Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex

Autores
Fernandez Leon, Jose Alberto; Engelke, Douglas S.; Aquino Miranda, Guillermo; Goodson, Alexandria; Rasheed, María N.; Do Monte, Fabricio H.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic cortex (PL) respond to both threat-and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs. reward-approaching responses when an animals’ decision depends on previously associated memories. Using a conflict model in which male Long-Evans rats retrieve memories of shock and food-paired cues, we observed two distinct phenotypes during conflict: I) rats that continued to press a lever for food (Pressers); and ii) rats that exhibited a complete suppression in food seeking (Non-pressers). Single-unit recordings revealed that increased risk-taking behavior in Pressers is associated with persistent food-cue responses in PL, and reduced spontaneous activity in PL glutamatergic (PLGLUT) neurons during conflict. Activating PLGLUT neurons in Pressers attenuated foodseeking responses in a neutral context, whereas inhibiting PLGLUT neurons in Non pressers reduced defensive responses and increased food approaching during conflict. Our results establish a causal role for PLGLUT neurons in mediating individual variability in memory-based risky decision making by regulating threat-avoidance vs. reward-approach behaviors.
Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Engelke, Douglas S.. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Aquino Miranda, Guillermo. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Goodson, Alexandria. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados Unidos
Fil: Rasheed, María N.. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Do Monte, Fabricio H.. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados Unidos
Materia
DECISION-MAKING
ELECTROPHYSIOLOGY
FEAR
OPTOGENETICS
PRELIMBIC PREFRONTAL CORTEX
REWARD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173022
Acceder
id CONICETDig_8f9bac70b81c90a02700455ae8ca85ca
oai_identifier_str oai:ri.conicet.gov.ar:11336/173022
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortexFernandez Leon, Jose AlbertoEngelke, Douglas S.Aquino Miranda, GuillermoGoodson, AlexandriaRasheed, María N.Do Monte, Fabricio H.DECISION-MAKINGELECTROPHYSIOLOGYFEAROPTOGENETICSPRELIMBIC PREFRONTAL CORTEXREWARDhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic cortex (PL) respond to both threat-and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs. reward-approaching responses when an animals’ decision depends on previously associated memories. Using a conflict model in which male Long-Evans rats retrieve memories of shock and food-paired cues, we observed two distinct phenotypes during conflict: I) rats that continued to press a lever for food (Pressers); and ii) rats that exhibited a complete suppression in food seeking (Non-pressers). Single-unit recordings revealed that increased risk-taking behavior in Pressers is associated with persistent food-cue responses in PL, and reduced spontaneous activity in PL glutamatergic (PLGLUT) neurons during conflict. Activating PLGLUT neurons in Pressers attenuated foodseeking responses in a neutral context, whereas inhibiting PLGLUT neurons in Non pressers reduced defensive responses and increased food approaching during conflict. Our results establish a causal role for PLGLUT neurons in mediating individual variability in memory-based risky decision making by regulating threat-avoidance vs. reward-approach behaviors.Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina. University of Texas Health Science Center at Houston; Estados UnidosFil: Engelke, Douglas S.. University of Texas Health Science Center at Houston; Estados UnidosFil: Aquino Miranda, Guillermo. University of Texas Health Science Center at Houston; Estados UnidosFil: Goodson, Alexandria. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados UnidosFil: Rasheed, María N.. University of Texas Health Science Center at Houston; Estados UnidosFil: Do Monte, Fabricio H.. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados UnidoseLife Sciences Publications2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173022Fernandez Leon, Jose Alberto; Engelke, Douglas S.; Aquino Miranda, Guillermo; Goodson, Alexandria; Rasheed, María N.; et al.; Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex; eLife Sciences Publications; eLife; 10; 12-2021; 1-362050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/74950info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.74950info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:01:02Zoai:ri.conicet.gov.ar:11336/173022instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:01:02.623CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
title Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
spellingShingle Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
Fernandez Leon, Jose Alberto
DECISION-MAKING
ELECTROPHYSIOLOGY
FEAR
OPTOGENETICS
PRELIMBIC PREFRONTAL CORTEX
REWARD
title_short Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
title_full Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
title_fullStr Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
title_full_unstemmed Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
title_sort Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex
dc.creator.none.fl_str_mv Fernandez Leon, Jose Alberto
Engelke, Douglas S.
