Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods
- Autores
- Lick, Ileana Daniela; Villalba, Maria Luisa; Gavernet, Luciana
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The enalapril maleate (EM) decomposition to diketopiperazine was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 5 ◦C min−1. The activation energy value was obtained (198 kJ mol−1) from the Kissinger–Akahira–Sunose isoconversional method. Isothermal experiments were simulated (125, 130, 135 and 155 ◦C) using the model-free method, employing only the activation energy value. The reaction model of the process was studied by means of the master-plot method. The reaction mechanism depends on the temperature; for experiments below 235 ◦C, the probable mechanism is nucleation. Instead, when the temperature overcomes the EM melting point, the reaction occurs in liquid state and its kinetics is better described by first order reaction. To avoid the complexity of model changes, experimental results are fitted using the model-free method.
Fil: Lick, Ileana Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina
Fil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Gavernet, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina - Materia
-
ENALAPRIL MALEATE
DIKETOPIPERAZINE
SYNTHESIS
KINETIC STUDY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/245848
Ver los metadatos del registro completo
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Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methodsLick, Ileana DanielaVillalba, Maria LuisaGavernet, LucianaENALAPRIL MALEATEDIKETOPIPERAZINESYNTHESISKINETIC STUDYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The enalapril maleate (EM) decomposition to diketopiperazine was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 5 ◦C min−1. The activation energy value was obtained (198 kJ mol−1) from the Kissinger–Akahira–Sunose isoconversional method. Isothermal experiments were simulated (125, 130, 135 and 155 ◦C) using the model-free method, employing only the activation energy value. The reaction model of the process was studied by means of the master-plot method. The reaction mechanism depends on the temperature; for experiments below 235 ◦C, the probable mechanism is nucleation. Instead, when the temperature overcomes the EM melting point, the reaction occurs in liquid state and its kinetics is better described by first order reaction. To avoid the complexity of model changes, experimental results are fitted using the model-free method.Fil: Lick, Ileana Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; ArgentinaFil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Gavernet, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; ArgentinaElsevier Science2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/245848Lick, Ileana Daniela; Villalba, Maria Luisa; Gavernet, Luciana; Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods; Elsevier Science; Thermochimica Acta; 527; 1-2012; 143-1470040-6031CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0040603111005193info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tca.2011.10.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:23:23Zoai:ri.conicet.gov.ar:11336/245848instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:23:23.276CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
title |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
spellingShingle |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods Lick, Ileana Daniela ENALAPRIL MALEATE DIKETOPIPERAZINE SYNTHESIS KINETIC STUDY |
title_short |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
title_full |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
title_fullStr |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
title_full_unstemmed |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
title_sort |
Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods |
dc.creator.none.fl_str_mv |
Lick, Ileana Daniela Villalba, Maria Luisa Gavernet, Luciana |
author |
Lick, Ileana Daniela |
author_facet |
Lick, Ileana Daniela Villalba, Maria Luisa Gavernet, Luciana |
author_role |
author |
author2 |
Villalba, Maria Luisa Gavernet, Luciana |
author2_role |
author author |
dc.subject.none.fl_str_mv |
ENALAPRIL MALEATE DIKETOPIPERAZINE SYNTHESIS KINETIC STUDY |
topic |
ENALAPRIL MALEATE DIKETOPIPERAZINE SYNTHESIS KINETIC STUDY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The enalapril maleate (EM) decomposition to diketopiperazine was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 5 ◦C min−1. The activation energy value was obtained (198 kJ mol−1) from the Kissinger–Akahira–Sunose isoconversional method. Isothermal experiments were simulated (125, 130, 135 and 155 ◦C) using the model-free method, employing only the activation energy value. The reaction model of the process was studied by means of the master-plot method. The reaction mechanism depends on the temperature; for experiments below 235 ◦C, the probable mechanism is nucleation. Instead, when the temperature overcomes the EM melting point, the reaction occurs in liquid state and its kinetics is better described by first order reaction. To avoid the complexity of model changes, experimental results are fitted using the model-free method. Fil: Lick, Ileana Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Ciencias Aplicadas "Dr. Jorge J. Ronco". Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Ciencias Aplicadas; Argentina Fil: Villalba, Maria Luisa. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Gavernet, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Química Medicinal; Argentina |
description |
The enalapril maleate (EM) decomposition to diketopiperazine was monitored in helium flow by thermogravimetry at different heating rates between 0.2 and 5 ◦C min−1. The activation energy value was obtained (198 kJ mol−1) from the Kissinger–Akahira–Sunose isoconversional method. Isothermal experiments were simulated (125, 130, 135 and 155 ◦C) using the model-free method, employing only the activation energy value. The reaction model of the process was studied by means of the master-plot method. The reaction mechanism depends on the temperature; for experiments below 235 ◦C, the probable mechanism is nucleation. Instead, when the temperature overcomes the EM melting point, the reaction occurs in liquid state and its kinetics is better described by first order reaction. To avoid the complexity of model changes, experimental results are fitted using the model-free method. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/245848 Lick, Ileana Daniela; Villalba, Maria Luisa; Gavernet, Luciana; Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods; Elsevier Science; Thermochimica Acta; 527; 1-2012; 143-147 0040-6031 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/245848 |
identifier_str_mv |
Lick, Ileana Daniela; Villalba, Maria Luisa; Gavernet, Luciana; Synthesis of diketopiperazine: A kinetic study by Means of thermoanalytical methods; Elsevier Science; Thermochimica Acta; 527; 1-2012; 143-147 0040-6031 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0040603111005193 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tca.2011.10.020 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614228313374720 |
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13.070432 |