Galectin-3 prospects as a therapeutic agent for multiple sclerosis

Autores
Thomas, Laura; Pasquini, Laura Andrea
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervoussystem (CNS), allowing rapid conduction of the neuralaction potential and giving trophic support to axons. OLGs undergoa series of changes throughout their life cycle: first, uponneural stem cell commitment to the OLG lineage, cells referredto as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecularmarkers like platelet-derived growth factor receptor alpha andneural/glial antigen 2; next, in an intermediate stage called pre-OLG, OLGs are more ramified and express CNPase, Olig1 andO4, among others; finally, cells develop into myelin formingcells which express molecular markers like myelin basic protein(MBP), adenomatous polyposis polyposis and proteolipidprotein (Franklin et al., 2017). Worth pointing out, the actincytoskeleton plays an important role in OLG maturation, as itevolves from pro-polymerization to pro-depolymerization dynamics,which allows axon ensheathing. These mechanisms arecontrolled in part by the relationship between MBP and actindisassembly proteins such as cofilin-1 and gelsolin. The latterare normally sequestered and inactivated by phosphatidylinositol4,5-bisphosphate present in the plasma membrane. WhenMBP is expressed in mature OLG, it competes with gelsolin andcofilin-1 for phosphatidylinositol 4,5-bisphosphate binding,displacing and hence activating them, to trigger the disassemblyof actin filaments.
Fil: Thomas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Pasquini, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
galectin-3
multiple esclerosis
oligodendrocytes
myelin
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130709
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/130709
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Galectin-3 prospects as a therapeutic agent for multiple sclerosisThomas, LauraPasquini, Laura Andreagalectin-3multiple esclerosisoligodendrocytesmyelinhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervoussystem (CNS), allowing rapid conduction of the neuralaction potential and giving trophic support to axons. OLGs undergoa series of changes throughout their life cycle: first, uponneural stem cell commitment to the OLG lineage, cells referredto as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecularmarkers like platelet-derived growth factor receptor alpha andneural/glial antigen 2; next, in an intermediate stage called pre-OLG, OLGs are more ramified and express CNPase, Olig1 andO4, among others; finally, cells develop into myelin formingcells which express molecular markers like myelin basic protein(MBP), adenomatous polyposis polyposis and proteolipidprotein (Franklin et al., 2017). Worth pointing out, the actincytoskeleton plays an important role in OLG maturation, as itevolves from pro-polymerization to pro-depolymerization dynamics,which allows axon ensheathing. These mechanisms arecontrolled in part by the relationship between MBP and actindisassembly proteins such as cofilin-1 and gelsolin. The latterare normally sequestered and inactivated by phosphatidylinositol4,5-bisphosphate present in the plasma membrane. WhenMBP is expressed in mature OLG, it competes with gelsolin andcofilin-1 for phosphatidylinositol 4,5-bisphosphate binding,displacing and hence activating them, to trigger the disassemblyof actin filaments.Fil: Thomas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Pasquini, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaShenyang Editorial Dept Neural Regeneration Res2019-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130709Thomas, Laura; Pasquini, Laura Andrea; Galectin-3 prospects as a therapeutic agent for multiple sclerosis; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 8; 8-2019; 1380-13821673-5374CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.253521info:eu-repo/semantics/altIdentifier/url/https://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1380;epage=1382;aulast=Thomasinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:51Zoai:ri.conicet.gov.ar:11336/130709instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:51.684CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Galectin-3 prospects as a therapeutic agent for multiple sclerosis
title Galectin-3 prospects as a therapeutic agent for multiple sclerosis
spellingShingle Galectin-3 prospects as a therapeutic agent for multiple sclerosis
Thomas, Laura
galectin-3
multiple esclerosis
oligodendrocytes
myelin
title_short Galectin-3 prospects as a therapeutic agent for multiple sclerosis
title_full Galectin-3 prospects as a therapeutic agent for multiple sclerosis
