Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study

Autores
Zeni, Susana Noemi; Soler, Carlos R. Ortela; Lazzari, Araceli; Lopez, Laura Beatriz; Suarez, Marisa; Di Gregorio, Silvana; Somoza, Julia Isabel; Pita Martín de Portela, María Luz
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This longitudinal study evaluated bone turnover and the interrelationship between changes in bone biomarkers and habitual dietary calcium intake during pregnancy in a group of women ranging widely with regard to dietary calcium intake. Thirty-nine healthy pregnant and 30 nonpregnant women were studied. Calcium, phosphorus, 1α,25-dihydroxyvitamin D (1,25diHOD), bone alkaline phosphatase (bALP), carboxyterminal propeptides of type I procollagen (PICP) and carboxyterminal telopeptides of type I collagen (βCTX and ICTP) were measured in serum and calcium, and creatinine and aminoterminal telopeptide (NTX) were determined in urine. Serum calcium and phosphorus did not change but the urinary Ca/Creat ratio and 1,25diHOD increased throughout pregnancy (P < 0.001 and P < 0.0001, respectively). Serum b-ALP and PICP increased during the last two trimesters (P < 0.0001 and P < 0.001, respectively). All studied bone resorption markers increased compared to nonpregnant values throughout pregnancy. The highest increment was observed in the third trimester. The level of significance decreased as follows: βCTX > NTX >ICTP. Serum 1,25 diHOD versus calcium intake showed a positive and significant correlation (r = 0.51, P < 0.02). A negative correlation between the absolute change in βCTX, NTX, and b-ALP between the third and second trimester and calcium intake at the end of pregnancy was observed in pregnant women who did not cover adequately calcium intake requirements (r = -0.47, P < 0.03; r = -0.41, P < 0.05; and r = -0.43, P < 0.05, respectively). These results suggest that skeletal response to pregnancy may not be entirely independent of maternal calcium intake, especially in women with usually low calcium intake. In summary, not only hormonal changes in calcium metabolism that occur during pregnancy but also other considerations, such as low dietary calcium intake, may lead to an increment in the biological activity of the skeleton. Additional studies must be conducted to confirm our findings and to gain a better understanding of skeletal response to a low calcium intake during pregnancy.
Fil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Soler, Carlos R. Ortela. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Lazzari, Araceli. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Lopez, Laura Beatriz. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Suarez, Marisa. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Di Gregorio, Silvana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Pita Martín de Portela, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Sanidad Nutricion Bromatologia y Toxicologia. Catedra de Nutricion.; Argentina
Materia
BONE TURNOVER MARKERS
CUSTOMARY LOW CALCIUM INTAKE
PREGNANCY
WOMEN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/123208
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal studyZeni, Susana NoemiSoler, Carlos R. OrtelaLazzari, AraceliLopez, Laura BeatrizSuarez, MarisaDi Gregorio, SilvanaSomoza, Julia IsabelPita Martín de Portela, María LuzBONE TURNOVER MARKERSCUSTOMARY LOW CALCIUM INTAKEPREGNANCYWOMENhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3This longitudinal study evaluated bone turnover and the interrelationship between changes in bone biomarkers and habitual dietary calcium intake during pregnancy in a group of women ranging widely with regard to dietary calcium intake. Thirty-nine healthy pregnant and 30 nonpregnant women were studied. Calcium, phosphorus, 1α,25-dihydroxyvitamin D (1,25diHOD), bone alkaline phosphatase (bALP), carboxyterminal propeptides of type I procollagen (PICP) and carboxyterminal telopeptides of type I collagen (βCTX and ICTP) were measured in serum and calcium, and creatinine and aminoterminal telopeptide (NTX) were determined in urine. Serum calcium and phosphorus did not change but the urinary Ca/Creat ratio and 1,25diHOD increased throughout pregnancy (P < 0.001 and P < 0.0001, respectively). Serum b-ALP and PICP increased during the last two trimesters (P < 0.0001 and P < 0.001, respectively). All studied bone resorption markers increased compared to nonpregnant values throughout pregnancy. The highest increment was observed in the third trimester. The level of significance decreased as follows: βCTX > NTX >ICTP. Serum 1,25 diHOD versus calcium intake showed a positive and significant correlation (r = 0.51, P < 0.02). A negative correlation between the absolute change in βCTX, NTX, and b-ALP between the third and second trimester and calcium intake at the end of pregnancy was observed in pregnant women who did not cover adequately calcium intake requirements (r = -0.47, P < 0.03; r = -0.41, P < 0.05; and r = -0.43, P < 0.05, respectively). These results suggest that skeletal response to pregnancy may not be entirely independent of maternal calcium intake, especially in women with usually low calcium intake. In summary, not only hormonal changes in calcium metabolism that occur during pregnancy but also other considerations, such as low dietary calcium intake, may lead to an increment in the biological activity of the skeleton. Additional studies must be conducted to confirm our findings and to gain a better understanding of skeletal response to a low calcium intake during pregnancy.Fil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; ArgentinaFil: Soler, Carlos R. Ortela. