Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation

Autores
Lavandera, Jimena Veronica; Reus, Verónica; Sain, Juliana; Bernal, Claudio Adrian; González, Marcela Aída
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids interaction affects brain structure and function. Unsaturated fatty acids (UFAs) generate oxygenated lipid-derived eicosanoids which modulate the inflammatory response. The presence of trans fatty acids (TFA) in neuronal membranes can favor to generation of pro-oxidant metabolites. OBJECTIVE: This study evaluated the effect of supplementation with TFA to diets containing different proportions of FA, on the oxidative stress (OS) generation and the inflammatory response in mice brain and liver. METHODS: CF1 mice were fed diets (16 weeks) with olive (O), corn (C) or rapeseed (R) oils. OS parameters and gene expression of some key liver and brain enzymes involved in OS production were evaluated. RESULTS: In brain and liver, lipoperoxidation was increased and catalase activity was decreased in C. In brain, glutathione was diminished by supplementation with TFA in all diets and histological sections showed lymphocytes in O and C. In liver, decreased amount of lipid vacuoles and increased of cyclooxygenase-1 (COX-1) and PPARγ mRNA levels were observed in R and Rt. IL-1b and IL-6 in serum were augmented in O and Ot. CONCLUSIONS: Rapeseed oil could have protective effects on the development of OS and inflammation, while TFA supplementation did not showed marked effects on these parameters.
Fil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Reus, Verónica. Universidad Nacional del Litoral; Argentina
Fil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Materia
CYCLOOXYGENASE
EDIBLE OILS
INFLAMMATION; TRANS FATTY ACIDS
MONOUNSATURATED FATTY ACIDS
POLYUNSATURATED FATTY ACIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167699
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/167699
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementationLavandera, Jimena VeronicaReus, VerónicaSain, JulianaBernal, Claudio AdrianGonzález, Marcela AídaCYCLOOXYGENASEEDIBLE OILSINFLAMMATION; TRANS FATTY ACIDSMONOUNSATURATED FATTY ACIDSPOLYUNSATURATED FATTY ACIDShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1BACKGROUND: Arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids interaction affects brain structure and function. Unsaturated fatty acids (UFAs) generate oxygenated lipid-derived eicosanoids which modulate the inflammatory response. The presence of trans fatty acids (TFA) in neuronal membranes can favor to generation of pro-oxidant metabolites. OBJECTIVE: This study evaluated the effect of supplementation with TFA to diets containing different proportions of FA, on the oxidative stress (OS) generation and the inflammatory response in mice brain and liver. METHODS: CF1 mice were fed diets (16 weeks) with olive (O), corn (C) or rapeseed (R) oils. OS parameters and gene expression of some key liver and brain enzymes involved in OS production were evaluated. RESULTS: In brain and liver, lipoperoxidation was increased and catalase activity was decreased in C. In brain, glutathione was diminished by supplementation with TFA in all diets and histological sections showed lymphocytes in O and C. In liver, decreased amount of lipid vacuoles and increased of cyclooxygenase-1 (COX-1) and PPARγ mRNA levels were observed in R and Rt. IL-1b and IL-6 in serum were augmented in O and Ot. CONCLUSIONS: Rapeseed oil could have protective effects on the development of OS and inflammation, while TFA supplementation did not showed marked effects on these parameters.Fil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Reus, Verónica. Universidad Nacional del Litoral; ArgentinaFil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaFil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; ArgentinaIOS Press2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167699Lavandera, Jimena Veronica; Reus, Verónica; Sain, Juliana; Bernal, Claudio Adrian; González, Marcela Aída; Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation; IOS Press; Mediterranean Journal of Nutrition and Metabolism; 14; 1; 3-2021; 91-1061973-798X1973-7998CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/mediterranean-journal-of-nutrition-and-metabolism/mnm200508info:eu-repo/semantics/altIdentifier/doi/10.3233/MNM-200508info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:12Zoai:ri.conicet.gov.ar:11336/167699instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:12.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
title Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
spellingShingle Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
Lavandera, Jimena Veronica
CYCLOOXYGENASE
EDIBLE OILS
INFLAMMATION; TRANS FATTY ACIDS
MONOUNSATURATED FATTY ACIDS
POLYUNSATURATED FATTY ACIDS
title_short Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
title_full Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
title_fullStr Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
