Nutritional status of pregnant mothers influence the health in adult life of their children
- Autores
- Echarte, Stella Maris; Abalo, Rocío Isabel; Chisari, Andrea Nancy
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk in developing metabolic diseases. Growth restriction in utero is associated with the development of obesity, hypertension, and diabetes. In these processes, the liver plays a fundamental role. The aim of this work was to evaluate the effects of a low protein diet in pregnant and lactating mothers on the antioxidant status of the offspring liver. To reproduce real conditions, we used an experimental rat model. Both ROS and the protective antioxidant systems have to work in coordination to reach a state of redox homeostasis. Excess generation of ROS may result in cell death or different pathological processes. The study also highlights the complex nature of malnutrition injury in which ROS correlates with the hepatic injury in a cause-and-effect manner. The male offspring with intrauterine growth restriction (IUGR) caused by the isocaloric low-protein diet (8%) showed decreased liver and body weight at birth. Hepatic cholesterol levels and serum transaminase increase, at weaning (24 day of age). We observed excess generation of ROS, carbonyl group and lipoperoxidation with that may result in cell death or different pathological processes in the liver. Conclusion: This study would suggests that liver injury due to accelerated release of toxic oxygen species and impaired antioxidant status may contribute to the high susceptibility to suffer metabolic diseases, that are related to diet in early life and that manifest in adulthood.
Fil: Echarte, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Abalo, Rocío Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina
Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina - Materia
-
FETAL PROGRAMMING
ESTRES OXIDATIVO
HÍGADO - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/116861
Ver los metadatos del registro completo
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Nutritional status of pregnant mothers influence the health in adult life of their childrenEcharte, Stella MarisAbalo, Rocío IsabelChisari, Andrea NancyFETAL PROGRAMMINGESTRES OXIDATIVOHÍGADOhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk in developing metabolic diseases. Growth restriction in utero is associated with the development of obesity, hypertension, and diabetes. In these processes, the liver plays a fundamental role. The aim of this work was to evaluate the effects of a low protein diet in pregnant and lactating mothers on the antioxidant status of the offspring liver. To reproduce real conditions, we used an experimental rat model. Both ROS and the protective antioxidant systems have to work in coordination to reach a state of redox homeostasis. Excess generation of ROS may result in cell death or different pathological processes. The study also highlights the complex nature of malnutrition injury in which ROS correlates with the hepatic injury in a cause-and-effect manner. The male offspring with intrauterine growth restriction (IUGR) caused by the isocaloric low-protein diet (8%) showed decreased liver and body weight at birth. Hepatic cholesterol levels and serum transaminase increase, at weaning (24 day of age). We observed excess generation of ROS, carbonyl group and lipoperoxidation with that may result in cell death or different pathological processes in the liver. Conclusion: This study would suggests that liver injury due to accelerated release of toxic oxygen species and impaired antioxidant status may contribute to the high susceptibility to suffer metabolic diseases, that are related to diet in early life and that manifest in adulthood.Fil: Echarte, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Abalo, Rocío Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaFil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; ArgentinaLifescience global2015-04-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/116861Echarte, Stella Maris; Abalo, Rocío Isabel; Chisari, Andrea Nancy; Nutritional status of pregnant mothers influence the health in adult life of their children; Lifescience global; Journal of Nutritional Therapeutics; 4; 1; 13-4-2015; 12-191929-5634CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.6000/1929-5634.2015.04.01.3info:eu-repo/semantics/altIdentifier/url/https://www.lifescienceglobal.com/journals/journal-of-nutritional-therapeutics/volume-4-number-1/87-abstract/jnt/1553-abstract-nutritional-status-of-pregnant-mothers-influence-the-health-in-adult-life-of-their-childreninfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:54Zoai:ri.conicet.gov.ar:11336/116861instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:54.696CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Nutritional status of pregnant mothers influence the health in adult life of their children |
title |
Nutritional status of pregnant mothers influence the health in adult life of their children |
spellingShingle |
Nutritional status of pregnant mothers influence the health in adult life of their children Echarte, Stella Maris FETAL PROGRAMMING ESTRES OXIDATIVO HÍGADO |
title_short |
Nutritional status of pregnant mothers influence the health in adult life of their children |
title_full |
Nutritional status of pregnant mothers influence the health in adult life of their children |
title_fullStr |
