Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action

Autores
Carlini, Valeria Paola; Poretti, María Belén; Rask Andersen, Mathias; Chavan, Rohit A.; Ponzio, Marina Flavia; Sawant, Rahul S.; de Barioglio, Susana Rubiales; Schiöth, Helgi B.; de Cuneo, Marta Fiol
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on themRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Q2 acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor type 2 (TrKB), mitogen activated protein kinases (MAPK/ERK) and serotonin transporter (SERT). Animals treated with fluoxetine 10 mg/Kg/day for 28 days showed a significant decrease in the percentage of time spent in the novel object recognition test (p¡Ü0.005) and induced MAPK1/ERK2 down-regulation (p=0.005). Our results suggest that the effect on cognition could probably be explained by fluoxetine interference in the MAPK/ERK memory pathway. In contrast, chronic treatment with venlafaxine did not reduce MAPK1/ERK2 expression, suggesting that MAPK1/ERK2 down-regulation is not a common effect of all antidepressant drugs. Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance.
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Poretti, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rask Andersen, Mathias. Uppsala Universitet; Suecia
Fil: Chavan, Rohit A.. Uppsala Universitet; Suecia
Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Sawant, Rahul S.. Uppsala Universitet; Suecia
Fil: de Barioglio, Susana Rubiales. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Schiöth, Helgi B.. Uppsala Universitet; Suecia
Fil: de Cuneo, Marta Fiol. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
Materia
fluoxetine
venlafaxine
memory
MAPH/ERK
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269571
Acceder
id CONICETDig_91ab23eac4af07ae94707e37972fab2e
oai_identifier_str oai:ri.conicet.gov.ar:11336/269571
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of actionCarlini, Valeria PaolaPoretti, María BelénRask Andersen, MathiasChavan, Rohit A.Ponzio, Marina FlaviaSawant, Rahul S.de Barioglio, Susana RubialesSchiöth, Helgi B.de Cuneo, Marta FiolfluoxetinevenlafaxinememoryMAPH/ERKhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on themRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Q2 acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor type 2 (TrKB), mitogen activated protein kinases (MAPK/ERK) and serotonin transporter (SERT). Animals treated with fluoxetine 10 mg/Kg/day for 28 days showed a significant decrease in the percentage of time spent in the novel object recognition test (p¡Ü0.005) and induced MAPK1/ERK2 down-regulation (p=0.005). Our results suggest that the effect on cognition could probably be explained by fluoxetine interference in the MAPK/ERK memory pathway. In contrast, chronic treatment with venlafaxine did not reduce MAPK1/ERK2 expression, suggesting that MAPK1/ERK2 down-regulation is not a common effect of all antidepressant drugs. Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance.Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Poretti, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Rask Andersen, Mathias. Uppsala Universitet; SueciaFil: Chavan, Rohit A.. Uppsala Universitet; SueciaFil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Sawant, Rahul S.. Uppsala Universitet; SueciaFil: de Barioglio, Susana Rubiales. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; ArgentinaFil: Schiöth, Helgi B.. Uppsala Universitet; SueciaFil: de Cuneo, Marta Fiol. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; ArgentinaPergamon-Elsevier Science Ltd2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269571Carlini, Valeria Paola; Poretti, María Belén; Rask Andersen, Mathias; Chavan, Rohit A.; Ponzio, Marina Flavia; et al.; Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 38; 2; 8-2012; 159-1670278-5846CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2012.03.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:55:26Zoai:ri.conicet.gov.ar:11336/269571instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:55:26.868CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
title Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
spellingShingle Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
Carlini, Valeria Paola
fluoxetine
venlafaxine
memory
MAPH/ERK
title_short Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
title_full Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
title_fullStr Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
title_full_unstemmed Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
title_sort Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action
dc.creator.none.fl_str_mv Carlini, Valeria Paola
Poretti, María Belén
Rask Andersen, Mathias
Chavan, Rohit A.
Ponzio, Marina Flavia
Sawant, Rahul S.
de Barioglio, Susana Rubiales
Schiöth, Helgi B.
de Cuneo, Marta Fiol
author Carlini, Valeria Paola
author_facet Carlini, Valeria Paola
Poretti, María Belén
Rask Andersen, Mathias
Chavan, Rohit A.