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;Fil: Lazzari, Araceli. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;Fil: Lopez, Laura Beatriz. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;Fil: Suarez, Marisa. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;Fil: Di Gregorio, Silvana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; ArgentinaFil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; ArgentinaFil: Pita Martín de Portela, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Sanidad Nutricion Bromatologia y Toxicologia. Catedra de Nutricion.; ArgentinaElsevier Science Inc2003-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/123208Zeni, Susana Noemi; Soler, Carlos R. Ortela; Lazzari, Araceli; Lopez, Laura Beatriz; Suarez, Marisa; et al.; Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study; Elsevier Science Inc; Bone; 33; 4; 10-2003; 606-6138756-3282CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S8756-3282(03)00203-5info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S8756328203002035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:07Zoai:ri.conicet.gov.ar:11336/123208instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:07.198CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
title Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
spellingShingle Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
Zeni, Susana Noemi
BONE TURNOVER MARKERS
CUSTOMARY LOW CALCIUM INTAKE
PREGNANCY
WOMEN
title_short Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
title_full Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
title_fullStr Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
title_full_unstemmed Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
title_sort Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study
dc.creator.none.fl_str_mv Zeni, Susana Noemi
Soler, Carlos R. Ortela
Lazzari, Araceli
Lopez, Laura Beatriz
Suarez, Marisa
Di Gregorio, Silvana
Somoza, Julia Isabel
Pita Martín de Portela, María Luz
author Zeni, Susana Noemi
author_facet Zeni, Susana Noemi
Soler, Carlos R. Ortela
Lazzari, Araceli
Lopez, Laura Beatriz
Suarez, Marisa
Di Gregorio, Silvana
Somoza, Julia Isabel
Pita Martín de Portela, María Luz
author_role author
author2 Soler, Carlos R. Ortela
Lazzari, Araceli
Lopez, Laura Beatriz
Suarez, Marisa
Di Gregorio, Silvana
Somoza, Julia Isabel
Pita Martín de Portela, María Luz
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BONE TURNOVER MARKERS
CUSTOMARY LOW CALCIUM INTAKE
PREGNANCY
WOMEN
topic BONE TURNOVER MARKERS
CUSTOMARY LOW CALCIUM INTAKE
PREGNANCY
WOMEN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This longitudinal study evaluated bone turnover and the interrelationship between changes in bone biomarkers and habitual dietary calcium intake during pregnancy in a group of women ranging widely with regard to dietary calcium intake. Thirty-nine healthy pregnant and 30 nonpregnant women were studied. Calcium, phosphorus, 1α,25-dihydroxyvitamin D (1,25diHOD), bone alkaline phosphatase (bALP), carboxyterminal propeptides of type I procollagen (PICP) and carboxyterminal telopeptides of type I collagen (βCTX and ICTP) were measured in serum and calcium, and creatinine and aminoterminal telopeptide (NTX) were determined in urine. Serum calcium and phosphorus did not change but the urinary Ca/Creat ratio and 1,25diHOD increased throughout pregnancy (P < 0.001 and P < 0.0001, respectively). Serum b-ALP and PICP increased during the last two trimesters (P < 0.0001 and P < 0.001, respectively). All studied bone resorption markers increased compared to nonpregnant values throughout pregnancy. The highest increment was observed in the third trimester. The level of significance decreased as follows: βCTX > NTX >ICTP. Serum 1,25 diHOD versus calcium intake showed a positive and significant correlation (r = 0.51, P < 0.02). A negative correlation between the absolute change in βCTX, NTX, and b-ALP between the third and second trimester and calcium intake at the end of pregnancy was observed in pregnant women who did not cover adequately calcium intake requirements (r = -0.47, P < 0.03; r = -0.41, P < 0.05; and r = -0.43, P < 0.05, respectively). These results suggest that skeletal response to pregnancy may not be entirely independent of maternal calcium intake, especially in women with usually low calcium intake. In summary, not only hormonal changes in calcium metabolism that occur during pregnancy but also other considerations, such as low dietary calcium intake, may lead to an increment in the biological activity of the skeleton. Additional studies must be conducted to confirm our findings and to gain a better understanding of skeletal response to a low calcium intake during pregnancy.