title_fullStr Galectin-3 prospects as a therapeutic agent for multiple sclerosis
title_full_unstemmed Galectin-3 prospects as a therapeutic agent for multiple sclerosis
title_sort Galectin-3 prospects as a therapeutic agent for multiple sclerosis
dc.creator.none.fl_str_mv Thomas, Laura
Pasquini, Laura Andrea
author Thomas, Laura
author_facet Thomas, Laura
Pasquini, Laura Andrea
author_role author
author2 Pasquini, Laura Andrea
author2_role author
dc.subject.none.fl_str_mv galectin-3
multiple esclerosis
oligodendrocytes
myelin
topic galectin-3
multiple esclerosis
oligodendrocytes
myelin
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervoussystem (CNS), allowing rapid conduction of the neuralaction potential and giving trophic support to axons. OLGs undergoa series of changes throughout their life cycle: first, uponneural stem cell commitment to the OLG lineage, cells referredto as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecularmarkers like platelet-derived growth factor receptor alpha andneural/glial antigen 2; next, in an intermediate stage called pre-OLG, OLGs are more ramified and express CNPase, Olig1 andO4, among others; finally, cells develop into myelin formingcells which express molecular markers like myelin basic protein(MBP), adenomatous polyposis polyposis and proteolipidprotein (Franklin et al., 2017). Worth pointing out, the actincytoskeleton plays an important role in OLG maturation, as itevolves from pro-polymerization to pro-depolymerization dynamics,which allows axon ensheathing. These mechanisms arecontrolled in part by the relationship between MBP and actindisassembly proteins such as cofilin-1 and gelsolin. The latterare normally sequestered and inactivated by phosphatidylinositol4,5-bisphosphate present in the plasma membrane. WhenMBP is expressed in mature OLG, it competes with gelsolin andcofilin-1 for phosphatidylinositol 4,5-bisphosphate binding,displacing and hence activating them, to trigger the disassemblyof actin filaments.
Fil: Thomas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Pasquini, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description Galectin-3 (Gal-3) in oligodendrocyte (OLG) differentiation:OLGs are the cells in charge of myelination in the central nervoussystem (CNS), allowing rapid conduction of the neuralaction potential and giving trophic support to axons. OLGs undergoa series of changes throughout their life cycle: first, uponneural stem cell commitment to the OLG lineage, cells referredto as OLG precursor cells (OPC) present a bipolar morphology,have proliferative and migratory capacity and express molecularmarkers like platelet-derived growth factor receptor alpha andneural/glial antigen 2; next, in an intermediate stage called pre-OLG, OLGs are more ramified and express CNPase, Olig1 andO4, among others; finally, cells develop into myelin formingcells which express molecular markers like myelin basic protein(MBP), adenomatous polyposis polyposis and proteolipidprotein (Franklin et al., 2017). Worth pointing out, the actincytoskeleton plays an important role in OLG maturation, as itevolves from pro-polymerization to pro-depolymerization dynamics,which allows axon ensheathing. These mechanisms arecontrolled in part by the relationship between MBP and actindisassembly proteins such as cofilin-1 and gelsolin. The latterare normally sequestered and inactivated by phosphatidylinositol4,5-bisphosphate present in the plasma membrane. WhenMBP is expressed in mature OLG, it competes with gelsolin andcofilin-1 for phosphatidylinositol 4,5-bisphosphate binding,displacing and hence activating them, to trigger the disassemblyof actin filaments.
publishDate 2019
dc.date.none.fl_str_mv 2019-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130709
Thomas, Laura; Pasquini, Laura Andrea; Galectin-3 prospects as a therapeutic agent for multiple sclerosis; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 8; 8-2019; 1380-1382
1673-5374
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130709
identifier_str_mv Thomas, Laura; Pasquini, Laura Andrea; Galectin-3 prospects as a therapeutic agent for multiple sclerosis; Shenyang Editorial Dept Neural Regeneration Res; Neural Regeneration Research; 14; 8; 8-2019; 1380-1382
1673-5374
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4103/1673-5374.253521
info:eu-repo/semantics/altIdentifier/url/https://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1380;epage=1382;aulast=Thomas
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
publisher.none.fl_str_mv Shenyang Editorial Dept Neural Regeneration Res
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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