Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method

Autores
Bernardi, Larissa S.; Ferreira, Fábio F.; Cuffini, Silvia Lucia; Campos, Carlos E. M.; Monti, Gustavo Alberto; Kuminek, Gislaine; Oliveira, Paulo R.; Cardoso, Simone G.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs (Forms 1 and 2) and the polymorphic identification and quantification of four commercially-available VEN raw materials. These two polymorphic forms were obtained from different crystallization methods and characterized by X-ray Powder Diffraction (XRPD), Diffuse Reflectance Infrared Fourier Transform (DRIFT), Raman Spectroscopy (RS), liquid and solid state Nuclear Magnetic Resonance (NMR and ssNMR) spectroscopies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) techniques. The main differences were observed by DSC and XRPD and the latter was chosen as the standard technique for the identification and quantification studies in combination with the Rietveld method for the commercial raw materials (VEN1–VEN4) acquired from different manufacturers. Additionally Form 1 and Form 2 can be clearly distinguished from their 13C ssNMR spectra. Through the analysis, it was possible to conclude that VEN1 and VEN2 were composed only of Form 1, while VEN3 and VEN4 were a mixture of Forms 1 and 2. Additionally, the Rietveld refinement was successfully applied to quantify the polymorphic ratio for VEN3 and VEN4.
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
Fil: Ferreira, Fábio F.. Universidade Federal do ABC; Brasil
Fil: Cuffini, Silvia Lucia. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Campos, Carlos E. M.. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo R.. Universidade Estadual do Centro Oeste; Brasil
Fil: Cardoso, Simone G.. Universidade Federal de Santa Catarina; Brasil
Materia
Venlafaxine Hydrochloride
Polymorphism
X-Ray Powder Diffraction
Rietveld Method
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26037
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/26037
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld methodBernardi, Larissa S.Ferreira, Fábio F.Cuffini, Silvia LuciaCampos, Carlos E. M.Monti, Gustavo AlbertoKuminek, GislaineOliveira, Paulo R.Cardoso, Simone G.Venlafaxine HydrochloridePolymorphismX-Ray Powder DiffractionRietveld Methodhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs (Forms 1 and 2) and the polymorphic identification and quantification of four commercially-available VEN raw materials. These two polymorphic forms were obtained from different crystallization methods and characterized by X-ray Powder Diffraction (XRPD), Diffuse Reflectance Infrared Fourier Transform (DRIFT), Raman Spectroscopy (RS), liquid and solid state Nuclear Magnetic Resonance (NMR and ssNMR) spectroscopies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) techniques. The main differences were observed by DSC and XRPD and the latter was chosen as the standard technique for the identification and quantification studies in combination with the Rietveld method for the commercial raw materials (VEN1–VEN4) acquired from different manufacturers. Additionally Form 1 and Form 2 can be clearly distinguished from their 13C ssNMR spectra. Through the analysis, it was possible to conclude that VEN1 and VEN2 were composed only of Form 1, while VEN3 and VEN4 were a mixture of Forms 1 and 2. Additionally, the Rietveld refinement was successfully applied to quantify the polymorphic ratio for VEN3 and VEN4.Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; BrasilFil: Ferreira, Fábio F.. Universidade Federal do ABC; BrasilFil: Cuffini, Silvia Lucia. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Campos, Carlos E. M.. Universidade Federal de Santa Catarina; BrasilFil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; BrasilFil: Oliveira, Paulo R.. Universidade Estadual do Centro Oeste; BrasilFil: Cardoso, Simone G.. Universidade Federal de Santa Catarina; BrasilElsevier Science2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26037Bernardi, Larissa S.; Ferreira, Fábio F.; Cuffini, Silvia Lucia; Campos, Carlos E. M. ; Monti, Gustavo Alberto; et al.; Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method; Elsevier Science; Talanta; 117; 9-2013; 189-1950039-9140CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2013.09.006info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914013007340info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:39Zoai:ri.conicet.gov.ar:11336/26037instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:40.068CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
title Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
spellingShingle Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
Bernardi, Larissa S.
Venlafaxine Hydrochloride
Polymorphism
X-Ray Powder Diffraction
Rietveld Method
title_short Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
title_full Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
title_fullStr Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
title_full_unstemmed Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
title_sort Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method
dc.creator.none.fl_str_mv Bernardi, Larissa S.
Ferreira, Fábio F.
Cuffini, Silvia Lucia
Campos, Carlos E. M.