Fil: Zeni, Susana Noemi. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
Fil: Soler, Carlos R. Ortela. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Lazzari, Araceli. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Lopez, Laura Beatriz. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Suarez, Marisa. Hospital Interzonal General de Agudos Paroissien (higa Paroissien) ; Gobierno de la Provincia de Buenos Aires;
Fil: Di Gregorio, Silvana. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Somoza, Julia Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. División Osteopatías; Argentina
Fil: Pita Martín de Portela, María Luz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Sanidad Nutricion Bromatologia y Toxicologia. Catedra de Nutricion.; Argentina
description This longitudinal study evaluated bone turnover and the interrelationship between changes in bone biomarkers and habitual dietary calcium intake during pregnancy in a group of women ranging widely with regard to dietary calcium intake. Thirty-nine healthy pregnant and 30 nonpregnant women were studied. Calcium, phosphorus, 1α,25-dihydroxyvitamin D (1,25diHOD), bone alkaline phosphatase (bALP), carboxyterminal propeptides of type I procollagen (PICP) and carboxyterminal telopeptides of type I collagen (βCTX and ICTP) were measured in serum and calcium, and creatinine and aminoterminal telopeptide (NTX) were determined in urine. Serum calcium and phosphorus did not change but the urinary Ca/Creat ratio and 1,25diHOD increased throughout pregnancy (P < 0.001 and P < 0.0001, respectively). Serum b-ALP and PICP increased during the last two trimesters (P < 0.0001 and P < 0.001, respectively). All studied bone resorption markers increased compared to nonpregnant values throughout pregnancy. The highest increment was observed in the third trimester. The level of significance decreased as follows: βCTX > NTX >ICTP. Serum 1,25 diHOD versus calcium intake showed a positive and significant correlation (r = 0.51, P < 0.02). A negative correlation between the absolute change in βCTX, NTX, and b-ALP between the third and second trimester and calcium intake at the end of pregnancy was observed in pregnant women who did not cover adequately calcium intake requirements (r = -0.47, P < 0.03; r = -0.41, P < 0.05; and r = -0.43, P < 0.05, respectively). These results suggest that skeletal response to pregnancy may not be entirely independent of maternal calcium intake, especially in women with usually low calcium intake. In summary, not only hormonal changes in calcium metabolism that occur during pregnancy but also other considerations, such as low dietary calcium intake, may lead to an increment in the biological activity of the skeleton. Additional studies must be conducted to confirm our findings and to gain a better understanding of skeletal response to a low calcium intake during pregnancy.
publishDate 2003
dc.date.none.fl_str_mv 2003-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/123208
Zeni, Susana Noemi; Soler, Carlos R. Ortela; Lazzari, Araceli; Lopez, Laura Beatriz; Suarez, Marisa; et al.; Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study; Elsevier Science Inc; Bone; 33; 4; 10-2003; 606-613
8756-3282
CONICET Digital
CONICET
url http://hdl.handle.net/11336/123208
identifier_str_mv Zeni, Susana Noemi; Soler, Carlos R. Ortela; Lazzari, Araceli; Lopez, Laura Beatriz; Suarez, Marisa; et al.; Interrelationship between bone turnover markers and dietary calcium intake in pregnant women: A longitudinal study; Elsevier Science Inc; Bone; 33; 4; 10-2003; 606-613
8756-3282
CONICET Digital
CONICET
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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