MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children
- Autores
- Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; Sancilio, Andrea; Barboza, Edgar; Caría, Adriana; Fernández Gago, Guadalupe; Egües Almeida, Rodrigo; Castro, Laura; Pozzolo, Cecilia; Martínez, María V.; Grimaldi Alva, Luciano; Rebec, Beatriz; Calvo, Mariel; Henrichsen, Julieta; Nocito, Celina; González, Mariela; Barbero, Guillermo; Ves Losada, Juan; Caballero, Mauricio Tomás; Zurankovas, Valeria; Raggio, Mirta; Schavlovsky, Graciela; Kobylarz, Alicia; Wimmenauer, Vera; Bugna, Jimena; Williams, John V.; Sastre, Gustavo; Flamenco, Edgardo; Rodríguez Pérez, Alberto; Ferrero, Fernando; Libster, Romina Paula; Grijalva, Carlos G.; Polack, Fernando Pedro
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.
Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; Argentina
Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina
Fil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina
Fil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina
Fil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; Argentina
Fil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; Argentina
Fil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina
Fil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina
Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; Argentina
Fil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Williams, John V.. Vanderbilt University; Estados Unidos
Fil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina
Fil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina
Fil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina
Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina
Fil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina
Fil: Grijalva, Carlos G.. Vanderbilt University; Estados Unidos
Fil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina - Materia
-
Respiratory Syncytial Virus
Bronchiolitis
Fetal Programming Hypothesis
Life-Threatening Illness
Carbohydrates - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/23250
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oai:ri.conicet.gov.ar:11336/23250 |
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CONICET Digital (CONICET) |
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MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in childrenFerolla, Fausto MartínHijano, Diego RaúlAcosta, Patricio LeandroRodríguez, AndreaDueñas, KarinaSancilio, AndreaBarboza, EdgarCaría, AdrianaFernández Gago, GuadalupeEgües Almeida, RodrigoCastro, LauraPozzolo, CeciliaMartínez, María V.Grimaldi Alva, LucianoRebec, BeatrizCalvo, MarielHenrichsen, JulietaNocito, CelinaGonzález, MarielaBarbero, GuillermoVes Losada, JuanCaballero, Mauricio TomásZurankovas, ValeriaRaggio, MirtaSchavlovsky, GracielaKobylarz, AliciaWimmenauer, VeraBugna, JimenaWilliams, John V.Sastre, GustavoFlamenco, EdgardoRodríguez Pérez, AlbertoFerrero, FernandoLibster, Romina PaulaGrijalva, Carlos G.Polack, Fernando PedroRespiratory Syncytial VirusBronchiolitisFetal Programming HypothesisLife-Threatening IllnessCarbohydrateshttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes.Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; ArgentinaFil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; ArgentinaFil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; ArgentinaFil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; ArgentinaFil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; ArgentinaFil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; ArgentinaFil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; ArgentinaFil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; ArgentinaFil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; ArgentinaFil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; ArgentinaFil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; ArgentinaFil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; ArgentinaFil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; ArgentinaFil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; ArgentinaFil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Williams, John V.. Vanderbilt University; Estados UnidosFil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; ArgentinaFil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; ArgentinaFil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Grijalva, Carlos G.. Vanderbilt University; Estados UnidosFil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; ArgentinaAmerican Thoracic Society2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/23250Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-9901073-449XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201301-0016OCinfo:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/abs/10.1164/rccm.201301-0016OCinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:27Zoai:ri.conicet.gov.ar:11336/23250instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:27.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
