First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications

Autores
Martinez, Noelia Anabel; Fernández Álvarez, Fátima; Delgado, Ángel V.; Badillo García, María Luisa; Raba, Julio; Cerutti, Estela Soledad; Arias, José L.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Praziquantel (PZQ), a broad spectrum anthelmintic drug, cannot be found in acceptable dosage forms for elderly patients, paediatric patients, and for veterinary use. In fact, very little has been done up to now in the formulation of liquid dosage forms, being they always formulated for parenteral administration. To beat this important challenge, it was accomplished a comprehensive analysis of the influence of two elementary physicochemical aspects, i.e. surface thermodynamic and electrokinetic properties, on the colloidal stability of PZQ nanosuspensions. The hydrophobic character of the drug, intensely determining the flocculation curves, was confirmed by the thermodynamic characterization. The electrophoretic characterization, in combination with the sedimentation and relative absorbance versus time curves, highlighted that the electrical double layer thickness and the surface charge can play an essential role in the stability of the pharmaceutical colloid. Finally, it was demonstrated that controlling the pH values and the incorporation of electrolytes can help in formulating PZQ aqueous nanosuspensions with appropriate stability and redispersibility behaviours for pharmaceutical use.
Fil: Martinez, Noelia Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández Álvarez, Fátima. Universidad de Granada; España
Fil: Delgado, Ángel V.. Universidad de Granada; España
Fil: Badillo García, María Luisa. Universidad de Granada; España
Fil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Arias, José L.. Universidad de Granada; España
Materia
CORRELATION ZETA POTENTIAL–SEDIMENTATION
ELECTROPHORESIS
HUMAN AND VETERINARY LIQUID DOSAGE FORMS
PAEDIATRIC DRUG FORMULATIONS
PRAZIQUANTEL
SURFACE THERMODYNAMICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138054
Acceder
id CONICETDig_0be8b1d141334fc83f278b1062535687
oai_identifier_str oai:ri.conicet.gov.ar:11336/138054
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applicationsMartinez, Noelia AnabelFernández Álvarez, FátimaDelgado, Ángel V.Badillo García, María LuisaRaba, JulioCerutti, Estela SoledadArias, José L.CORRELATION ZETA POTENTIAL–SEDIMENTATIONELECTROPHORESISHUMAN AND VETERINARY LIQUID DOSAGE FORMSPAEDIATRIC DRUG FORMULATIONSPRAZIQUANTELSURFACE THERMODYNAMICShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Praziquantel (PZQ), a broad spectrum anthelmintic drug, cannot be found in acceptable dosage forms for elderly patients, paediatric patients, and for veterinary use. In fact, very little has been done up to now in the formulation of liquid dosage forms, being they always formulated for parenteral administration. To beat this important challenge, it was accomplished a comprehensive analysis of the influence of two elementary physicochemical aspects, i.e. surface thermodynamic and electrokinetic properties, on the colloidal stability of PZQ nanosuspensions. The hydrophobic character of the drug, intensely determining the flocculation curves, was confirmed by the thermodynamic characterization. The electrophoretic characterization, in combination with the sedimentation and relative absorbance versus time curves, highlighted that the electrical double layer thickness and the surface charge can play an essential role in the stability of the pharmaceutical colloid. Finally, it was demonstrated that controlling the pH values and the incorporation of electrolytes can help in formulating PZQ aqueous nanosuspensions with appropriate stability and redispersibility behaviours for pharmaceutical use.Fil: Martinez, Noelia Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Fernández Álvarez, Fátima. Universidad de Granada; EspañaFil: Delgado, Ángel V.. Universidad de Granada; EspañaFil: Badillo García, María Luisa. Universidad de Granada; EspañaFil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Arias, José L.. Universidad de Granada; EspañaTaylor & Francis2020-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138054Martinez, Noelia Anabel; Fernández Álvarez, Fátima; Delgado, Ángel V.; Badillo García, María Luisa; Raba, Julio; et al.; First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications; Taylor & Francis; Pharmaceutical Development and Technology; 25; 7; 8-2020; 892-8981083-7450CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10837450.2020.1756320info:eu-repo/semantics/altIdentifier/doi/10.1080/10837450.2020.1756320info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:00Zoai:ri.conicet.gov.ar:11336/138054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:00.611CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
title First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
spellingShingle First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
Martinez, Noelia Anabel
CORRELATION ZETA POTENTIAL–SEDIMENTATION
ELECTROPHORESIS
HUMAN AND VETERINARY LIQUID DOSAGE FORMS
PAEDIATRIC DRUG FORMULATIONS
PRAZIQUANTEL
SURFACE THERMODYNAMICS
title_short First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
title_full First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
title_fullStr First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
title_full_unstemmed First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
title_sort First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications
dc.creator.none.fl_str_mv Martinez, Noelia Anabel
Fernández Álvarez, Fátima
Delgado, Ángel V.
