The timing of neuronal development in adult hippocampal neurogenesis.

Autores
Piatti, Veronica del Carmen; Esposito, Maria Soledad; Schinder, Alejandro Fabián
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons of different ages because a significant proportion of neurons continues to be generated throughout life. The subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to produce functional dentate granule cells (DGCs) that become incorporated into the existing hippocampal circuitry. New available tools to identify adult-born neurons in live and fixed brain sections have allowed the transition from NPC to functional neuron to be characterized in great detail. Maturation of the neuronal phenotype includes changes in membrane excitability and morphology as well as the establishment of appropriate connectivity within the existing circuits, a process that lasts several weeks. The events leading to neuronal maturation share many of the features of the developing brain, and electrical activity is emerging as a key modulator of neuronal development in the adult DG. The underlying mechanisms are now beginning to be understood.
Fil: Piatti, Veronica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Esposito, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Adult Hippocampus
Differentiation
Functional Integration
Neural Progenitor Cells
Stem Cells
Synaptogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42695
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The timing of neuronal development in adult hippocampal neurogenesis.Piatti, Veronica del CarmenEsposito, Maria SoledadSchinder, Alejandro FabiánAdult HippocampusDifferentiationFunctional IntegrationNeural Progenitor CellsStem CellsSynaptogenesisThe granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons of different ages because a significant proportion of neurons continues to be generated throughout life. The subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to produce functional dentate granule cells (DGCs) that become incorporated into the existing hippocampal circuitry. New available tools to identify adult-born neurons in live and fixed brain sections have allowed the transition from NPC to functional neuron to be characterized in great detail. Maturation of the neuronal phenotype includes changes in membrane excitability and morphology as well as the establishment of appropriate connectivity within the existing circuits, a process that lasts several weeks. The events leading to neuronal maturation share many of the features of the developing brain, and electrical activity is emerging as a key modulator of neuronal development in the adult DG. The underlying mechanisms are now beginning to be understood.Fil: Piatti, Veronica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Esposito, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaSAGE Publications2006-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42695Piatti, Veronica del Carmen; Esposito, Maria Soledad; Schinder, Alejandro Fabián; The timing of neuronal development in adult hippocampal neurogenesis.; SAGE Publications; Neuroscientist; 12; 6; 12-2006; 463-4681073-85841089-4098CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/1073858406293538info:eu-repo/semantics/altIdentifier/doi/10.1177/1073858406293538info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:26Zoai:ri.conicet.gov.ar:11336/42695instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:26.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The timing of neuronal development in adult hippocampal neurogenesis.
title The timing of neuronal development in adult hippocampal neurogenesis.
spellingShingle The timing of neuronal development in adult hippocampal neurogenesis.
Piatti, Veronica del Carmen
Adult Hippocampus
Differentiation
Functional Integration
Neural Progenitor Cells
Stem Cells
Synaptogenesis
title_short The timing of neuronal development in adult hippocampal neurogenesis.
title_full The timing of neuronal development in adult hippocampal neurogenesis.
title_fullStr The timing of neuronal development in adult hippocampal neurogenesis.
title_full_unstemmed The timing of neuronal development in adult hippocampal neurogenesis.
title_sort The timing of neuronal development in adult hippocampal neurogenesis.
dc.creator.none.fl_str_mv Piatti, Veronica del Carmen
Esposito, Maria Soledad
Schinder, Alejandro Fabián
author Piatti, Veronica del Carmen
author_facet Piatti, Veronica del Carmen
Esposito, Maria Soledad
Schinder, Alejandro Fabián
author_role author
author2 Esposito, Maria Soledad
Schinder, Alejandro Fabián
author2_role author
author
dc.subject.none.fl_str_mv Adult Hippocampus
Differentiation
Functional Integration
Neural Progenitor Cells
Stem Cells
Synaptogenesis
topic Adult Hippocampus
Differentiation
Functional Integration
Neural Progenitor Cells
Stem Cells
Synaptogenesis
dc.description.none.fl_txt_mv The granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons of different ages because a significant proportion of neurons continues to be generated throughout life. The subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to produce functional dentate granule cells (DGCs) that become incorporated into the existing hippocampal circuitry. New available tools to identify adult-born neurons in live and fixed brain sections have allowed the transition from NPC to functional neuron to be characterized in great detail. Maturation of the neuronal phenotype includes changes in membrane excitability and morphology as well as the establishment of appropriate connectivity within the existing circuits, a process that lasts several weeks. The events leading to neuronal maturation share many of the features of the developing brain, and electrical activity is emerging as a key modulator of neuronal development in the adult DG. The underlying mechanisms are now beginning to be understood.
Fil: Piatti, Veronica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Esposito, Maria Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description The granule cell layer (GCL) of the adult dentate gyrus (DG) is a heterogeneous structure formed by neurons of different ages because a significant proportion of neurons continues to be generated throughout life. The subgranular zone of the DG contains neural progenitor cells (NPCs) that divide, differentiate, and migrate to produce functional dentate granule cells (DGCs) that become incorporated into the existing hippocampal circuitry. New available tools to identify adult-born neurons in live and fixed brain sections have allowed the transition from NPC to functional neuron to be characterized in great detail. Maturation of the neuronal phenotype includes changes in membrane excitability and morphology as well as the establishment of appropriate connectivity within the existing circuits, a process that lasts several weeks. The events leading to neuronal maturation share many of the features of the developing brain, and electrical activity is emerging as a key modulator of neuronal development in the adult DG. The underlying mechanisms are now beginning to be understood.
publishDate 2006
dc.date.none.fl_str_mv 2006-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42695
Piatti, Veronica del Carmen; Esposito, Maria Soledad; Schinder, Alejandro Fabián; The timing of neuronal development in adult hippocampal neurogenesis.; SAGE Publications; Neuroscientist; 12; 6; 12-2006; 463-468
1073-8584
1089-4098
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42695
identifier_str_mv Piatti, Veronica del Carmen; Esposito, Maria Soledad; Schinder, Alejandro Fabián; The timing of neuronal development in adult hippocampal neurogenesis.; SAGE Publications; Neuroscientist; 12; 6; 12-2006; 463-468
1073-8584
1089-4098
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journals.sagepub.com/doi/abs/10.1177/1073858406293538
info:eu-repo/semantics/altIdentifier/doi/10.1177/1073858406293538
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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