title |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
spellingShingle |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children Ferolla, Fausto Martín Respiratory Syncytial Virus Bronchiolitis Fetal Programming Hypothesis Life-Threatening Illness Carbohydrates |
title_short |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
title_full |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
title_fullStr |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
title_full_unstemmed |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
title_sort |
MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children |
dc.creator.none.fl_str_mv |
Ferolla, Fausto Martín Hijano, Diego Raúl Acosta, Patricio Leandro Rodríguez, Andrea Dueñas, Karina Sancilio, Andrea Barboza, Edgar Caría, Adriana Fernández Gago, Guadalupe Egües Almeida, Rodrigo Castro, Laura Pozzolo, Cecilia Martínez, María V. Grimaldi Alva, Luciano Rebec, Beatriz Calvo, Mariel Henrichsen, Julieta Nocito, Celina González, Mariela Barbero, Guillermo Ves Losada, Juan Caballero, Mauricio Tomás Zurankovas, Valeria Raggio, Mirta Schavlovsky, Graciela Kobylarz, Alicia Wimmenauer, Vera Bugna, Jimena Williams, John V. Sastre, Gustavo Flamenco, Edgardo Rodríguez Pérez, Alberto Ferrero, Fernando Libster, Romina Paula Grijalva, Carlos G. Polack, Fernando Pedro |
author |
Ferolla, Fausto Martín |
author_facet |
Ferolla, Fausto Martín Hijano, Diego Raúl Acosta, Patricio Leandro Rodríguez, Andrea Dueñas, Karina Sancilio, Andrea Barboza, Edgar Caría, Adriana Fernández Gago, Guadalupe Egües Almeida, Rodrigo Castro, Laura Pozzolo, Cecilia Martínez, María V. Grimaldi Alva, Luciano Rebec, Beatriz Calvo, Mariel Henrichsen, Julieta Nocito, Celina González, Mariela Barbero, Guillermo Ves Losada, Juan Caballero, Mauricio Tomás Zurankovas, Valeria Raggio, Mirta Schavlovsky, Graciela Kobylarz, Alicia Wimmenauer, Vera Bugna, Jimena Williams, John V. Sastre, Gustavo Flamenco, Edgardo Rodríguez Pérez, Alberto Ferrero, Fernando Libster, Romina Paula Grijalva, Carlos G. Polack, Fernando Pedro |
author_role |
author |
author2 |
Hijano, Diego Raúl Acosta, Patricio Leandro Rodríguez, Andrea Dueñas, Karina Sancilio, Andrea Barboza, Edgar Caría, Adriana Fernández Gago, Guadalupe Egües Almeida, Rodrigo Castro, Laura Pozzolo, Cecilia Martínez, María V. Grimaldi Alva, Luciano Rebec, Beatriz Calvo, Mariel Henrichsen, Julieta Nocito, Celina González, Mariela Barbero, Guillermo Ves Losada, Juan Caballero, Mauricio Tomás Zurankovas, Valeria Raggio, Mirta Schavlovsky, Graciela Kobylarz, Alicia Wimmenauer, Vera Bugna, Jimena Williams, John V. Sastre, Gustavo Flamenco, Edgardo Rodríguez Pérez, Alberto Ferrero, Fernando Libster, Romina Paula Grijalva, Carlos G. Polack, Fernando Pedro |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Respiratory Syncytial Virus Bronchiolitis Fetal Programming Hypothesis Life-Threatening Illness Carbohydrates |
topic |
Respiratory Syncytial Virus Bronchiolitis Fetal Programming Hypothesis Life-Threatening Illness Carbohydrates |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes. Fil: Ferolla, Fausto Martín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Hijano, Diego Raúl. Fundación para la Investigación en Infectologia Infantil; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Acosta, Patricio Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Rodríguez, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos Descentralizado “Evita Pueblo"; Argentina Fil: Dueñas, Karina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Sancilio, Andrea. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Barboza, Edgar. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina Fil: Caría, Adriana. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Narciso López"; Argentina Fil: Fernández Gago, Guadalupe. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina Fil: Egües Almeida, Rodrigo. Provincia de Buenos Aires. Ministerio de Salud. Hospital de Niños "Sor María Ludovica" de la Plata; Argentina Fil: Castro, Laura. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina Fil: Pozzolo, Cecilia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina Fil: Martínez, María V.. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina Fil: Grimaldi Alva, Luciano. