Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Autores
Beckervordersandforth, Ruth; Ebert, Birgit; Schäffner, Iris; Moss, Jonathan; Fiebig, Christian; Shin, Jaehoon; Moore, Darcie L.; Ghosh, Laboni; Trinchero, Mariela Fernanda; Stockburger, Carola; Friedland, Kristina; Steib, Kathrin; von Wittgenstein, Julia; Keiner, Silke; Redecker, Christoph; Hölter, Sabine M.; Xiang, Wei; Wurst, Wolfgang; Jagasia, Ravi; Schinder, Alejandro Fabián; Ming, Guo-li; Toni, Nicolas; Jessberger, Sebastian; Song, Hongjun; Lie, D. Chichung
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells (NSCs). The identity of stage-specific metabolic programs and their impact on adult neurogenesis are largely unknown. We show that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. Together with the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these data link mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus.
Fil: Beckervordersandforth, Ruth. Universitat Erlangen-Nuremberg; Alemania
Fil: Ebert, Birgit. Universitat Erlangen-Nuremberg; Alemania. German Research Center for Environmental Health; Alemania
Fil: Schäffner, Iris. Universitat Erlangen-Nuremberg; Alemania
Fil: Moss, Jonathan. Universite de Lausanne; Suiza
Fil: Fiebig, Christian. Universitat Erlangen-Nuremberg; Alemania
Fil: Shin, Jaehoon. University Johns Hopkins; Estados Unidos
Fil: Moore, Darcie L.. Universitat Zurich; Suiza
Fil: Ghosh, Laboni. Universitat Zurich; Suiza
Fil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Stockburger, Carola. Universitat Erlangen-Nuremberg; Alemania
Fil: Friedland, Kristina. Universitat Erlangen-Nuremberg; Alemania
Fil: Steib, Kathrin. German Research Center for Environmental Health; Alemania
Fil: von Wittgenstein, Julia. Universitat Erlangen-Nuremberg; Alemania
Fil: Keiner, Silke. Universitat Jena; Alemania
Fil: Redecker, Christoph. Universitat Jena; Alemania
Fil: Hölter, Sabine M.. German Research Center for Environmental Health; Alemania
Fil: Xiang, Wei. Universitat Erlangen-Nuremberg; Alemania
Fil: Wurst, Wolfgang. German Research Center for Environmental Health; Alemania
Fil: Jagasia, Ravi. German Research Center for Environmental Health; Alemania. F. Hoffmann-La Roche Ltd; Suiza
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Ming, Guo-li. University Johns Hopkins; Estados Unidos
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
Fil: Jessberger, Sebastian. Universitat Zurich; Suiza
Fil: Song, Hongjun. University Johns Hopkins; Estados Unidos
Fil: Lie, D. Chichung. Universitat Erlangen-Nuremberg; Alemania
Materia
Adult Neurogenesis
Aging
Metabolism
Mitochondria
Stem Cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72881
Acceder
id CONICETDig_2aa9ffbbb762d0ce408875bba7d76d09
oai_identifier_str oai:ri.conicet.gov.ar:11336/72881
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal NeurogenesisBeckervordersandforth, RuthEbert, BirgitSchäffner, IrisMoss, JonathanFiebig, ChristianShin, JaehoonMoore, Darcie L.Ghosh, LaboniTrinchero, Mariela FernandaStockburger, CarolaFriedland, KristinaSteib, Kathrinvon Wittgenstein, JuliaKeiner, SilkeRedecker, ChristophHölter, Sabine M.Xiang, WeiWurst, WolfgangJagasia, RaviSchinder, Alejandro FabiánMing, Guo-liToni, NicolasJessberger, SebastianSong, HongjunLie, D. ChichungAdult NeurogenesisAgingMetabolismMitochondriaStem Cellshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells (NSCs). The identity of stage-specific metabolic programs and their impact on adult neurogenesis are largely unknown. We show that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. Together with the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these data link mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus.Fil: Beckervordersandforth, Ruth. Universitat Erlangen-Nuremberg; AlemaniaFil: Ebert, Birgit. Universitat Erlangen-Nuremberg; Alemania. German Research Center for Environmental Health; AlemaniaFil: