MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children

Autores
Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; Sancilio, Andrea; Barboza, Edgar; Caría, Adriana; Fernández Gago, Guadalupe; Egües Almeida, Rodrigo; Castro, Laura; Pozzolo, Cecilia; Martínez, María V.; Grimaldi Alva, Luciano; Rebec, Beatriz; Calvo, Mariel; Henrichsen, Julieta; Nocito, Celina; González, Mariela; Barbero, Guillermo; Ves Losada, Juan; Caballero, Mauricio Tomás; Zurankovas, Valeria; Raggio, Mirta; Schavlovsky, Graciela; Kobylarz, Alicia; Wimmenauer, Vera; Bugna, Jimena; Williams, John V.; Sastre, Gustavo; Flamenco, Edgardo; Rodríguez Pérez, Alberto; Ferrero, Fernando; Libster, Romina Paula; Grijalva, Carlos G.; Polack, Fernando Pedro
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.
Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; Argentina
Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; Argentina
Fil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; Argentina
Fil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; Argentina
Fil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Williams, John V.. Vanderbilt University; Estados Unidos
Fil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Grijalva, Carlos G.. Vanderbilt University; Estados Unidos
Fil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina
Materia
Respiratory Syncytial Virus
Bronchiolitis
Fetal Programming Hypothesis
Life-Threatening Illness
Carbohydrates
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/23250

id CONICETDig_03dc5121ba8dde0da0c4595a10f85f6a
oai_identifier_str oai:ri.conicet.gov.ar:11336/23250
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in childrenFerolla, Fausto MartínHijano, Diego RaúlAcosta, Patricio LeandroRodríguez, AndreaDueñas, KarinaSancilio, AndreaBarboza, EdgarCaría, AdrianaFernández Gago, GuadalupeEgües Almeida, RodrigoCastro, LauraPozzolo, CeciliaMartínez, María V.Grimaldi Alva, LucianoRebec, BeatrizCalvo, MarielHenrichsen, JulietaNocito, CelinaGonzález, MarielaBarbero, GuillermoVes Losada, JuanCaballero, Mauricio TomásZurankovas, ValeriaRaggio, MirtaSchavlovsky, GracielaKobylarz, AliciaWimmenauer, VeraBugna, JimenaWilliams, John V.Sastre, GustavoFlamenco, EdgardoRodríguez Pérez, AlbertoFerrero, FernandoLibster, Romina PaulaGrijalva, Carlos G.Polack, Fernando PedroRespiratory Syncytial VirusBronchiolitisFetal Programming HypothesisLife-Threatening IllnessCarbohydrateshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; ArgentinaFil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; ArgentinaFil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; ArgentinaFil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; ArgentinaFil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; ArgentinaFil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; ArgentinaFil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; ArgentinaFil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; ArgentinaFil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; ArgentinaFil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; ArgentinaFil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; ArgentinaFil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; ArgentinaFil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; ArgentinaFil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; ArgentinaFil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Williams, John V.. Vanderbilt University; Estados UnidosFil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; ArgentinaFil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; ArgentinaFil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Grijalva, Carlos G.. Vanderbilt University; Estados UnidosFil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; ArgentinaAmerican Thoracic Society2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23250Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-9901073-449XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201301-0016OCinfo:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/abs/10.1164/rccm.201301-0016OCinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:27Zoai:ri.conicet.gov.ar:11336/23250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:27.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
title MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
spellingShingle MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
Ferolla, Fausto Martín
Respiratory Syncytial Virus
Bronchiolitis
Fetal Programming Hypothesis
Life-Threatening Illness
Carbohydrates
title_short MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
title_full MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
title_fullStr MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
title_full_unstemmed MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
title_sort MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
dc.creator.none.fl_str_mv Ferolla, Fausto Martín
Hijano, Diego Raúl
Acosta, Patricio Leandro
Rodríguez, Andrea
Dueñas, Karina
Sancilio, Andrea
Barboza, Edgar
Caría, Adriana
Fernández Gago, Guadalupe
Egües Almeida, Rodrigo
Castro, Laura
Pozzolo, Cecilia
Martínez, María V.
