Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats

Autores
Fabio, Maria Carolina; Nizhnikov, Michael; Spear, Norman; Pautassi, Ricardo Marcos
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age range. Adolescent or adult rats were given 5, 2, or 0 ethanol exposures. The animals were tested for ethanol consumption through two-bottle choice tests, before undergoing a 1-week deprivation. A two-bottle assessment was conducted after the deprivation. Adolescents, but not adults, given two ethanol administrations during initiation exhibited significantly higher ethanol intake during the pre-deprivation period. These adolescents also exhibited a threefold increase in ethanol intake after 7 days of drug withdrawal, when compared with controls. These findings suggest that very brief experience with binge ethanol intoxication in adolescence, but not in adulthood, impacts later predisposition to drink.
Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Nizhnikov, Michael. University Of Binghamton; Estados Unidos
Fil: Spear, Norman. University Of Binghamton; Estados Unidos
Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Adolescent
Rat
Ethanol Initiation
Ethanol Intake
Light-Dark Test
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31640
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31640
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, ratsFabio, Maria CarolinaNizhnikov, MichaelSpear, NormanPautassi, Ricardo MarcosAdolescentRatEthanol InitiationEthanol IntakeLight-Dark Testhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age range. Adolescent or adult rats were given 5, 2, or 0 ethanol exposures. The animals were tested for ethanol consumption through two-bottle choice tests, before undergoing a 1-week deprivation. A two-bottle assessment was conducted after the deprivation. Adolescents, but not adults, given two ethanol administrations during initiation exhibited significantly higher ethanol intake during the pre-deprivation period. These adolescents also exhibited a threefold increase in ethanol intake after 7 days of drug withdrawal, when compared with controls. These findings suggest that very brief experience with binge ethanol intoxication in adolescence, but not in adulthood, impacts later predisposition to drink.Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaFil: Nizhnikov, Michael. University Of Binghamton; Estados UnidosFil: Spear, Norman. University Of Binghamton; Estados UnidosFil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaJohn Wiley & Sons Inc2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31640Fabio, Maria Carolina; Nizhnikov, Michael; Spear, Norman; Pautassi, Ricardo Marcos; Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats; John Wiley & Sons Inc; Developmental Psychobiology; 56; 3; 4-2014; 574-5830012-1630CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/dev.21101/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1002/dev.21101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:27:41Zoai:ri.conicet.gov.ar:11336/31640instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:27:41.236CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
title Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
spellingShingle Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
Fabio, Maria Carolina
Adolescent
Rat
Ethanol Initiation
Ethanol Intake
Light-Dark Test
title_short Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
title_full Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
title_fullStr Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
title_full_unstemmed Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
title_sort Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats
dc.creator.none.fl_str_mv Fabio, Maria Carolina
Nizhnikov, Michael
Spear, Norman
Pautassi, Ricardo Marcos
author Fabio, Maria Carolina
author_facet Fabio, Maria Carolina
Nizhnikov, Michael
Spear, Norman
Pautassi, Ricardo Marcos
author_role author
author2 Nizhnikov, Michael
Spear, Norman
Pautassi, Ricardo Marcos
author2_role author
author
author
dc.subject.none.fl_str_mv Adolescent
Rat
Ethanol Initiation
Ethanol Intake
Light-Dark Test
topic Adolescent
Rat
Ethanol Initiation
Ethanol Intake
Light-Dark Test
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age range. Adolescent or adult rats were given 5, 2, or 0 ethanol exposures. The animals were tested for ethanol consumption through two-bottle choice tests, before undergoing a 1-week deprivation. A two-bottle assessment was conducted after the deprivation. Adolescents, but not adults, given two ethanol administrations during initiation exhibited significantly higher ethanol intake during the pre-deprivation period. These adolescents also exhibited a threefold increase in ethanol intake after 7 days of drug withdrawal, when compared with controls. These findings suggest that very brief experience with binge ethanol intoxication in adolescence, but not in adulthood, impacts later predisposition to drink.
Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Fil: Nizhnikov, Michael. University Of Binghamton; Estados Unidos
Fil: Spear, Norman. University Of Binghamton; Estados Unidos
Fil: Pautassi, Ricardo Marcos. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description A question still to be answered is whether ethanol initiation has a greater effect on ethanol consumption if it occurs during adolescence than in adulthood. This study assessed the effect of ethanol initiation during adolescence or adulthood on voluntary ethanol consumption when animals were still within the same age range. Adolescent or adult rats were given 5, 2, or 0 ethanol exposures. The animals were tested for ethanol consumption through two-bottle choice tests, before undergoing a 1-week deprivation. A two-bottle assessment was conducted after the deprivation. Adolescents, but not adults, given two ethanol administrations during initiation exhibited significantly higher ethanol intake during the pre-deprivation period. These adolescents also exhibited a threefold increase in ethanol intake after 7 days of drug withdrawal, when compared with controls. These findings suggest that very brief experience with binge ethanol intoxication in adolescence, but not in adulthood, impacts later predisposition to drink.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31640
Fabio, Maria Carolina; Nizhnikov, Michael; Spear, Norman; Pautassi, Ricardo Marcos; Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats; John Wiley & Sons Inc; Developmental Psychobiology; 56; 3; 4-2014; 574-583
0012-1630
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31640
identifier_str_mv Fabio, Maria Carolina; Nizhnikov, Michael; Spear, Norman; Pautassi, Ricardo Marcos; Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats; John Wiley & Sons Inc; Developmental Psychobiology; 56; 3; 4-2014; 574-583
0012-1630
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/dev.21101/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1002/dev.21101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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