Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration

Autores
Ordieres López, María Graciela; Rosin, Carina; Miño, Jorge; Rodriguez, Georgina Emma
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of antagonist SR48692, suggesting the involvement of high affinity neurotensin (NTS1) receptor. Diverse evidences suggest a relationship between neurotensinergic system and glycemia levels. For this reason, potential Na+, K+-ATPase regulation by neurotensin in brain membranes obtained from rats turned hyperglycaemic was explored. As a model to produce diabetes mellitus, rats were administered with Streptozotocin (STZ), a specific toxic agent to the pancreatic beta cells. Our findings indicated that Na+, K+-ATPase activity in synaptosomal membranes isolated from diabetic rats failed to respond to neurotensin. The treatment decreased the affinity of NTS1 receptor for neurotensin and the expression of Na+, K+-ATPase alpha3 subunit in cerebral cortex. The results led us to conclude that STZ administration alters the response of Na+, K+-ATPase to neurotensin. Such effect seems to involve a decrease in enzyme alpha3 isoform expression and NTS1 receptor affinity for neurotensin.
Fil: Ordieres López, María Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
Fil: Rosin, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
Fil: Miño, Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
Materia
Neurotensin
Na/K-Atpase
Streptozotocin
Diabetes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8503
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8503
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Na+, K+-ATPase response to neurotensin is altered by streptozotocin administrationOrdieres López, María GracielaRosin, CarinaMiño, JorgeRodriguez, Georgina EmmaNeurotensinNa/K-AtpaseStreptozotocinDiabeteshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of antagonist SR48692, suggesting the involvement of high affinity neurotensin (NTS1) receptor. Diverse evidences suggest a relationship between neurotensinergic system and glycemia levels. For this reason, potential Na+, K+-ATPase regulation by neurotensin in brain membranes obtained from rats turned hyperglycaemic was explored. As a model to produce diabetes mellitus, rats were administered with Streptozotocin (STZ), a specific toxic agent to the pancreatic beta cells. Our findings indicated that Na+, K+-ATPase activity in synaptosomal membranes isolated from diabetic rats failed to respond to neurotensin. The treatment decreased the affinity of NTS1 receptor for neurotensin and the expression of Na+, K+-ATPase alpha3 subunit in cerebral cortex. The results led us to conclude that STZ administration alters the response of Na+, K+-ATPase to neurotensin. Such effect seems to involve a decrease in enzyme alpha3 isoform expression and NTS1 receptor affinity for neurotensin.Fil: Ordieres López, María Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; ArgentinaFil: Rosin, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; ArgentinaFil: Miño, Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; ArgentinaResearch Trends2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8503Ordieres López, María Graciela; Rosin, Carina; Miño, Jorge; Rodriguez, Georgina Emma; Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration; Research Trends; Current Topics in Peptide & Protein Research; 14; 9-2013; 19-260972-4524enginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=14&tid=26&aid=5153&pub=2013&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:01Zoai:ri.conicet.gov.ar:11336/8503instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:01.417CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
title Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
spellingShingle Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
Ordieres López, María Graciela
Neurotensin
Na/K-Atpase
Streptozotocin
Diabetes
title_short Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
title_full Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
title_fullStr Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
title_full_unstemmed Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
title_sort Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration
dc.creator.none.fl_str_mv Ordieres López, María Graciela
Rosin, Carina
Miño, Jorge
Rodriguez, Georgina Emma
author Ordieres López, María Graciela
author_facet Ordieres López, María Graciela
Rosin, Carina
Miño, Jorge
Rodriguez, Georgina Emma
author_role author
author2 Rosin, Carina
Miño, Jorge
Rodriguez, Georgina Emma
author2_role author
author
author
dc.subject.none.fl_str_mv Neurotensin
Na/K-Atpase
Streptozotocin
Diabetes
topic Neurotensin
Na/K-Atpase
Streptozotocin
Diabetes
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of antagonist SR48692, suggesting the involvement of high affinity neurotensin (NTS1) receptor. Diverse evidences suggest a relationship between neurotensinergic system and glycemia levels. For this reason, potential Na+, K+-ATPase regulation by neurotensin in brain membranes obtained from rats turned hyperglycaemic was explored. As a model to produce diabetes mellitus, rats were administered with Streptozotocin (STZ), a specific toxic agent to the pancreatic beta cells. Our findings indicated that Na+, K+-ATPase activity in synaptosomal membranes isolated from diabetic rats failed to respond to neurotensin. The treatment decreased the affinity of NTS1 receptor for neurotensin and the expression of Na+, K+-ATPase alpha3 subunit in cerebral cortex. The results led us to conclude that STZ administration alters the response of Na+, K+-ATPase to neurotensin. Such effect seems to involve a decrease in enzyme alpha3 isoform expression and NTS1 receptor affinity for neurotensin.
Fil: Ordieres López, María Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
Fil: Rosin, Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
Fil: Miño, Jorge. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencias "profesor Eduardo de Robertis"; Argentina
description Neurotensin is a basic tridecapeptide which can act as a neuromodulator or a neurotransmitter and binds to a group of receptors. Neurotensin is able to inhibit Na+, K+-ATPase activity, an effect blocked by the presence of antagonist SR48692, suggesting the involvement of high affinity neurotensin (NTS1) receptor. Diverse evidences suggest a relationship between neurotensinergic system and glycemia levels. For this reason, potential Na+, K+-ATPase regulation by neurotensin in brain membranes obtained from rats turned hyperglycaemic was explored. As a model to produce diabetes mellitus, rats were administered with Streptozotocin (STZ), a specific toxic agent to the pancreatic beta cells. Our findings indicated that Na+, K+-ATPase activity in synaptosomal membranes isolated from diabetic rats failed to respond to neurotensin. The treatment decreased the affinity of NTS1 receptor for neurotensin and the expression of Na+, K+-ATPase alpha3 subunit in cerebral cortex. The results led us to conclude that STZ administration alters the response of Na+, K+-ATPase to neurotensin. Such effect seems to involve a decrease in enzyme alpha3 isoform expression and NTS1 receptor affinity for neurotensin.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8503
Ordieres López, María Graciela; Rosin, Carina; Miño, Jorge; Rodriguez, Georgina Emma; Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration; Research Trends; Current Topics in Peptide & Protein Research; 14; 9-2013; 19-26
0972-4524
url http://hdl.handle.net/11336/8503
identifier_str_mv Ordieres López, María Graciela; Rosin, Carina; Miño, Jorge; Rodriguez, Georgina Emma; Na+, K+-ATPase response to neurotensin is altered by streptozotocin administration; Research Trends; Current Topics in Peptide & Protein Research; 14; 9-2013; 19-26
0972-4524
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=14&tid=26&aid=5153&pub=2013&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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