work was to analyze, for the first time, whether the nanoformulations of praziquantel would modify the energetic pathway of Taenia crassiceps cysticerci, after an intracranial inoculation in BALB/c mice. Praziquantel nanosuspensions were formulated with polyvinyl alcohol, poloxamer 188, and poloxamer 407, as stabilizers. These formulations exhibited particle size in a range of 74–285 nm and zeta potential values in a range of − 8.1/− 13.2 depending on the type of stabilizer. Physical stability study at both 4 ± 2 and 25 ± 2 °C indicated that praziquantel (PZQ) nanoparticles were stable in terms of solubility and particle size after 120-day storage. In vivo studies demonstrated that those nanosystems were able to produce significant modifications on the concentrations of oxaloacetate, citrate, pyruvate, alpha-ketoglutarate, malate, succinate, lactate, beta-hydroxybutyrate, fumarate, and propionate involved in the metabolism of Taenia crassiceps cysticerci. Therefore, these nanoformulations may be considered as a promising tool to deliver praziquantel to the brain for the effective management of neurocysticercosis.
Fil: Silva, Luciana Damacena. Universidade Federal de Goiás; Brasil
Fil: Lima, Nayana Ferreira. Universidade Federal de Goiás; Brasil
Fil: Arrua, Eva Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Vinaud, Marina Clare. Universidade Federal de Goiás; Brasil - Materia
-
IN VIVO
NANOTECHNOLOGY
NEUROCYSTICERCOSIS
PRAZIQUANTEL
TAENIA CRASSICEPS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/89703
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
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In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approachSilva, Luciana DamacenaLima, Nayana FerreiraArrua, Eva CarolinaSalomon, Claudio JavierVinaud, Marina ClareIN VIVONANOTECHNOLOGYNEUROCYSTICERCOSISPRAZIQUANTELTAENIA CRASSICEPShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Thus, the aim of this work was to analyze, for the first time, whether the nanoformulations of praziquantel would modify the energetic pathway of Taenia crassiceps cysticerci, after an intracranial inoculation in BALB/c mice. Praziquantel nanosuspensions were formulated with polyvinyl alcohol, poloxamer 188, and poloxamer 407, as stabilizers. These formulations exhibited particle size in a range of 74–285 nm and zeta potential values in a range of − 8.1/− 13.2 depending on the type of stabilizer. Physical stability study at both 4 ± 2 and 25 ± 2 °C indicated that praziquantel (PZQ) nanoparticles were stable in terms of solubility and particle size after 120-day storage. In vivo studies demonstrated that those nanosystems were able to produce significant modifications on the concentrations of oxaloacetate, citrate, pyruvate, alpha-ketoglutarate, malate, succinate, lactate, beta-hydroxybutyrate, fumarate, and propionate involved in the metabolism of Taenia crassiceps cysticerci. Therefore, these nanoformulations may be considered as a promising tool to deliver praziquantel to the brain for the effective management of neurocysticercosis.Fil: Silva, Luciana Damacena. Universidade Federal de Goiás; BrasilFil: Lima, Nayana Ferreira. Universidade Federal de Goiás; BrasilFil: Arrua, Eva Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Vinaud, Marina Clare. Universidade Federal de Goiás; BrasilSpringer Verlag Berlín2018-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/89703Silva, Luciana Damacena; Lima, Nayana Ferreira; Arrua, Eva Carolina; Salomon, Claudio Javier; Vinaud, Marina Clare; In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach; Springer Verlag Berlín; Drug Delivery and Translational Research; 8; 5; 10-2018; 1265-12732190-393X2190-3948CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13346-018-0576-7info:eu-repo/semantics/altIdentifier/doi/10.1007/s13346-018-0576-7info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:56Zoai:ri.conicet.gov.ar:11336/89703instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:56.998CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
title |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
spellingShingle |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach Silva, Luciana Damacena IN VIVO NANOTECHNOLOGY NEUROCYSTICERCOSIS PRAZIQUANTEL TAENIA CRASSICEPS |
title_short |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
title_full |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
title_fullStr |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
title_full_unstemmed |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