Ponzio, Marina Flavia
Sawant, Rahul S.
de Barioglio, Susana Rubiales
Schiöth, Helgi B.
de Cuneo, Marta Fiol
author_role author
author2 Poretti, María Belén
Rask Andersen, Mathias
Chavan, Rohit A.
Ponzio, Marina Flavia
Sawant, Rahul S.
de Barioglio, Susana Rubiales
Schiöth, Helgi B.
de Cuneo, Marta Fiol
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv fluoxetine
venlafaxine
memory
MAPH/ERK
topic fluoxetine
venlafaxine
memory
MAPH/ERK
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on themRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Q2 acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor type 2 (TrKB), mitogen activated protein kinases (MAPK/ERK) and serotonin transporter (SERT). Animals treated with fluoxetine 10 mg/Kg/day for 28 days showed a significant decrease in the percentage of time spent in the novel object recognition test (p¡Ü0.005) and induced MAPK1/ERK2 down-regulation (p=0.005). Our results suggest that the effect on cognition could probably be explained by fluoxetine interference in the MAPK/ERK memory pathway. In contrast, chronic treatment with venlafaxine did not reduce MAPK1/ERK2 expression, suggesting that MAPK1/ERK2 down-regulation is not a common effect of all antidepressant drugs. Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance.
Fil: Carlini, Valeria Paola. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Poretti, María Belén. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Rask Andersen, Mathias. Uppsala Universitet; Suecia
Fil: Chavan, Rohit A.. Uppsala Universitet; Suecia
Fil: Ponzio, Marina Flavia. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Sawant, Rahul S.. Uppsala Universitet; Suecia
Fil: de Barioglio, Susana Rubiales. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacología; Argentina
Fil: Schiöth, Helgi B.. Uppsala Universitet; Suecia
Fil: de Cuneo, Marta Fiol. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Fisiología Humana y Física Biomédica. Cátedra de Fisiología Humana; Argentina
description Serotonin-specific reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are antidepressant drugs commonly used to treat a wide spectrum of mood disorders (Wong and Licinio, 2001). Although they have been clinically used for more than 50 years, the molecular and cellular basis for the action of SSRIs and SNRIs is not clear. Considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a SSRI (fluoxetine) and a SNRI (venlafaxine) on themRNA expression of genes related to memory cascade in the mouse hippocampus, namely, ¦Á-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Q2 acid (AMPA), nitric oxide synthase 1 (NOS1), neurotrophic tyrosine kinase receptor type 2 (TrKB), mitogen activated protein kinases (MAPK/ERK) and serotonin transporter (SERT). Animals treated with fluoxetine 10 mg/Kg/day for 28 days showed a significant decrease in the percentage of time spent in the novel object recognition test (p¡Ü0.005) and induced MAPK1/ERK2 down-regulation (p=0.005). Our results suggest that the effect on cognition could probably be explained by fluoxetine interference in the MAPK/ERK memory pathway. In contrast, chronic treatment with venlafaxine did not reduce MAPK1/ERK2 expression, suggesting that MAPK1/ERK2 down-regulation is not a common effect of all antidepressant drugs. Further studies are needed to examine the effect of chronic fluoxetine treatment on the ERK-CREB system, and to determine whether there is a causal relationship between the disruption of the ERK-CREB system and the effect of this antidepressant on memory performance.
publishDate 2012
dc.date.none.fl_str_mv 2012-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269571
Carlini, Valeria Paola; Poretti, María Belén; Rask Andersen, Mathias; Chavan, Rohit A.; Ponzio, Marina Flavia; et al.; Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 38; 2; 8-2012; 159-167
0278-5846
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269571
identifier_str_mv Carlini, Valeria Paola; Poretti, María Belén; Rask Andersen, Mathias; Chavan, Rohit A.; Ponzio, Marina Flavia; et al.; Differential effects of fluoxetine and venlafaxine on memory recognition: Possible mechanisms of action; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 38; 2; 8-2012; 159-167
0278-5846
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2012.03.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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