Aquino Miranda, Guillermo
Goodson, Alexandria
Rasheed, María N.
Do Monte, Fabricio H.
author Fernandez Leon, Jose Alberto
author_facet Fernandez Leon, Jose Alberto
Engelke, Douglas S.
Aquino Miranda, Guillermo
Goodson, Alexandria
Rasheed, María N.
Do Monte, Fabricio H.
author_role author
author2 Engelke, Douglas S.
Aquino Miranda, Guillermo
Goodson, Alexandria
Rasheed, María N.
Do Monte, Fabricio H.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv DECISION-MAKING
ELECTROPHYSIOLOGY
FEAR
OPTOGENETICS
PRELIMBIC PREFRONTAL CORTEX
REWARD
topic DECISION-MAKING
ELECTROPHYSIOLOGY
FEAR
OPTOGENETICS
PRELIMBIC PREFRONTAL CORTEX
REWARD
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic cortex (PL) respond to both threat-and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs. reward-approaching responses when an animals’ decision depends on previously associated memories. Using a conflict model in which male Long-Evans rats retrieve memories of shock and food-paired cues, we observed two distinct phenotypes during conflict: I) rats that continued to press a lever for food (Pressers); and ii) rats that exhibited a complete suppression in food seeking (Non-pressers). Single-unit recordings revealed that increased risk-taking behavior in Pressers is associated with persistent food-cue responses in PL, and reduced spontaneous activity in PL glutamatergic (PLGLUT) neurons during conflict. Activating PLGLUT neurons in Pressers attenuated foodseeking responses in a neutral context, whereas inhibiting PLGLUT neurons in Non pressers reduced defensive responses and increased food approaching during conflict. Our results establish a causal role for PLGLUT neurons in mediating individual variability in memory-based risky decision making by regulating threat-avoidance vs. reward-approach behaviors.
Fil: Fernandez Leon, Jose Alberto. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Engelke, Douglas S.. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Aquino Miranda, Guillermo. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Goodson, Alexandria. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados Unidos
Fil: Rasheed, María N.. University of Texas Health Science Center at Houston; Estados Unidos
Fil: Do Monte, Fabricio H.. University of Texas Health Science Center at Houston; Estados Unidos. Rice University; Estados Unidos
description The recollection of environmental cues associated with threat or reward allows animals to select the most appropriate behavioral responses. Neurons in the prelimbic cortex (PL) respond to both threat-and reward-associated cues. However, it remains unknown whether PL regulates threat-avoidance vs. reward-approaching responses when an animals’ decision depends on previously associated memories. Using a conflict model in which male Long-Evans rats retrieve memories of shock and food-paired cues, we observed two distinct phenotypes during conflict: I) rats that continued to press a lever for food (Pressers); and ii) rats that exhibited a complete suppression in food seeking (Non-pressers). Single-unit recordings revealed that increased risk-taking behavior in Pressers is associated with persistent food-cue responses in PL, and reduced spontaneous activity in PL glutamatergic (PLGLUT) neurons during conflict. Activating PLGLUT neurons in Pressers attenuated foodseeking responses in a neutral context, whereas inhibiting PLGLUT neurons in Non pressers reduced defensive responses and increased food approaching during conflict. Our results establish a causal role for PLGLUT neurons in mediating individual variability in memory-based risky decision making by regulating threat-avoidance vs. reward-approach behaviors.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173022
Fernandez Leon, Jose Alberto; Engelke, Douglas S.; Aquino Miranda, Guillermo; Goodson, Alexandria; Rasheed, María N.; et al.; Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex; eLife Sciences Publications; eLife; 10; 12-2021; 1-36
2050-084X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173022
identifier_str_mv Fernandez Leon, Jose Alberto; Engelke, Douglas S.; Aquino Miranda, Guillermo; Goodson, Alexandria; Rasheed, María N.; et al.; Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex; eLife Sciences Publications; eLife; 10; 12-2021; 1-36
2050-084X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/74950
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.74950
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife Sciences Publications
publisher.none.fl_str_mv eLife Sciences Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083150434795520
score 13.22299

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