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Lucio Meléndez”; Argentina Fil: Rebec, Beatriz. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón”; Argentina Fil: Calvo, Mariel. Provinicia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Presidente Perón"; Argentina Fil: Henrichsen, Julieta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina Fil: Nocito, Celina. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal General de Agudos “Dr. Pedro Fiorito”; Argentina Fil: González, Mariela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina Fil: Barbero, Guillermo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina Fil: Ves Losada, Juan. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; Argentina Fil: Caballero, Mauricio Tomás. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Zurankovas, Valeria. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Raggio, Mirta. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Schavlovsky, Graciela. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Kobylarz, Alicia. Provincia de Buenos Aires. Ministerio de Salud. Hospital Materno Infantil “Ana Goitia”; Argentina Fil: Wimmenauer, Vera. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Bugna, Jimena. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Williams, John V.. Vanderbilt University; Estados Unidos Fil: Sastre, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; Argentina Fil: Flamenco, Edgardo. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal de Agudos "Dr. Arturo Oñativia"; Argentina Fil: Rodríguez Pérez, Alberto. Provincia de Buenos Aires. Ministerio de Salud. Hospital Zonal General de Agudos “Dr. Alberto Eurnekián"; Argentina Fil: Ferrero, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina Fil: Libster, Romina Paula. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina Fil: Grijalva, Carlos G.. Vanderbilt University; Estados Unidos Fil: Polack, Fernando Pedro. Vanderbilt University; Estados Unidos. Fundación para la Investigación en Infectología Infantil; Argentina |
description |
Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O2 saturation [O2 sat] ≤ 87%) and fatal RSV infection, and characterized risk factors for life-threatening disease in hospitalized children. Special emphasis was placed on studying the impact of dietary habits during pregnancy. We hypothesized that dietary preferences, differing from those of our remote ancestors, would negatively impact children’s pulmonary health. For instance, a diet rich in carbohydrates is a signature of recent millennia and typical of low-income populations, heavily burdened by life-threatening RSV disease. Methods: Prospective study in a catchment population of 56,560 children under 2 years of age during the RSV season in Argentina. All children with respiratory signs and O2 sat less than 93% on admission were included. Measurements and Main Results: Among 1,293 children with respiratory infections, 797(61.6%) were infected with RSV: 106 of these had life-threatening disease; 1.9 per 1,000 children (95% confidence interval [CI], 1.5–2.2/1,000) under 24 months. A total of 22 hospitalized children died (9 RSV+), 26 died at home due to acute respiratory infection (14 attributed to RSV); all were under 12 months old. The annual attributable mortality rate for RSV was 0.7 per 1,000 infants (95% CI, 0.4–1.1/1,000). Life-threatening disease was dose-dependently associated with carbohydrate ingestion during pregnancy (adjusted odds ratio from 3.29 [95% CI, 1.15–9.44] to 7.36 [95% CI, 2.41–22.5] versus the lowest quartile). Conclusions: Life-threatening and fatal RSV infections are a heavy burden on infants in the developing world. Diets rich in carbohydrates during pregnancy are associated with these severe outcomes. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/23250 Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-990 1073-449X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/23250 |
identifier_str_mv |
Ferolla, Fausto Martín; Hijano, Diego Raúl; Acosta, Patricio Leandro; Rodríguez, Andrea; Dueñas, Karina; et al.; MAcronutrients during pregnancy and life-threatening respiratory syncytial virus infections in children; American Thoracic Society; American Journal of Respiratory and Critical Care Medicine; 187; 9; 3-2013; 983-990 1073-449X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1164/rccm.201301-0016OC info:eu-repo/semantics/altIdentifier/url/http://www.atsjournals.org/doi/abs/10.1164/rccm.201301-0016OC |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Thoracic Society |
publisher.none.fl_str_mv |
American Thoracic Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614253441449984 |
score |
13.070432 |