Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients

Autores
Rodriguez Granillo, Gaston Alfredo; Campisi, Roxana; Deviggiano, Alejandro; de Munain, Maria N. Lopez; De Zan, Macarena; Capunay, Carlos; Carrascosa, Patricia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
OBJECTIVE. The objective of our study was to explore whether delayed enhancement dual-energy CT (DECT) allows the detection of myocardial infarcts in stable patients. SUBJECTS AND METHODS. Patients with known or suspected coronary artery disease clinically referred for myocardial perfusion imaging using SPECT were prospectively included. All patients (n = 34) also underwent stress, rest, and delayed enhancement DECT on a DECT scanner. At SPECT, segments with myocardial infarction (MI) were defned as those with a summed rest score of = 2 in two or more consecutive segments, and a diagnosis of MI was supported by wall motion abnormalities, clinical history, and ECG fndings. RESULTS. Segments with MI were identifed in 13 (38%), 15 (44%), and 14 (41%) patients using SPECT, perfusion CT, and delayed enhancement DECT, respectively. When combined SPECT and perfusion CT results were used as the reference standard, delayed enhancement DECT had a sensitivity, specifcity, positive predictive value, and negative predictive value for the detection of MI of 91.7% (95% CI, 62-98%), 86.4% (95% CI, 65-97%), 78.6% (95% CI, 49-95%), and 95.0% (95% CI, 75-100%). At delayed enhancement DECT (40 keV), a signal attenuation higher than 161 HU had a sensitivity of 72% and a specifcity of 79% for the detection of MI on a per-segment basis. The median signal attenuation of myocardial infarcts at 40 keV was 3.0 SDs (interquartile range, 1.3-4.0 SDs) above that of normal myocardium. CONCLUSION. In this study, delayed enhancement DECT allowed the detection of myocardial infarcts in stable patients.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: de Munain, Maria N. Lopez. Diagnóstico Maipú; Argentina
Fil: De Zan, Macarena. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
Materia
Chronic Myocardial Infarction
Delayed Enhancement
Fibrosis
Late Enhancement
Spectral Imaging
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/59621
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/59621
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patientsRodriguez Granillo, Gaston AlfredoCampisi, RoxanaDeviggiano, Alejandrode Munain, Maria N. LopezDe Zan, MacarenaCapunay, CarlosCarrascosa, PatriciaChronic Myocardial InfarctionDelayed EnhancementFibrosisLate EnhancementSpectral Imaginghttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3OBJECTIVE. The objective of our study was to explore whether delayed enhancement dual-energy CT (DECT) allows the detection of myocardial infarcts in stable patients. SUBJECTS AND METHODS. Patients with known or suspected coronary artery disease clinically referred for myocardial perfusion imaging using SPECT were prospectively included. All patients (n = 34) also underwent stress, rest, and delayed enhancement DECT on a DECT scanner. At SPECT, segments with myocardial infarction (MI) were defned as those with a summed rest score of = 2 in two or more consecutive segments, and a diagnosis of MI was supported by wall motion abnormalities, clinical history, and ECG fndings. RESULTS. Segments with MI were identifed in 13 (38%), 15 (44%), and 14 (41%) patients using SPECT, perfusion CT, and delayed enhancement DECT, respectively. When combined SPECT and perfusion CT results were used as the reference standard, delayed enhancement DECT had a sensitivity, specifcity, positive predictive value, and negative predictive value for the detection of MI of 91.7% (95% CI, 62-98%), 86.4% (95% CI, 65-97%), 78.6% (95% CI, 49-95%), and 95.0% (95% CI, 75-100%). At delayed enhancement DECT (40 keV), a signal attenuation higher than 161 HU had a sensitivity of 72% and a specifcity of 79% for the detection of MI on a per-segment basis. The median signal attenuation of myocardial infarcts at 40 keV was 3.0 SDs (interquartile range, 1.3-4.0 SDs) above that of normal myocardium. CONCLUSION. In this study, delayed enhancement DECT allowed the detection of myocardial infarcts in stable patients.Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; ArgentinaFil: Campisi, Roxana. Diagnóstico Maipú; ArgentinaFil: Deviggiano, Alejandro. Diagnóstico Maipú; ArgentinaFil: de Munain, Maria N. Lopez. Diagnóstico Maipú; ArgentinaFil: De Zan, Macarena. Diagnóstico Maipú; ArgentinaFil: Capunay, Carlos. Diagnóstico Maipú; ArgentinaFil: Carrascosa, Patricia. Diagnóstico Maipú; ArgentinaAmerican Roentgen Ray Society2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/59621Rodriguez Granillo, Gaston Alfredo; Campisi, Roxana; Deviggiano, Alejandro; de Munain, Maria N. Lopez; De Zan, Macarena; et al.; Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients; American Roentgen Ray Society; American Journal of Roentgenology; 209; 5; 11-2017; 1023-10320361-803XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajronline.org/doi/10.2214/AJR.17.18118info:eu-repo/semantics/altIdentifier/doi/10.2214/AJR.17.18118info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:15Zoai:ri.conicet.gov.ar:11336/59621instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:15.387CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
title Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
spellingShingle Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
Rodriguez Granillo, Gaston Alfredo
Chronic Myocardial Infarction
Delayed Enhancement
Fibrosis
Late Enhancement
Spectral Imaging
title_short Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
title_full Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
title_fullStr Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
