Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas

Autores
Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; Losa, M.; Kuhlen, D.; Kreutzer, J.; Perone, Marcelo Javier; Arzt, Eduardo Simon; Stalla, G.K.; Renner, U.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.
Fil: Shan, B.. Max Planck Institute of Psychiatry; Alemania
Fil: Schaaf, C.. Max Planck Institute of Psychiatry; Alemania
Fil: Schmidt, A.. Max Planck Institute of Psychiatry; Alemania
Fil: Lucia, K.. Max Planck Institute of Psychiatry; Alemania
Fil: Buchfelder, M.. Universitat Erlangen-Nuremberg; Alemania
Fil: Losa, M.. Istituto San Raffael; Italia
Fil: Kuhlen, D.. Universitat Technical Zu Munich; Alemania
Fil: Kreutzer, J.. Universitat Technical Zu Munich; Alemania
Fil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina
Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina
Fil: Stalla, G.K.. Max Planck Institute of Psychiatry; Alemania
Fil: Renner, U.. Max Planck Institute of Psychiatry; Alemania
Materia
Pituitary
Adenoma
Curcumin
Angiogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/69079
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/69079
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomasShan, B.Schaaf, C.Schmidt, A.Lucia, K.Buchfelder, M.Losa, M.Kuhlen, D.Kreutzer, J.Perone, Marcelo JavierArzt, Eduardo SimonStalla, G.K.Renner, U.PituitaryAdenomaCurcuminAngiogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.Fil: Shan, B.. Max Planck Institute of Psychiatry; AlemaniaFil: Schaaf, C.. Max Planck Institute of Psychiatry; AlemaniaFil: Schmidt, A.. Max Planck Institute of Psychiatry; AlemaniaFil: Lucia, K.. Max Planck Institute of Psychiatry; AlemaniaFil: Buchfelder, M.. Universitat Erlangen-Nuremberg; AlemaniaFil: Losa, M.. Istituto San Raffael; ItaliaFil: Kuhlen, D.. Universitat Technical Zu Munich; AlemaniaFil: Kreutzer, J.. Universitat Technical Zu Munich; AlemaniaFil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; ArgentinaFil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; ArgentinaFil: Stalla, G.K.. Max Planck Institute of Psychiatry; AlemaniaFil: Renner, U.. Max Planck Institute of Psychiatry; AlemaniaBioScientifica2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/69079Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; et al.; Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas; BioScientifica; Journal of Endocrinology; 214; 3; 9-2012; 389-3980022-0795CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1530/JOE-12-0207info:eu-repo/semantics/altIdentifier/url/https://joe.bioscientifica.com/view/journals/joe/214/3/389.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:44Zoai:ri.conicet.gov.ar:11336/69079instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:45.074CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
title Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
spellingShingle Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
Shan, B.
Pituitary
Adenoma
Curcumin
Angiogenesis
title_short Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
title_full Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
title_fullStr Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
title_full_unstemmed Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
title_sort Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas
dc.creator.none.fl_str_mv Shan, B.
Schaaf, C.
Schmidt, A.
Lucia, K.
Buchfelder, M.
Losa, M.
Kuhlen, D.
Kreutzer, J.
Perone, Marcelo Javier
Arzt, Eduardo Simon
Stalla, G.K.
Renner, U.
author Shan, B.
author_facet Shan, B.
Schaaf, C.
Schmidt, A.
Lucia, K.
Buchfelder, M.
Losa, M.
Kuhlen, D.
Kreutzer, J.
Perone, Marcelo Javier
Arzt, Eduardo Simon
Stalla, G.K.
Renner, U.
author_role author
author2 Schaaf, C.
Schmidt, A.
Lucia, K.
Buchfelder, M.
Losa, M.
Kuhlen, D.
Kreutzer, J.
Perone, Marcelo Javier
Arzt, Eduardo Simon
Stalla, G.K.
Renner, U.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pituitary
Adenoma
Curcumin
Angiogenesis
topic Pituitary
Adenoma
Curcumin
Angiogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.
Fil: Shan, B.. Max Planck Institute of Psychiatry; Alemania
Fil: Schaaf, C.. Max Planck Institute of Psychiatry; Alemania
Fil: Schmidt, A.. Max Planck Institute of Psychiatry; Alemania
Fil: Lucia, K.. Max Planck Institute of Psychiatry; Alemania
Fil: Buchfelder, M.. Universitat Erlangen-Nuremberg; Alemania
Fil: Losa, M.. Istituto San Raffael; Italia
Fil: Kuhlen, D.. Universitat Technical Zu Munich; Alemania
Fil: Kreutzer, J.. Universitat Technical Zu Munich; Alemania
Fil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina
Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular. Laboratorio de Fisiología y Biología Molecular; Argentina
Fil: Stalla, G.K.. Max Planck Institute of Psychiatry; Alemania
Fil: Renner, U.. Max Planck Institute of Psychiatry; Alemania
description Curcumin (diferuloylmethane), a polyphenolic compound derived from the spice plant Curcuma longa, displays multiple actions on solid tumours including anti-angiogenic effects. Here we have studied in rodent and human pituitary tumour cells the influence of curcumin on the production of hypoxia inducible factor 1α (HIF1A) and vascular endothelial growth factor A (VEGFA), two key components involved in tumour neovascularisation through angiogenesis. Curcumin dose-dependently inhibited basal VEGFA secretion in corticotroph AtT20 mouse and lactosomatotroph GH3 rat pituitary tumour cells as well as in all human pituitary adenoma cell cultures (nZ32) studied. Under hypoxia-mimicking conditions (CoCl2 treatment) in AtT20 and GH3 cells as well as in all human pituitary adenoma cell cultures (nZ8) studied, curcumin strongly suppressed the induction of mRNA synthesis and protein production of HIF1A, the regulated subunit of the hypoxia-induced transcription factor HIF1. Curcumin also blocked hypoxiainducedmRNAsynthesis and secretion ofVEGFAinGH3 cells and in all human pituitary adenoma cell cultures investigated (nZ18). Thus, curcumin may inhibit pituitary adenoma progression not only through previously demonstrated antiproliferative and pro-apoptotic actions but also by its suppressive effects on pituitary tumour neovascularisation.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/69079
Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; et al.; Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas; BioScientifica; Journal of Endocrinology; 214; 3; 9-2012; 389-398
0022-0795
CONICET Digital
CONICET
url http://hdl.handle.net/11336/69079
identifier_str_mv Shan, B.; Schaaf, C.; Schmidt, A.; Lucia, K.; Buchfelder, M.; et al.; Curcumin suppresses HIF1A synthesis and VEGFA release in pituitary adenomas; BioScientifica; Journal of Endocrinology; 214; 3; 9-2012; 389-398
0022-0795
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1530/JOE-12-0207
info:eu-repo/semantics/altIdentifier/url/https://joe.bioscientifica.com/view/journals/joe/214/3/389.xml
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioScientifica
publisher.none.fl_str_mv BioScientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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