MIP-based decomposition strategies for large-scale scheduling problems in multiproduct multistage batch plants: A benchmark scheduling problem of the pharmaceutical industry

• Autores: Kopanos, Georgio M.; Mendez, Carlos Alberto; Puigjaner, Luis
• Año de publicación: 2010
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Scheduling; Large Scale Optimization; Mixed Integer Programming; Decomposition Strategy; Pharmaceutical Industry
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

An efficient systematic iterative solution strategy for solving real-world scheduling problems in multiproduct multistage batch plants is presented. Since the proposed method has its core a mathematical model, two alternative MIP scheduling formulations are suggested. The MIP-based solution strategy consists of a constructive step, wherein a feasible and initial solution is rapidly generated by following an iterative insertion procedure, and an improvement step, wherein the initial solution is systematically enhanced by implementing iteratively several rescheduling techniques, based on the mathematical model. A salient feature of our approach is that the scheduler can maintain the number of decisions at a reasonable level thus reducing appropriately the search space. A fact that usually results in manageable model sizes that often guarantees a more stable and predictable optimization model behavior. The proposed strategy performance is tested on several complicated problem instances of a multiproduct multistage pharmaceuticals scheduling problem. On average, high quality solutions are reported with relatively low computational effort. Authors encourage other researchers to adopt the large-scale pharmaceutical scheduling problem to test on it their solution techniques, and use it as a challenging comparison reference
Fil: Kopanos, Georgio M.. Universidad Politecnica de Catalunya; España
Fil: Mendez, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral; Argentina
Fil: Puigjaner, Luis. Universidad Politecnica de Catalunya; España