Grimaldi Alva, Luciano
Rebec, Beatriz
Calvo, Mariel
Henrichsen, Julieta
Nocito, Celina
González, Mariela
Barbero, Guillermo
Ves Losada, Juan
Caballero, Mauricio Tomás
Zurankovas, Valeria
Raggio, Mirta
Schavlovsky, Graciela
Kobylarz, Alicia
Wimmenauer, Vera
Bugna, Jimena
Williams, John V.
Sastre, Gustavo
Flamenco, Edgardo
Rodríguez Pérez, Alberto
Ferrero, Fernando
Libster, Romina Paula
Grijalva, Carlos G.
Polack, Fernando Pedro
author Ferolla, Fausto Martín
author_facet Ferolla, Fausto Martín
Hijano, Diego Raúl
Acosta, Patricio Leandro
Rodríguez, Andrea
Dueñas, Karina
Sancilio, Andrea
Barboza, Edgar
Caría, Adriana
Fernández Gago, Guadalupe
Egües Almeida, Rodrigo
Castro, Laura
Pozzolo, Cecilia
Martínez, María V.
Grimaldi Alva, Luciano
Rebec, Beatriz
Calvo, Mariel
Henrichsen, Julieta
Nocito, Celina
González, Mariela
Barbero, Guillermo
Ves Losada, Juan
Caballero, Mauricio Tomás
Zurankovas, Valeria
Raggio, Mirta
Schavlovsky, Graciela
Kobylarz, Alicia
Wimmenauer, Vera
Bugna, Jimena
Williams, John V.
Sastre, Gustavo
Flamenco, Edgardo
Rodríguez Pérez, Alberto
Ferrero, Fernando
Libster, Romina Paula
Grijalva, Carlos G.
Polack, Fernando Pedro
author_role author
author2 Hijano, Diego Raúl
Acosta, Patricio Leandro
Rodríguez, Andrea
Dueñas, Karina
Sancilio, Andrea
Barboza, Edgar
Caría, Adriana
Fernández Gago, Guadalupe
Egües Almeida, Rodrigo
Castro, Laura
Pozzolo, Cecilia
Martínez, María V.
Grimaldi Alva, Luciano
Rebec, Beatriz
Calvo, Mariel
Henrichsen, Julieta
Nocito, Celina
González, Mariela
Barbero, Guillermo
Ves Losada, Juan
Caballero, Mauricio Tomás
Zurankovas, Valeria
Raggio, Mirta
Schavlovsky, Graciela
Kobylarz, Alicia
Wimmenauer, Vera
Bugna, Jimena
Williams, John V.
Sastre, Gustavo
Flamenco, Edgardo
Rodríguez Pérez, Alberto
Ferrero, Fernando
Libster, Romina Paula
Grijalva, Carlos G.
Polack, Fernando Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Respiratory Syncytial Virus
Bronchiolitis
Fetal Programming Hypothesis
Life-Threatening Illness
Carbohydrates
topic Respiratory Syncytial Virus
Bronchiolitis
Fetal Programming Hypothesis
Life-Threatening Illness
Carbohydrates
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.
Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; Argentina
Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; Argentina
Fil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; Argentina
Fil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; Argentina
Fil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Williams, John V.. Vanderbilt University; Estados Unidos
Fil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Grijalva, Carlos G.. Vanderbilt University; Estados Unidos
Fil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina
description Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/23250
Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-990
1073-449X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/23250
identifier_str_mv Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-990
1073-449X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201301-0016OC
info:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/abs/10.1164/rccm.201301-0016OC
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Thoracic Society
publisher.none.fl_str_mv American Thoracic Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614253441449984
score 13.070432