title_full_unstemmed Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
title_sort Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation
dc.creator.none.fl_str_mv Lavandera, Jimena Veronica
Reus, Verónica
Sain, Juliana
Bernal, Claudio Adrian
González, Marcela Aída
author Lavandera, Jimena Veronica
author_facet Lavandera, Jimena Veronica
Reus, Verónica
Sain, Juliana
Bernal, Claudio Adrian
González, Marcela Aída
author_role author
author2 Reus, Verónica
Sain, Juliana
Bernal, Claudio Adrian
González, Marcela Aída
author2_role author
author
author
author
dc.subject.none.fl_str_mv CYCLOOXYGENASE
EDIBLE OILS
INFLAMMATION; TRANS FATTY ACIDS
MONOUNSATURATED FATTY ACIDS
POLYUNSATURATED FATTY ACIDS
topic CYCLOOXYGENASE
EDIBLE OILS
INFLAMMATION; TRANS FATTY ACIDS
MONOUNSATURATED FATTY ACIDS
POLYUNSATURATED FATTY ACIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv BACKGROUND: Arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids interaction affects brain structure and function. Unsaturated fatty acids (UFAs) generate oxygenated lipid-derived eicosanoids which modulate the inflammatory response. The presence of trans fatty acids (TFA) in neuronal membranes can favor to generation of pro-oxidant metabolites. OBJECTIVE: This study evaluated the effect of supplementation with TFA to diets containing different proportions of FA, on the oxidative stress (OS) generation and the inflammatory response in mice brain and liver. METHODS: CF1 mice were fed diets (16 weeks) with olive (O), corn (C) or rapeseed (R) oils. OS parameters and gene expression of some key liver and brain enzymes involved in OS production were evaluated. RESULTS: In brain and liver, lipoperoxidation was increased and catalase activity was decreased in C. In brain, glutathione was diminished by supplementation with TFA in all diets and histological sections showed lymphocytes in O and C. In liver, decreased amount of lipid vacuoles and increased of cyclooxygenase-1 (COX-1) and PPARγ mRNA levels were observed in R and Rt. IL-1b and IL-6 in serum were augmented in O and Ot. CONCLUSIONS: Rapeseed oil could have protective effects on the development of OS and inflammation, while TFA supplementation did not showed marked effects on these parameters.
Fil: Lavandera, Jimena Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Reus, Verónica. Universidad Nacional del Litoral; Argentina
Fil: Sain, Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: Bernal, Claudio Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
Fil: González, Marcela Aída. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas. Cátedra de Bromatología y Nutrición; Argentina
description BACKGROUND: Arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acids interaction affects brain structure and function. Unsaturated fatty acids (UFAs) generate oxygenated lipid-derived eicosanoids which modulate the inflammatory response. The presence of trans fatty acids (TFA) in neuronal membranes can favor to generation of pro-oxidant metabolites. OBJECTIVE: This study evaluated the effect of supplementation with TFA to diets containing different proportions of FA, on the oxidative stress (OS) generation and the inflammatory response in mice brain and liver. METHODS: CF1 mice were fed diets (16 weeks) with olive (O), corn (C) or rapeseed (R) oils. OS parameters and gene expression of some key liver and brain enzymes involved in OS production were evaluated. RESULTS: In brain and liver, lipoperoxidation was increased and catalase activity was decreased in C. In brain, glutathione was diminished by supplementation with TFA in all diets and histological sections showed lymphocytes in O and C. In liver, decreased amount of lipid vacuoles and increased of cyclooxygenase-1 (COX-1) and PPARγ mRNA levels were observed in R and Rt. IL-1b and IL-6 in serum were augmented in O and Ot. CONCLUSIONS: Rapeseed oil could have protective effects on the development of OS and inflammation, while TFA supplementation did not showed marked effects on these parameters.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167699
Lavandera, Jimena Veronica; Reus, Verónica; Sain, Juliana; Bernal, Claudio Adrian; González, Marcela Aída; Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation; IOS Press; Mediterranean Journal of Nutrition and Metabolism; 14; 1; 3-2021; 91-106
1973-798X
1973-7998
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167699
identifier_str_mv Lavandera, Jimena Veronica; Reus, Verónica; Sain, Juliana; Bernal, Claudio Adrian; González, Marcela Aída; Dietary n-9, n-6 and n-3 fatty acids modulate the oxidative stress in brain and liver of mice: Effect of trans fatty acids supplementation; IOS Press; Mediterranean Journal of Nutrition and Metabolism; 14; 1; 3-2021; 91-106
1973-798X
1973-7998
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/mediterranean-journal-of-nutrition-and-metabolism/mnm200508
info:eu-repo/semantics/altIdentifier/doi/10.3233/MNM-200508
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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