Relation between probiotic milk administration and some bone turnover markers

Authors
Chaila, Zulema; Ortiz Zavalla, José; Alarcon, Oscar; Moreno, Roberto; Gusils Leon, Carlos Horacio; Gauffin Cano, María Paola; Oliver, Guillermo; Gonzalez, Silvia Nelina
Publication Year
2005
Language
English
Format
article
Status
Published version
Description
The evaluation of several biochemical markers can reflect the overall skeletal rate of bone turnover. Scarce information about the effects of probiotic foods on the calcium metabolism and bone turnover markers is available. A fermented milk containing probiotic lactobacilli, as a natural strategy to prevent or slow the bone loss process in perimenospausal women, was assayed. A randomized double-blind study with apparently healthy adult women was undertaken to assess whether an improvement of markers of bone turnover levels can be achieved after oral administration of lactobacilli. The results obtained from urinary Deoxypyridinoline levels on day 0 and day 35 indicated significant differences (p<0.05) between perimenopausal women receiving probiotic and those receiving placebo. The urinary type I collagen cross-linked N-telopeptide, did not showed significant differences (p<0.05) between day 0 and day 35 of women included in Test group. In each woman of Control group the relation calcium/creatinine did not show significant differences (p>0.05) between day 0 and day 35. The results obtained from two bone formation markers, serum osteocalcin and bone-specific alkaline phosphatase did not show significant differences (p>0.05). The results obtained in the present work could infer that the fermented milk consumption decreased the calcium loss in adult women.
Fil: Chaila, Zulema. Fundación ALAC; Argentina
Fil: Ortiz Zavalla, José. Centro Médico Humberto 1°; Argentina
Fil: Alarcon, Oscar. Centro Médico Humberto 1°; Argentina
Fil: Moreno, Roberto. Centro Médico Humberto 1°; Argentina
Fil: Gusils Leon, Carlos Horacio. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Oliver, Guillermo. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Gonzalez, Silvia Nelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentina
Subject
PROBIOTIC LACYTOBACILLI
BONE TURNOVER
PERIMENOPAUSAL WOMEN
Otras Ciencias Biológicas
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/56499