Boron biodistribution study in colorectal liver metastases patients in Argentina
- Autores
- Cardoso Cúneo, Jorge Eduardo Carlos; Nievas, S.; Pereira, M.; Schwint, Amanda Elena; Trivillin, Verónica Andrea; Pozzi, Emiliano César Cayetano; Heber, Elisa Mercedes; Monti Hughes, Andrea; Sanchez, P.; Bumaschny, E.; Itoiz, María Elina; Liberman, Susana Alcira
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible.
Fil: Cardoso Cúneo, Jorge Eduardo Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Nievas, S.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina
Fil: Pereira, M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Heber, Elisa Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sanchez, P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Bumaschny, E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Itoiz, María Elina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Liberman, Susana Alcira. Comisión Nacional de Energía Atómica; Argentina - Materia
-
Boron neutron capture therapy
Unresectable colorectal liver metastases
10B biodistribution
Hepatic autograft - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/157329
Ver los metadatos del registro completo
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Boron biodistribution study in colorectal liver metastases patients in ArgentinaCardoso Cúneo, Jorge Eduardo CarlosNievas, S.Pereira, M.Schwint, Amanda ElenaTrivillin, Verónica AndreaPozzi, Emiliano César CayetanoHeber, Elisa MercedesMonti Hughes, AndreaSanchez, P.Bumaschny, E.Itoiz, María ElinaLiberman, Susana AlciraBoron neutron capture therapyUnresectable colorectal liver metastases10B biodistributionHepatic autografthttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible.Fil: Cardoso Cúneo, Jorge Eduardo Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Nievas, S.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Pereira, M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Heber, Elisa Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez, P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Bumaschny, E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Itoiz, María Elina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Liberman, Susana Alcira. Comisión Nacional de Energía Atómica; ArgentinaPergamon-Elsevier Science Ltd2009-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/157329Cardoso Cúneo, Jorge Eduardo Carlos; Nievas, S.; Pereira, M.; Schwint, Amanda Elena; Trivillin, Verónica Andrea; et al.; Boron biodistribution study in colorectal liver metastases patients in Argentina; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-2009; 76-790969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804309002504info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2009.03.021info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:13:16Zoai:ri.conicet.gov.ar:11336/157329instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:13:16.329CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
title |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
spellingShingle |
Boron biodistribution study in colorectal liver metastases patients in Argentina Cardoso Cúneo, Jorge Eduardo Carlos Boron neutron capture therapy Unresectable colorectal liver metastases 10B biodistribution Hepatic autograft |
title_short |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
title_full |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
title_fullStr |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
title_full_unstemmed |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
title_sort |
Boron biodistribution study in colorectal liver metastases patients in Argentina |
dc.creator.none.fl_str_mv |
Cardoso Cúneo, Jorge Eduardo Carlos Nievas, S. Pereira, M. Schwint, Amanda Elena Trivillin, Verónica Andrea Pozzi, Emiliano César Cayetano Heber, Elisa Mercedes Monti Hughes, Andrea Sanchez, P. Bumaschny, E. Itoiz, María Elina Liberman, Susana Alcira |
author |
Cardoso Cúneo, Jorge Eduardo Carlos |
author_facet |
Cardoso Cúneo, Jorge Eduardo Carlos Nievas, S. Pereira, M. Schwint, Amanda Elena Trivillin, Verónica Andrea Pozzi, Emiliano César Cayetano Heber, Elisa Mercedes Monti Hughes, Andrea Sanchez, P. Bumaschny, E. Itoiz, María Elina Liberman, Susana Alcira |
author_role |
author |
author2 |
Nievas, S. Pereira, M. Schwint, Amanda Elena Trivillin, Verónica Andrea Pozzi, Emiliano César Cayetano Heber, Elisa Mercedes Monti Hughes, Andrea Sanchez, P. Bumaschny, E. Itoiz, María Elina Liberman, Susana Alcira |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Boron neutron capture therapy Unresectable colorectal liver metastases 10B biodistribution Hepatic autograft |
topic |
Boron neutron capture therapy Unresectable colorectal liver metastases 10B biodistribution Hepatic autograft |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible. Fil: Cardoso Cúneo, Jorge Eduardo Carlos. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Nievas, S.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; Argentina Fil: Pereira, M.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Trivillin, Verónica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina Fil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Heber, Elisa Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina Fil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Sanchez, P.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Bumaschny, E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina Fil: Itoiz, María Elina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Liberman, Susana Alcira. Comisión Nacional de Energía Atómica; Argentina |
description |
Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/157329 Cardoso Cúneo, Jorge Eduardo Carlos; Nievas, S.; Pereira, M.; Schwint, Amanda Elena; Trivillin, Verónica Andrea; et al.; Boron biodistribution study in colorectal liver metastases patients in Argentina; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-2009; 76-79 0969-8043 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/157329 |
identifier_str_mv |
Cardoso Cúneo, Jorge Eduardo Carlos; Nievas, S.; Pereira, M.; Schwint, Amanda Elena; Trivillin, Verónica Andrea; et al.; Boron biodistribution study in colorectal liver metastases patients in Argentina; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 67; 7-2009; 76-79 0969-8043 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969804309002504 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2009.03.021 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846083280630185984 |
score |
13.22299 |