Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP

Autores
Passafaro, Daniela; Reina, Silvia Lorena; Sterin, Leonor Josefina; Borda, Enri Santiago
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We demonstrate that patients with primary Sjögren’s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M3 muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial muscarinic agonist, increasing prostaglandin E2 (PGE2) and cyclic AMP production through modifying Na+/K+-ATPase activity, but also interfere with the secretory effect of the parasympathetic neurotransmitter. The IgG from patients with pSS has two effects on the submandibular gland. On the one hand, it may act as an inducer of the proinflammatory molecule (PGE2) that, in turn, inhibits Na+/K+-ATPase activity. On the other hand, it plays a role in the pathogenesis of dry mouth, abolishing the Na+/K+-ATPase inhibition and the net K+ efflux stimulation of the salivary gland in response to the authentic agonist pilocarpine, decreasing salivary fluid production.
Fil: Passafaro, Daniela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Submandibular Gland
Sodium Pump
Pge2
Cyclic Amp
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16269
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/16269
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMPPassafaro, DanielaReina, Silvia LorenaSterin, Leonor JosefinaBorda, Enri SantiagoSubmandibular GlandSodium PumpPge2Cyclic Amphttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3We demonstrate that patients with primary Sjögren’s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M3 muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial muscarinic agonist, increasing prostaglandin E2 (PGE2) and cyclic AMP production through modifying Na+/K+-ATPase activity, but also interfere with the secretory effect of the parasympathetic neurotransmitter. The IgG from patients with pSS has two effects on the submandibular gland. On the one hand, it may act as an inducer of the proinflammatory molecule (PGE2) that, in turn, inhibits Na+/K+-ATPase activity. On the other hand, it plays a role in the pathogenesis of dry mouth, abolishing the Na+/K+-ATPase inhibition and the net K+ efflux stimulation of the salivary gland in response to the authentic agonist pilocarpine, decreasing salivary fluid production.Fil: Passafaro, Daniela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; ArgentinaFil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaWiley Blackwell Publishing, Inc2010-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16269Passafaro, Daniela; Reina, Silvia Lorena; Sterin, Leonor Josefina; Borda, Enri Santiago; Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP; Wiley Blackwell Publishing, Inc; European Journal Of Oral Sciences; 118; 2; 4-2010; 131-1380909-8836enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0722.2010.00716.x/fullinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0722.2010.00716.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:41Zoai:ri.conicet.gov.ar:11336/16269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:41.782CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
title Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
spellingShingle Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
Passafaro, Daniela
Submandibular Gland
Sodium Pump
Pge2
Cyclic Amp
title_short Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
title_full Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
title_fullStr Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
title_full_unstemmed Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
title_sort Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP
dc.creator.none.fl_str_mv Passafaro, Daniela
Reina, Silvia Lorena
Sterin, Leonor Josefina
Borda, Enri Santiago
author Passafaro, Daniela
author_facet Passafaro, Daniela
Reina, Silvia Lorena
Sterin, Leonor Josefina
Borda, Enri Santiago
author_role author
author2 Reina, Silvia Lorena
Sterin, Leonor Josefina
Borda, Enri Santiago
author2_role author
author
author
dc.subject.none.fl_str_mv Submandibular Gland
Sodium Pump
Pge2
Cyclic Amp
topic Submandibular Gland
Sodium Pump
Pge2
Cyclic Amp
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We demonstrate that patients with primary Sjögren’s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M3 muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial muscarinic agonist, increasing prostaglandin E2 (PGE2) and cyclic AMP production through modifying Na+/K+-ATPase activity, but also interfere with the secretory effect of the parasympathetic neurotransmitter. The IgG from patients with pSS has two effects on the submandibular gland. On the one hand, it may act as an inducer of the proinflammatory molecule (PGE2) that, in turn, inhibits Na+/K+-ATPase activity. On the other hand, it plays a role in the pathogenesis of dry mouth, abolishing the Na+/K+-ATPase inhibition and the net K+ efflux stimulation of the salivary gland in response to the authentic agonist pilocarpine, decreasing salivary fluid production.
Fil: Passafaro, Daniela. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina
Fil: Reina, Silvia Lorena. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sterin, Leonor Josefina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Borda, Enri Santiago. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description We demonstrate that patients with primary Sjögren’s syndrome (pSS) produce functional IgG autoantibodies that interact with the glandular M3 muscarinic acetylcholine receptors (mAChRs). These autoantibodies act as a partial muscarinic agonist, increasing prostaglandin E2 (PGE2) and cyclic AMP production through modifying Na+/K+-ATPase activity, but also interfere with the secretory effect of the parasympathetic neurotransmitter. The IgG from patients with pSS has two effects on the submandibular gland. On the one hand, it may act as an inducer of the proinflammatory molecule (PGE2) that, in turn, inhibits Na+/K+-ATPase activity. On the other hand, it plays a role in the pathogenesis of dry mouth, abolishing the Na+/K+-ATPase inhibition and the net K+ efflux stimulation of the salivary gland in response to the authentic agonist pilocarpine, decreasing salivary fluid production.
publishDate 2010
dc.date.none.fl_str_mv 2010-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16269
Passafaro, Daniela; Reina, Silvia Lorena; Sterin, Leonor Josefina; Borda, Enri Santiago; Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP; Wiley Blackwell Publishing, Inc; European Journal Of Oral Sciences; 118; 2; 4-2010; 131-138
0909-8836
url http://hdl.handle.net/11336/16269
identifier_str_mv Passafaro, Daniela; Reina, Silvia Lorena; Sterin, Leonor Josefina; Borda, Enri Santiago; Cholinergic autoantibodies from primary Sjögren’s syndrome modulate submandibular gland Na+/K+-ATPase activity via prostaglandin E2 and cyclic AMP; Wiley Blackwell Publishing, Inc; European Journal Of Oral Sciences; 118; 2; 4-2010; 131-138
0909-8836
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0722.2010.00716.x/full
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0722.2010.00716.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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