Schäffner, Iris. Universitat Erlangen-Nuremberg; AlemaniaFil: Moss, Jonathan. Universite de Lausanne; SuizaFil: Fiebig, Christian. Universitat Erlangen-Nuremberg; AlemaniaFil: Shin, Jaehoon. University Johns Hopkins; Estados UnidosFil: Moore, Darcie L.. Universitat Zurich; SuizaFil: Ghosh, Laboni. Universitat Zurich; SuizaFil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Stockburger, Carola. Universitat Erlangen-Nuremberg; AlemaniaFil: Friedland, Kristina. Universitat Erlangen-Nuremberg; AlemaniaFil: Steib, Kathrin. German Research Center for Environmental Health; AlemaniaFil: von Wittgenstein, Julia. Universitat Erlangen-Nuremberg; AlemaniaFil: Keiner, Silke. Universitat Jena; AlemaniaFil: Redecker, Christoph. Universitat Jena; AlemaniaFil: Hölter, Sabine M.. German Research Center for Environmental Health; AlemaniaFil: Xiang, Wei. Universitat Erlangen-Nuremberg; AlemaniaFil: Wurst, Wolfgang. German Research Center for Environmental Health; AlemaniaFil: Jagasia, Ravi. German Research Center for Environmental Health; Alemania. F. Hoffmann-La Roche Ltd; SuizaFil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Ming, Guo-li. University Johns Hopkins; Estados UnidosFil: Toni, Nicolas. Universite de Lausanne; SuizaFil: Jessberger, Sebastian. Universitat Zurich; SuizaFil: Song, Hongjun. University Johns Hopkins; Estados UnidosFil: Lie, D. Chichung. Universitat Erlangen-Nuremberg; AlemaniaCell Press2017-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72881Beckervordersandforth, Ruth; Ebert, Birgit; Schäffner, Iris; Moss, Jonathan; Fiebig, Christian; et al.; Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis; Cell Press; Neuron; 93; 3; 2-2017; 560-573.e60896-6273CONICET DigitalCONICETenginfo:eu-repo/semantics/reference/doi/https://doi.org/10.1016/j.neuron.2017.03.008info:eu-repo/semantics/reference/doi/https://doi.org/10.1016/j.stem.2017.01.004info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300896/info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089662731630959Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2016.12.017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:58Zoai:ri.conicet.gov.ar:11336/72881instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:58.824CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
title Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
spellingShingle Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
Beckervordersandforth, Ruth
Adult Neurogenesis
Aging
Metabolism
Mitochondria
Stem Cells
title_short Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
title_full Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
title_fullStr Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
title_full_unstemmed Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
title_sort Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis
dc.creator.none.fl_str_mv Beckervordersandforth, Ruth
Ebert, Birgit
Schäffner, Iris
Moss, Jonathan
Fiebig, Christian
Shin, Jaehoon
Moore, Darcie L.
Ghosh, Laboni
Trinchero, Mariela Fernanda
Stockburger, Carola
Friedland, Kristina
Steib, Kathrin
von Wittgenstein, Julia
Keiner, Silke
Redecker, Christoph
Hölter, Sabine M.
Xiang, Wei
Wurst, Wolfgang
Jagasia, Ravi
Schinder, Alejandro Fabián
Ming, Guo-li
Toni, Nicolas
Jessberger, Sebastian
Song, Hongjun
Lie, D. Chichung
author Beckervordersandforth, Ruth
author_facet Beckervordersandforth, Ruth
Ebert, Birgit
Schäffner, Iris
Moss, Jonathan
Fiebig, Christian
Shin, Jaehoon
Moore, Darcie L.
Ghosh, Laboni
Trinchero, Mariela Fernanda
Stockburger, Carola
Friedland, Kristina
Steib, Kathrin
von Wittgenstein, Julia
Keiner, Silke
Redecker, Christoph
Hölter, Sabine M.
Xiang, Wei
Wurst, Wolfgang
Jagasia, Ravi
Schinder, Alejandro Fabián
Ming, Guo-li
Toni, Nicolas
Jessberger, Sebastian
Song, Hongjun
Lie, D. Chichung
author_role author
author2 Ebert, Birgit
Schäffner, Iris
Moss, Jonathan
Fiebig, Christian
Shin, Jaehoon
Moore, Darcie L.
