Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside
- Autores
- Rodriguez Granillo, Gaston Alfredo
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT). Although both CMR and gadolinium agents have been originally deemed innocuous, a number of concerns (though inconclusive and very rare) have been recently issued regarding safety issues, including DNA double-strand breaks related to CMR, and gadolinium-associated nephrogenic systemic fibrosis and deposition in the skin and certain brain structures. These concerns have to be considered in the context of non-negligible rates of claustrophobia, increasing rates of patients with implantable cardiac devices, and a number of logistic drawbacks compared with CTDE, such as higher costs, longer scanning times, and difficulties to scan patients with impaired breath-holding capabilities. Overall, these issues might encourage the role of CTDE as an alternative for DE-CMR in selected populations.
Fil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Cardiac Imaging
Dual Energy
Late Enhancement
Magnetic Resonance
Necrosis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/59163
Ver los metadatos del registro completo
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Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedsideRodriguez Granillo, Gaston AlfredoCardiac ImagingDual EnergyLate EnhancementMagnetic ResonanceNecrosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT). Although both CMR and gadolinium agents have been originally deemed innocuous, a number of concerns (though inconclusive and very rare) have been recently issued regarding safety issues, including DNA double-strand breaks related to CMR, and gadolinium-associated nephrogenic systemic fibrosis and deposition in the skin and certain brain structures. These concerns have to be considered in the context of non-negligible rates of claustrophobia, increasing rates of patients with implantable cardiac devices, and a number of logistic drawbacks compared with CTDE, such as higher costs, longer scanning times, and difficulties to scan patients with impaired breath-holding capabilities. Overall, these issues might encourage the role of CTDE as an alternative for DE-CMR in selected populations.Fil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAME Publishing Company2017-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59163Rodriguez Granillo, Gaston Alfredo; Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 7; 2; 4-2017; 159-1702223-36522223-3660CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21037/cdt.2017.03.16info:eu-repo/semantics/altIdentifier/url/http://cdt.amegroups.com/article/view/13973/14836info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:11:44Zoai:ri.conicet.gov.ar:11336/59163instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:11:44.561CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
title |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
spellingShingle |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside Rodriguez Granillo, Gaston Alfredo Cardiac Imaging Dual Energy Late Enhancement Magnetic Resonance Necrosis |
title_short |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
title_full |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
title_fullStr |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
title_full_unstemmed |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
title_sort |
Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside |
dc.creator.none.fl_str_mv |
Rodriguez Granillo, Gaston Alfredo |
author |
Rodriguez Granillo, Gaston Alfredo |
author_facet |
Rodriguez Granillo, Gaston Alfredo |
author_role |
author |
dc.subject.none.fl_str_mv |
Cardiac Imaging Dual Energy Late Enhancement Magnetic Resonance Necrosis |
topic |
Cardiac Imaging Dual Energy Late Enhancement Magnetic Resonance Necrosis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT). Although both CMR and gadolinium agents have been originally deemed innocuous, a number of concerns (though inconclusive and very rare) have been recently issued regarding safety issues, including DNA double-strand breaks related to CMR, and gadolinium-associated nephrogenic systemic fibrosis and deposition in the skin and certain brain structures. These concerns have to be considered in the context of non-negligible rates of claustrophobia, increasing rates of patients with implantable cardiac devices, and a number of logistic drawbacks compared with CTDE, such as higher costs, longer scanning times, and difficulties to scan patients with impaired breath-holding capabilities. Overall, these issues might encourage the role of CTDE as an alternative for DE-CMR in selected populations. Fil: Rodriguez Granillo, Gaston Alfredo. Diagnóstico Maipú; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
A large number of studies support the increasingly relevant prognostic value of the presence and extent of delayed enhancement (DE), a surrogate marker of fibrosis, in diverse etiologies. Gadolinium and iodinated based contrast agents share similar kinetics, thus leading to comparable myocardial characterization with cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) at both first-pass perfusion and DE imaging. We review the available evidence of DE imaging for the assessment of myocardial infarction (MI) using cardiac CT (CTDE), from animal to clinical studies, and from 16-slice CT to dual-energy CT systems (DECT). Although both CMR and gadolinium agents have been originally deemed innocuous, a number of concerns (though inconclusive and very rare) have been recently issued regarding safety issues, including DNA double-strand breaks related to CMR, and gadolinium-associated nephrogenic systemic fibrosis and deposition in the skin and certain brain structures. These concerns have to be considered in the context of non-negligible rates of claustrophobia, increasing rates of patients with implantable cardiac devices, and a number of logistic drawbacks compared with CTDE, such as higher costs, longer scanning times, and difficulties to scan patients with impaired breath-holding capabilities. Overall, these issues might encourage the role of CTDE as an alternative for DE-CMR in selected populations. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/59163 Rodriguez Granillo, Gaston Alfredo; Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 7; 2; 4-2017; 159-170 2223-3652 2223-3660 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/59163 |
identifier_str_mv |
Rodriguez Granillo, Gaston Alfredo; Delayed enhancement cardiac computed tomography for the assessment of myocardial infarction: From bench to bedside; AME Publishing Company; Cardiovascular Diagnosis and Therapy; 7; 2; 4-2017; 159-170 2223-3652 2223-3660 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.21037/cdt.2017.03.16 info:eu-repo/semantics/altIdentifier/url/http://cdt.amegroups.com/article/view/13973/14836 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
AME Publishing Company |
publisher.none.fl_str_mv |
AME Publishing Company |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.22299 |