Nutritional status of pregnant mothers influence the health in adult life of their children |
title_full_unstemmed |
Nutritional status of pregnant mothers influence the health in adult life of their children |
title_sort |
Nutritional status of pregnant mothers influence the health in adult life of their children |
dc.creator.none.fl_str_mv |
Echarte, Stella Maris Abalo, Rocío Isabel Chisari, Andrea Nancy |
author |
Echarte, Stella Maris |
author_facet |
Echarte, Stella Maris Abalo, Rocío Isabel Chisari, Andrea Nancy |
author_role |
author |
author2 |
Abalo, Rocío Isabel Chisari, Andrea Nancy |
author2_role |
author author |
dc.subject.none.fl_str_mv |
FETAL PROGRAMMING ESTRES OXIDATIVO HÍGADO |
topic |
FETAL PROGRAMMING ESTRES OXIDATIVO HÍGADO |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk in developing metabolic diseases. Growth restriction in utero is associated with the development of obesity, hypertension, and diabetes. In these processes, the liver plays a fundamental role. The aim of this work was to evaluate the effects of a low protein diet in pregnant and lactating mothers on the antioxidant status of the offspring liver. To reproduce real conditions, we used an experimental rat model. Both ROS and the protective antioxidant systems have to work in coordination to reach a state of redox homeostasis. Excess generation of ROS may result in cell death or different pathological processes. The study also highlights the complex nature of malnutrition injury in which ROS correlates with the hepatic injury in a cause-and-effect manner. The male offspring with intrauterine growth restriction (IUGR) caused by the isocaloric low-protein diet (8%) showed decreased liver and body weight at birth. Hepatic cholesterol levels and serum transaminase increase, at weaning (24 day of age). We observed excess generation of ROS, carbonyl group and lipoperoxidation with that may result in cell death or different pathological processes in the liver. Conclusion: This study would suggests that liver injury due to accelerated release of toxic oxygen species and impaired antioxidant status may contribute to the high susceptibility to suffer metabolic diseases, that are related to diet in early life and that manifest in adulthood. Fil: Echarte, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina Fil: Abalo, Rocío Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina Fil: Chisari, Andrea Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina |
description |
Pregnancy and fetal development are periods of rapid growth and cell differentiation when mother and offspring are vulnerable to changes. Adverse events during development can be linked to an increased risk in developing metabolic diseases. Growth restriction in utero is associated with the development of obesity, hypertension, and diabetes. In these processes, the liver plays a fundamental role. The aim of this work was to evaluate the effects of a low protein diet in pregnant and lactating mothers on the antioxidant status of the offspring liver. To reproduce real conditions, we used an experimental rat model. Both ROS and the protective antioxidant systems have to work in coordination to reach a state of redox homeostasis. Excess generation of ROS may result in cell death or different pathological processes. The study also highlights the complex nature of malnutrition injury in which ROS correlates with the hepatic injury in a cause-and-effect manner. The male offspring with intrauterine growth restriction (IUGR) caused by the isocaloric low-protein diet (8%) showed decreased liver and body weight at birth. Hepatic cholesterol levels and serum transaminase increase, at weaning (24 day of age). We observed excess generation of ROS, carbonyl group and lipoperoxidation with that may result in cell death or different pathological processes in the liver. Conclusion: This study would suggests that liver injury due to accelerated release of toxic oxygen species and impaired antioxidant status may contribute to the high susceptibility to suffer metabolic diseases, that are related to diet in early life and that manifest in adulthood. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-13 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/116861 Echarte, Stella Maris; Abalo, Rocío Isabel; Chisari, Andrea Nancy; Nutritional status of pregnant mothers influence the health in adult life of their children; Lifescience global; Journal of Nutritional Therapeutics; 4; 1; 13-4-2015; 12-19 1929-5634 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/116861 |
identifier_str_mv |
Echarte, Stella Maris; Abalo, Rocío Isabel; Chisari, Andrea Nancy; Nutritional status of pregnant mothers influence the health in adult life of their children; Lifescience global; Journal of Nutritional Therapeutics; 4; 1; 13-4-2015; 12-19 1929-5634 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.6000/1929-5634.2015.04.01.3 info:eu-repo/semantics/altIdentifier/url/https://www.lifescienceglobal.com/journals/journal-of-nutritional-therapeutics/volume-4-number-1/87-abstract/jnt/1553-abstract-nutritional-status-of-pregnant-mothers-influence-the-health-in-adult-life-of-their-children |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Lifescience global |
publisher.none.fl_str_mv |
Lifescience global |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614343737475072 |
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13.070432 |