Monti, Gustavo Alberto
Kuminek, Gislaine
Oliveira, Paulo R.
Cardoso, Simone G.
author Bernardi, Larissa S.
author_facet Bernardi, Larissa S.
Ferreira, Fábio F.
Cuffini, Silvia Lucia
Campos, Carlos E. M.
Monti, Gustavo Alberto
Kuminek, Gislaine
Oliveira, Paulo R.
Cardoso, Simone G.
author_role author
author2 Ferreira, Fábio F.
Cuffini, Silvia Lucia
Campos, Carlos E. M.
Monti, Gustavo Alberto
Kuminek, Gislaine
Oliveira, Paulo R.
Cardoso, Simone G.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Venlafaxine Hydrochloride
Polymorphism
X-Ray Powder Diffraction
Rietveld Method
topic Venlafaxine Hydrochloride
Polymorphism
X-Ray Powder Diffraction
Rietveld Method
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs (Forms 1 and 2) and the polymorphic identification and quantification of four commercially-available VEN raw materials. These two polymorphic forms were obtained from different crystallization methods and characterized by X-ray Powder Diffraction (XRPD), Diffuse Reflectance Infrared Fourier Transform (DRIFT), Raman Spectroscopy (RS), liquid and solid state Nuclear Magnetic Resonance (NMR and ssNMR) spectroscopies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) techniques. The main differences were observed by DSC and XRPD and the latter was chosen as the standard technique for the identification and quantification studies in combination with the Rietveld method for the commercial raw materials (VEN1–VEN4) acquired from different manufacturers. Additionally Form 1 and Form 2 can be clearly distinguished from their 13C ssNMR spectra. Through the analysis, it was possible to conclude that VEN1 and VEN2 were composed only of Form 1, while VEN3 and VEN4 were a mixture of Forms 1 and 2. Additionally, the Rietveld refinement was successfully applied to quantify the polymorphic ratio for VEN3 and VEN4.
Fil: Bernardi, Larissa S.. Universidade Federal de Santa Catarina; Brasil
Fil: Ferreira, Fábio F.. Universidade Federal do ABC; Brasil
Fil: Cuffini, Silvia Lucia. Universidade Federal de Santa Catarina; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Campos, Carlos E. M.. Universidade Federal de Santa Catarina; Brasil
Fil: Monti, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Kuminek, Gislaine. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira, Paulo R.. Universidade Estadual do Centro Oeste; Brasil
Fil: Cardoso, Simone G.. Universidade Federal de Santa Catarina; Brasil
description Venlafaxine hydrochloride (VEN) is an antidepressant drug widely used for the treatment of depression. The purpose of this study was to carry out the preparation and solid state characterization of the pure polymorphs (Forms 1 and 2) and the polymorphic identification and quantification of four commercially-available VEN raw materials. These two polymorphic forms were obtained from different crystallization methods and characterized by X-ray Powder Diffraction (XRPD), Diffuse Reflectance Infrared Fourier Transform (DRIFT), Raman Spectroscopy (RS), liquid and solid state Nuclear Magnetic Resonance (NMR and ssNMR) spectroscopies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) techniques. The main differences were observed by DSC and XRPD and the latter was chosen as the standard technique for the identification and quantification studies in combination with the Rietveld method for the commercial raw materials (VEN1–VEN4) acquired from different manufacturers. Additionally Form 1 and Form 2 can be clearly distinguished from their 13C ssNMR spectra. Through the analysis, it was possible to conclude that VEN1 and VEN2 were composed only of Form 1, while VEN3 and VEN4 were a mixture of Forms 1 and 2. Additionally, the Rietveld refinement was successfully applied to quantify the polymorphic ratio for VEN3 and VEN4.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26037
Bernardi, Larissa S.; Ferreira, Fábio F.; Cuffini, Silvia Lucia; Campos, Carlos E. M. ; Monti, Gustavo Alberto; et al.; Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method; Elsevier Science; Talanta; 117; 9-2013; 189-195
0039-9140
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26037
identifier_str_mv Bernardi, Larissa S.; Ferreira, Fábio F.; Cuffini, Silvia Lucia; Campos, Carlos E. M. ; Monti, Gustavo Alberto; et al.; Solid-state evaluation and polymorphic quantification of venlafaxine hydrochloride raw materials using the Rietveld method; Elsevier Science; Talanta; 117; 9-2013; 189-195
0039-9140
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.talanta.2013.09.006
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914013007340
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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