title_sort |
In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach |
dc.creator.none.fl_str_mv |
Silva, Luciana Damacena Lima, Nayana Ferreira Arrua, Eva Carolina Salomon, Claudio Javier Vinaud, Marina Clare |
author |
Silva, Luciana Damacena |
author_facet |
Silva, Luciana Damacena Lima, Nayana Ferreira Arrua, Eva Carolina Salomon, Claudio Javier Vinaud, Marina Clare |
author_role |
author |
author2 |
Lima, Nayana Ferreira Arrua, Eva Carolina Salomon, Claudio Javier Vinaud, Marina Clare |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
IN VIVO NANOTECHNOLOGY NEUROCYSTICERCOSIS PRAZIQUANTEL TAENIA CRASSICEPS |
topic |
IN VIVO NANOTECHNOLOGY NEUROCYSTICERCOSIS PRAZIQUANTEL TAENIA CRASSICEPS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.10 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Thus, the aim of this work was to analyze, for the first time, whether the nanoformulations of praziquantel would modify the energetic pathway of Taenia crassiceps cysticerci, after an intracranial inoculation in BALB/c mice. Praziquantel nanosuspensions were formulated with polyvinyl alcohol, poloxamer 188, and poloxamer 407, as stabilizers. These formulations exhibited particle size in a range of 74–285 nm and zeta potential values in a range of − 8.1/− 13.2 depending on the type of stabilizer. Physical stability study at both 4 ± 2 and 25 ± 2 °C indicated that praziquantel (PZQ) nanoparticles were stable in terms of solubility and particle size after 120-day storage. In vivo studies demonstrated that those nanosystems were able to produce significant modifications on the concentrations of oxaloacetate, citrate, pyruvate, alpha-ketoglutarate, malate, succinate, lactate, beta-hydroxybutyrate, fumarate, and propionate involved in the metabolism of Taenia crassiceps cysticerci. Therefore, these nanoformulations may be considered as a promising tool to deliver praziquantel to the brain for the effective management of neurocysticercosis. Fil: Silva, Luciana Damacena. Universidade Federal de Goiás; Brasil Fil: Lima, Nayana Ferreira. Universidade Federal de Goiás; Brasil Fil: Arrua, Eva Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Vinaud, Marina Clare. Universidade Federal de Goiás; Brasil |
description |
Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Thus, the aim of this work was to analyze, for the first time, whether the nanoformulations of praziquantel would modify the energetic pathway of Taenia crassiceps cysticerci, after an intracranial inoculation in BALB/c mice. Praziquantel nanosuspensions were formulated with polyvinyl alcohol, poloxamer 188, and poloxamer 407, as stabilizers. These formulations exhibited particle size in a range of 74–285 nm and zeta potential values in a range of − 8.1/− 13.2 depending on the type of stabilizer. Physical stability study at both 4 ± 2 and 25 ± 2 °C indicated that praziquantel (PZQ) nanoparticles were stable in terms of solubility and particle size after 120-day storage. In vivo studies demonstrated that those nanosystems were able to produce significant modifications on the concentrations of oxaloacetate, citrate, pyruvate, alpha-ketoglutarate, malate, succinate, lactate, beta-hydroxybutyrate, fumarate, and propionate involved in the metabolism of Taenia crassiceps cysticerci. Therefore, these nanoformulations may be considered as a promising tool to deliver praziquantel to the brain for the effective management of neurocysticercosis. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/89703 Silva, Luciana Damacena; Lima, Nayana Ferreira; Arrua, Eva Carolina; Salomon, Claudio Javier; Vinaud, Marina Clare; In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach; Springer Verlag Berlín; Drug Delivery and Translational Research; 8; 5; 10-2018; 1265-1273 2190-393X 2190-3948 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/89703 |
identifier_str_mv |
Silva, Luciana Damacena; Lima, Nayana Ferreira; Arrua, Eva Carolina; Salomon, Claudio Javier; Vinaud, Marina Clare; In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions- a metabolic approach; Springer Verlag Berlín; Drug Delivery and Translational Research; 8; 5; 10-2018; 1265-1273 2190-393X 2190-3948 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs13346-018-0576-7 info:eu-repo/semantics/altIdentifier/doi/10.1007/s13346-018-0576-7 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer Verlag Berlín |
publisher.none.fl_str_mv |
Springer Verlag Berlín |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269003412668416 |
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13.13397 |