Ghosh, Laboni
Trinchero, Mariela Fernanda
Stockburger, Carola
Friedland, Kristina
Steib, Kathrin
von Wittgenstein, Julia
Keiner, Silke
Redecker, Christoph
Hölter, Sabine M.
Xiang, Wei
Wurst, Wolfgang
Jagasia, Ravi
Schinder, Alejandro Fabián
Ming, Guo-li
Toni, Nicolas
Jessberger, Sebastian
Song, Hongjun
Lie, D. Chichung
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adult Neurogenesis
Aging
Metabolism
Mitochondria
Stem Cells
topic Adult Neurogenesis
Aging
Metabolism
Mitochondria
Stem Cells
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells (NSCs). The identity of stage-specific metabolic programs and their impact on adult neurogenesis are largely unknown. We show that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. Together with the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these data link mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus.
Fil: Beckervordersandforth, Ruth. Universitat Erlangen-Nuremberg; Alemania
Fil: Ebert, Birgit. Universitat Erlangen-Nuremberg; Alemania. German Research Center for Environmental Health; Alemania
Fil: Schäffner, Iris. Universitat Erlangen-Nuremberg; Alemania
Fil: Moss, Jonathan. Universite de Lausanne; Suiza
Fil: Fiebig, Christian. Universitat Erlangen-Nuremberg; Alemania
Fil: Shin, Jaehoon. University Johns Hopkins; Estados Unidos
Fil: Moore, Darcie L.. Universitat Zurich; Suiza
Fil: Ghosh, Laboni. Universitat Zurich; Suiza
Fil: Trinchero, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Stockburger, Carola. Universitat Erlangen-Nuremberg; Alemania
Fil: Friedland, Kristina. Universitat Erlangen-Nuremberg; Alemania
Fil: Steib, Kathrin. German Research Center for Environmental Health; Alemania
Fil: von Wittgenstein, Julia. Universitat Erlangen-Nuremberg; Alemania
Fil: Keiner, Silke. Universitat Jena; Alemania
Fil: Redecker, Christoph. Universitat Jena; Alemania
Fil: Hölter, Sabine M.. German Research Center for Environmental Health; Alemania
Fil: Xiang, Wei. Universitat Erlangen-Nuremberg; Alemania
Fil: Wurst, Wolfgang. German Research Center for Environmental Health; Alemania
Fil: Jagasia, Ravi. German Research Center for Environmental Health; Alemania. F. Hoffmann-La Roche Ltd; Suiza
Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Ming, Guo-li. University Johns Hopkins; Estados Unidos
Fil: Toni, Nicolas. Universite de Lausanne; Suiza
Fil: Jessberger, Sebastian. Universitat Zurich; Suiza
Fil: Song, Hongjun. University Johns Hopkins; Estados Unidos
Fil: Lie, D. Chichung. Universitat Erlangen-Nuremberg; Alemania
description Precise regulation of cellular metabolism is hypothesized to constitute a vital component of the developmental sequence underlying the life-long generation of hippocampal neurons from quiescent neural stem cells (NSCs). The identity of stage-specific metabolic programs and their impact on adult neurogenesis are largely unknown. We show that the adult hippocampal neurogenic lineage is critically dependent on the mitochondrial electron transport chain and oxidative phosphorylation machinery at the stage of the fast proliferating intermediate progenitor cell. Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurogenesis defects. Together with the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these data link mitochondrial complex function to efficient lineage progression of adult NSCs and identify mitochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus.
publishDate 2017
dc.date.none.fl_str_mv 2017-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72881
Beckervordersandforth, Ruth; Ebert, Birgit; Schäffner, Iris; Moss, Jonathan; Fiebig, Christian; et al.; Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis; Cell Press; Neuron; 93; 3; 2-2017; 560-573.e6
0896-6273
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72881
identifier_str_mv Beckervordersandforth, Ruth; Ebert, Birgit; Schäffner, Iris; Moss, Jonathan; Fiebig, Christian; et al.; Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis; Cell Press; Neuron; 93; 3; 2-2017; 560-573.e6
0896-6273
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/doi/https://doi.org/10.1016/j.neuron.2017.03.008
info:eu-repo/semantics/reference/doi/https://doi.org/10.1016/j.stem.2017.01.004
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300896/
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S089662731630959X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2016.12.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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