A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age

Autores
Mansilla, Eduardo; Roque, Gustavo; Sosa, Yolanda Elena; Tarditti, Adrian; Goya, Rodolfo Gustavo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
AbstractThere is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values.
Fil: Mansilla, Eduardo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Roque, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Sosa, Yolanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Tarditti, Adrian. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Materia
mesenchymal stem cells
female rats
longevity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48858
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of AgeMansilla, EduardoRoque, GustavoSosa, Yolanda ElenaTarditti, AdrianGoya, Rodolfo Gustavomesenchymal stem cellsfemale ratslongevityhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1AbstractThere is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values.Fil: Mansilla, Eduardo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; ArgentinaFil: Roque, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; ArgentinaFil: Sosa, Yolanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaFil: Tarditti, Adrian. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; ArgentinaFil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; ArgentinaMary Ann Liebert2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48858Mansilla, Eduardo; Roque, Gustavo; Sosa, Yolanda Elena; Tarditti, Adrian; Goya, Rodolfo Gustavo; A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age; Mary Ann Liebert; Rejuvenation Research; 19; 4; 8-2016; 318-3211549-1684CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/rej.2015.1777info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/abs/10.1089/rej.2015.1777info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971423/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-03-31T15:02:32Zoai:ri.conicet.gov.ar:11336/48858instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-03-31 15:02:32.737CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
title A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
spellingShingle A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
Mansilla, Eduardo
mesenchymal stem cells
female rats
longevity
title_short A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
title_full A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
title_fullStr A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
title_full_unstemmed A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
title_sort A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age
dc.creator.none.fl_str_mv Mansilla, Eduardo
Roque, Gustavo
Sosa, Yolanda Elena
Tarditti, Adrian
Goya, Rodolfo Gustavo
author Mansilla, Eduardo
author_facet Mansilla, Eduardo
Roque, Gustavo
Sosa, Yolanda Elena
Tarditti, Adrian
Goya, Rodolfo Gustavo
author_role author
author2 Roque, Gustavo
Sosa, Yolanda Elena
Tarditti, Adrian
Goya, Rodolfo Gustavo
author2_role author
author
author
author
dc.subject.none.fl_str_mv mesenchymal stem cells
female rats
longevity
topic mesenchymal stem cells
female rats
longevity
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv AbstractThere is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values.
Fil: Mansilla, Eduardo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Roque, Gustavo. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Sosa, Yolanda Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
Fil: Tarditti, Adrian. Provincia de Buenos Aires. Ministerio de Salud. Centro Único Coordinador de Ablación e Implante Provincia de Buenos Aires; Argentina
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
description AbstractThere is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and the cells were administered every 2 weeks afterward. The treatment did not induce any obvious changes in body growth or behavior and the rat showed the typical age changes for this strain, except that, unlike intact counterparts, the animal did not develop mammary tumors or pituitary gland hyperplasia. The more remarkable effect of the treatment was on life span, which was 44 months compared with an average of 36 months for intact laboratory rats. We conclude that despite the low N value, it is likely that the MSC treatment was responsible for the exceptionally long survival of the rat. The potential rewards of confirming the present findings warrant further studies involving higher N values.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48858
Mansilla, Eduardo; Roque, Gustavo; Sosa, Yolanda Elena; Tarditti, Adrian; Goya, Rodolfo Gustavo; A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age; Mary Ann Liebert; Rejuvenation Research; 19; 4; 8-2016; 318-321
1549-1684
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48858
identifier_str_mv Mansilla, Eduardo; Roque, Gustavo; Sosa, Yolanda Elena; Tarditti, Adrian; Goya, Rodolfo Gustavo; A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age; Mary Ann Liebert; Rejuvenation Research; 19; 4; 8-2016; 318-321
1549-1684
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/rej.2015.1777
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/abs/10.1089/rej.2015.1777
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971423/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.822162

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