Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems

Autores
Castro, Gabriela Tatiana; Filippa, Mauricio Andrés; Peralta, Cecilia Mariana; Davin, María Virginia; Almandoz, María Cristina; Gasull, Estela Isabel
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The solubilization and solvatochromic behavior of piroxicam (PRX) were analyzed using UV-vis spectroscopy in neat (protic and aprotic) and binary solvent mixtures. The effects of solvent dipolarity/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.
Fil: Castro, Gabriela Tatiana. Universidad Nacional de San Luis; Argentina
Fil: Filippa, Mauricio Andrés. Universidad Nacional de San Luis; Argentina
Fil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Davin, María Virginia. Universidad Nacional de San Luis; Argentina
Fil: Almandoz, María Cristina. Universidad Nacional de San Luis; Argentina
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis; Argentina
Materia
Binary Mixtures
Piroxicam
Preferential Solvation
Solvatochomism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64500
Acceder
id CONICETDig_8f514e039da59be1744ada99d0d04a1a
oai_identifier_str oai:ri.conicet.gov.ar:11336/64500
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary SystemsCastro, Gabriela TatianaFilippa, Mauricio AndrésPeralta, Cecilia MarianaDavin, María VirginiaAlmandoz, María CristinaGasull, Estela IsabelBinary MixturesPiroxicamPreferential SolvationSolvatochomismhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The solubilization and solvatochromic behavior of piroxicam (PRX) were analyzed using UV-vis spectroscopy in neat (protic and aprotic) and binary solvent mixtures. The effects of solvent dipolarity/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.Fil: Castro, Gabriela Tatiana. Universidad Nacional de San Luis; ArgentinaFil: Filippa, Mauricio Andrés. Universidad Nacional de San Luis; ArgentinaFil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Davin, María Virginia. Universidad Nacional de San Luis; ArgentinaFil: Almandoz, María Cristina. Universidad Nacional de San Luis; ArgentinaFil: Gasull, Estela Isabel. Universidad Nacional de San Luis; ArgentinaOldenbourg Verlag2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64500Castro, Gabriela Tatiana; Filippa, Mauricio Andrés; Peralta, Cecilia Mariana; Davin, María Virginia; Almandoz, María Cristina; et al.; Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems; Oldenbourg Verlag; Zeitschrift für Physikalische Chemie; 232; 2; 2-2018; 257-2800942-9352CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.degruyter.com/view/j/zpch.ahead-of-print/zpch-2017-0946/zpch-2017-0946.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/zpch-2017-0946info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:26Zoai:ri.conicet.gov.ar:11336/64500instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:26.575CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
title Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
spellingShingle Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
Castro, Gabriela Tatiana
Binary Mixtures
Piroxicam
Preferential Solvation
Solvatochomism
title_short Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
title_full Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
title_fullStr Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
title_full_unstemmed Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
title_sort Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems
dc.creator.none.fl_str_mv Castro, Gabriela Tatiana
Filippa, Mauricio Andrés
Peralta, Cecilia Mariana
Davin, María Virginia
Almandoz, María Cristina
Gasull, Estela Isabel
author Castro, Gabriela Tatiana
author_facet Castro, Gabriela Tatiana
Filippa, Mauricio Andrés
Peralta, Cecilia Mariana
Davin, María Virginia
Almandoz, María Cristina
Gasull, Estela Isabel
author_role author
author2 Filippa, Mauricio Andrés
Peralta, Cecilia Mariana
Davin, María Virginia
Almandoz, María Cristina
Gasull, Estela Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Binary Mixtures
Piroxicam
Preferential Solvation
Solvatochomism
topic Binary Mixtures
Piroxicam
Preferential Solvation
Solvatochomism
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The solubilization and solvatochromic behavior of piroxicam (PRX) were analyzed using UV-vis spectroscopy in neat (protic and aprotic) and binary solvent mixtures. The effects of solvent dipolarity/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.
Fil: Castro, Gabriela Tatiana. Universidad Nacional de San Luis; Argentina
Fil: Filippa, Mauricio Andrés. Universidad Nacional de San Luis; Argentina
Fil: Peralta, Cecilia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Davin, María Virginia. Universidad Nacional de San Luis; Argentina
Fil: Almandoz, María Cristina. Universidad Nacional de San Luis; Argentina
Fil: Gasull, Estela Isabel. Universidad Nacional de San Luis; Argentina
description The solubilization and solvatochromic behavior of piroxicam (PRX) were analyzed using UV-vis spectroscopy in neat (protic and aprotic) and binary solvent mixtures. The effects of solvent dipolarity/polarizability and solvent?solute hydrogen bonding interactions on the absorption maxima were evaluated by means of the linear solvation energy relationship concept of Kamlet and Taft. This analysis indicated that both interactions play an important role in the position of the absorption maxima in neat solvents. While, the PRX solubility depends on the solute?solvent specific interactions, polarizability and the cohesive forces of the solvent, manifested mainly by means of the Hildebrand?s solubility parameter. Preferential solvation (PS) was studied in 10 binary mixtures. A non-ideal behavior of the wavenumber curve as the function of analytical mole fraction of co-solvent was detected. Index of preferential solvation, as well as the influence of solvent parameters were calculated. The process of dissolution was analyzed in aqueous binary mixtures of ethanol, ethylene glycol and propylene glycol. They were not spontaneous in all proportions, but when water concentration decreases in the mixtures, the process becomes more spontaneous.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64500
Castro, Gabriela Tatiana; Filippa, Mauricio Andrés; Peralta, Cecilia Mariana; Davin, María Virginia; Almandoz, María Cristina; et al.; Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems; Oldenbourg Verlag; Zeitschrift für Physikalische Chemie; 232; 2; 2-2018; 257-280
0942-9352
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64500
identifier_str_mv Castro, Gabriela Tatiana; Filippa, Mauricio Andrés; Peralta, Cecilia Mariana; Davin, María Virginia; Almandoz, María Cristina; et al.; Solubility and Preferential Solvation of Piroxicam in Neat Solvents and Binary Systems; Oldenbourg Verlag; Zeitschrift für Physikalische Chemie; 232; 2; 2-2018; 257-280
0942-9352
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.degruyter.com/view/j/zpch.ahead-of-print/zpch-2017-0946/zpch-2017-0946.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/zpch-2017-0946
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oldenbourg Verlag
publisher.none.fl_str_mv Oldenbourg Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269225015574528
score 13.13397

Publicaciones similares