Badillo García, María Luisa
Raba, Julio
Cerutti, Estela Soledad
Arias, José L.
author Martinez, Noelia Anabel
author_facet Martinez, Noelia Anabel
Fernández Álvarez, Fátima
Delgado, Ángel V.
Badillo García, María Luisa
Raba, Julio
Cerutti, Estela Soledad
Arias, José L.
author_role author
author2 Fernández Álvarez, Fátima
Delgado, Ángel V.
Badillo García, María Luisa
Raba, Julio
Cerutti, Estela Soledad
Arias, José L.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CORRELATION ZETA POTENTIAL–SEDIMENTATION
ELECTROPHORESIS
HUMAN AND VETERINARY LIQUID DOSAGE FORMS
PAEDIATRIC DRUG FORMULATIONS
PRAZIQUANTEL
SURFACE THERMODYNAMICS
topic CORRELATION ZETA POTENTIAL–SEDIMENTATION
ELECTROPHORESIS
HUMAN AND VETERINARY LIQUID DOSAGE FORMS
PAEDIATRIC DRUG FORMULATIONS
PRAZIQUANTEL
SURFACE THERMODYNAMICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Praziquantel (PZQ), a broad spectrum anthelmintic drug, cannot be found in acceptable dosage forms for elderly patients, paediatric patients, and for veterinary use. In fact, very little has been done up to now in the formulation of liquid dosage forms, being they always formulated for parenteral administration. To beat this important challenge, it was accomplished a comprehensive analysis of the influence of two elementary physicochemical aspects, i.e. surface thermodynamic and electrokinetic properties, on the colloidal stability of PZQ nanosuspensions. The hydrophobic character of the drug, intensely determining the flocculation curves, was confirmed by the thermodynamic characterization. The electrophoretic characterization, in combination with the sedimentation and relative absorbance versus time curves, highlighted that the electrical double layer thickness and the surface charge can play an essential role in the stability of the pharmaceutical colloid. Finally, it was demonstrated that controlling the pH values and the incorporation of electrolytes can help in formulating PZQ aqueous nanosuspensions with appropriate stability and redispersibility behaviours for pharmaceutical use.
Fil: Martinez, Noelia Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Fernández Álvarez, Fátima. Universidad de Granada; España
Fil: Delgado, Ángel V.. Universidad de Granada; España
Fil: Badillo García, María Luisa. Universidad de Granada; España
Fil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Cerutti, Estela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Arias, José L.. Universidad de Granada; España
description Praziquantel (PZQ), a broad spectrum anthelmintic drug, cannot be found in acceptable dosage forms for elderly patients, paediatric patients, and for veterinary use. In fact, very little has been done up to now in the formulation of liquid dosage forms, being they always formulated for parenteral administration. To beat this important challenge, it was accomplished a comprehensive analysis of the influence of two elementary physicochemical aspects, i.e. surface thermodynamic and electrokinetic properties, on the colloidal stability of PZQ nanosuspensions. The hydrophobic character of the drug, intensely determining the flocculation curves, was confirmed by the thermodynamic characterization. The electrophoretic characterization, in combination with the sedimentation and relative absorbance versus time curves, highlighted that the electrical double layer thickness and the surface charge can play an essential role in the stability of the pharmaceutical colloid. Finally, it was demonstrated that controlling the pH values and the incorporation of electrolytes can help in formulating PZQ aqueous nanosuspensions with appropriate stability and redispersibility behaviours for pharmaceutical use.
publishDate 2020
dc.date.none.fl_str_mv 2020-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138054
Martinez, Noelia Anabel; Fernández Álvarez, Fátima; Delgado, Ángel V.; Badillo García, María Luisa; Raba, Julio; et al.; First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications; Taylor & Francis; Pharmaceutical Development and Technology; 25; 7; 8-2020; 892-898
1083-7450
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138054
identifier_str_mv Martinez, Noelia Anabel; Fernández Álvarez, Fátima; Delgado, Ángel V.; Badillo García, María Luisa; Raba, Julio; et al.; First steps in the formulation of praziquantel nanosuspensions for pharmaceutical applications; Taylor & Francis; Pharmaceutical Development and Technology; 25; 7; 8-2020; 892-898
1083-7450
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10837450.2020.1756320
info:eu-repo/semantics/altIdentifier/doi/10.1080/10837450.2020.1756320
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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