title_full_unstemmed Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
title_sort Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients
dc.creator.none.fl_str_mv Rodriguez Granillo, Gaston Alfredo
Campisi, Roxana
Deviggiano, Alejandro
de Munain, Maria N. Lopez
De Zan, Macarena
Capunay, Carlos
Carrascosa, Patricia
author Rodriguez Granillo, Gaston Alfredo
author_facet Rodriguez Granillo, Gaston Alfredo
Campisi, Roxana
Deviggiano, Alejandro
de Munain, Maria N. Lopez
De Zan, Macarena
Capunay, Carlos
Carrascosa, Patricia
author_role author
author2 Campisi, Roxana
Deviggiano, Alejandro
de Munain, Maria N. Lopez
De Zan, Macarena
Capunay, Carlos
Carrascosa, Patricia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chronic Myocardial Infarction
Delayed Enhancement
Fibrosis
Late Enhancement
Spectral Imaging
topic Chronic Myocardial Infarction
Delayed Enhancement
Fibrosis
Late Enhancement
Spectral Imaging
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv OBJECTIVE. The objective of our study was to explore whether delayed enhancement dual-energy CT (DECT) allows the detection of myocardial infarcts in stable patients. SUBJECTS AND METHODS. Patients with known or suspected coronary artery disease clinically referred for myocardial perfusion imaging using SPECT were prospectively included. All patients (n = 34) also underwent stress, rest, and delayed enhancement DECT on a DECT scanner. At SPECT, segments with myocardial infarction (MI) were defned as those with a summed rest score of = 2 in two or more consecutive segments, and a diagnosis of MI was supported by wall motion abnormalities, clinical history, and ECG fndings. RESULTS. Segments with MI were identifed in 13 (38%), 15 (44%), and 14 (41%) patients using SPECT, perfusion CT, and delayed enhancement DECT, respectively. When combined SPECT and perfusion CT results were used as the reference standard, delayed enhancement DECT had a sensitivity, specifcity, positive predictive value, and negative predictive value for the detection of MI of 91.7% (95% CI, 62-98%), 86.4% (95% CI, 65-97%), 78.6% (95% CI, 49-95%), and 95.0% (95% CI, 75-100%). At delayed enhancement DECT (40 keV), a signal attenuation higher than 161 HU had a sensitivity of 72% and a specifcity of 79% for the detection of MI on a per-segment basis. The median signal attenuation of myocardial infarcts at 40 keV was 3.0 SDs (interquartile range, 1.3-4.0 SDs) above that of normal myocardium. CONCLUSION. In this study, delayed enhancement DECT allowed the detection of myocardial infarcts in stable patients.
Fil: Rodriguez Granillo, Gaston Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Diagnóstico Maipú; Argentina
Fil: Campisi, Roxana. Diagnóstico Maipú; Argentina
Fil: Deviggiano, Alejandro. Diagnóstico Maipú; Argentina
Fil: de Munain, Maria N. Lopez. Diagnóstico Maipú; Argentina
Fil: De Zan, Macarena. Diagnóstico Maipú; Argentina
Fil: Capunay, Carlos. Diagnóstico Maipú; Argentina
Fil: Carrascosa, Patricia. Diagnóstico Maipú; Argentina
description OBJECTIVE. The objective of our study was to explore whether delayed enhancement dual-energy CT (DECT) allows the detection of myocardial infarcts in stable patients. SUBJECTS AND METHODS. Patients with known or suspected coronary artery disease clinically referred for myocardial perfusion imaging using SPECT were prospectively included. All patients (n = 34) also underwent stress, rest, and delayed enhancement DECT on a DECT scanner. At SPECT, segments with myocardial infarction (MI) were defned as those with a summed rest score of = 2 in two or more consecutive segments, and a diagnosis of MI was supported by wall motion abnormalities, clinical history, and ECG fndings. RESULTS. Segments with MI were identifed in 13 (38%), 15 (44%), and 14 (41%) patients using SPECT, perfusion CT, and delayed enhancement DECT, respectively. When combined SPECT and perfusion CT results were used as the reference standard, delayed enhancement DECT had a sensitivity, specifcity, positive predictive value, and negative predictive value for the detection of MI of 91.7% (95% CI, 62-98%), 86.4% (95% CI, 65-97%), 78.6% (95% CI, 49-95%), and 95.0% (95% CI, 75-100%). At delayed enhancement DECT (40 keV), a signal attenuation higher than 161 HU had a sensitivity of 72% and a specifcity of 79% for the detection of MI on a per-segment basis. The median signal attenuation of myocardial infarcts at 40 keV was 3.0 SDs (interquartile range, 1.3-4.0 SDs) above that of normal myocardium. CONCLUSION. In this study, delayed enhancement DECT allowed the detection of myocardial infarcts in stable patients.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/59621
Rodriguez Granillo, Gaston Alfredo; Campisi, Roxana; Deviggiano, Alejandro; de Munain, Maria N. Lopez; De Zan, Macarena; et al.; Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients; American Roentgen Ray Society; American Journal of Roentgenology; 209; 5; 11-2017; 1023-1032
0361-803X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/59621
identifier_str_mv Rodriguez Granillo, Gaston Alfredo; Campisi, Roxana; Deviggiano, Alejandro; de Munain, Maria N. Lopez; De Zan, Macarena; et al.; Detection of myocardial infarction using delayed enhancement dualenergy CT in stable patients; American Roentgen Ray Society; American Journal of Roentgenology; 209; 5; 11-2017; 1023-1032
0361-803X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ajronline.org/doi/10.2214/AJR.17.18118
info:eu-repo/semantics/altIdentifier/doi/10.2214/AJR.17.18118
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Roentgen Ray Society
publisher.none.fl_str_mv American Roentgen Ray Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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