HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus

Autores
Nicolás Párraga, Sara; Gandini, Carolina Lia; Pimenoff, Ville N.; Alemany, Laia; de Sanjosé, Silvia; Bosch, F. Xavier; Bravo, Ignacio G.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-inducedanogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages presentin 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia,and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distributionof HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3,except in Asia, whereHPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accountedfor less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties).Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenita lcancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.
Fil: Nicolás Párraga, Sara. Instituto Catalán de Oncología; España
Fil: Gandini, Carolina Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Instituto Catalán de Oncología; España
Fil: Pimenoff, Ville N.. Instituto Catalán de Oncología; España
Fil: Alemany, Laia. Instituto Catalán de Oncología; España
Fil: de Sanjosé, Silvia. Instituto Catalán de Oncología; España
Fil: Bosch, F. Xavier. Instituto Catalán de Oncología; España
Fil: Bravo, Ignacio G.. Centre National de la Recherche Scientifique. Institut de Recherche Pour Le Developpement. Departement Societes Et Sante. Laboratorio de Genetique Et Evolution Des Maladies Infectieuses; Francia
Materia
ANOGENITAL CANCERS
PAPILLOMAVIRUS INFECTION AND CANCER
VIRAL DIVERSITY
VIRAL EVOLUTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105552
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/105552
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anusNicolás Párraga, SaraGandini, Carolina LiaPimenoff, Ville N.Alemany, Laiade Sanjosé, SilviaBosch, F. XavierBravo, Ignacio G.ANOGENITAL CANCERSPAPILLOMAVIRUS INFECTION AND CANCERVIRAL DIVERSITYVIRAL EVOLUTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-inducedanogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages presentin 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia,and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distributionof HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3,except in Asia, whereHPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accountedfor less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties).Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenita lcancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.Fil: Nicolás Párraga, Sara. Instituto Catalán de Oncología; EspañaFil: Gandini, Carolina Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Instituto Catalán de Oncología; EspañaFil: Pimenoff, Ville N.. Instituto Catalán de Oncología; EspañaFil: Alemany, Laia. Instituto Catalán de Oncología; EspañaFil: de Sanjosé, Silvia. Instituto Catalán de Oncología; EspañaFil: Bosch, F. Xavier. Instituto Catalán de Oncología; EspañaFil: Bravo, Ignacio G.. Centre National de la Recherche Scientifique. Institut de Recherche Pour Le Developpement. Departement Societes Et Sante. Laboratorio de Genetique Et Evolution Des Maladies Infectieuses; FranciaWiley2016-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105552Nicolás Párraga, Sara; Gandini, Carolina Lia; Pimenoff, Ville N.; Alemany, Laia; de Sanjosé, Silvia; et al.; HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus; Wiley; Cancer Medicine; 5; 10; 10-2016; 2909-29192045-7634CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cam4.870/fullinfo:eu-repo/semantics/altIdentifier/doi/10.1002/cam4.870info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:55:03Zoai:ri.conicet.gov.ar:11336/105552instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:55:03.535CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
title HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
spellingShingle HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
Nicolás Párraga, Sara
ANOGENITAL CANCERS
PAPILLOMAVIRUS INFECTION AND CANCER
VIRAL DIVERSITY
VIRAL EVOLUTION
title_short HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
title_full HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
title_fullStr HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
title_full_unstemmed HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
title_sort HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
dc.creator.none.fl_str_mv Nicolás Párraga, Sara
Gandini, Carolina Lia
Pimenoff, Ville N.
Alemany, Laia
de Sanjosé, Silvia
Bosch, F. Xavier
Bravo, Ignacio G.
author Nicolás Párraga, Sara
author_facet Nicolás Párraga, Sara
Gandini, Carolina Lia
Pimenoff, Ville N.
Alemany, Laia
de Sanjosé, Silvia
Bosch, F. Xavier
Bravo, Ignacio G.
author_role author
author2 Gandini, Carolina Lia
Pimenoff, Ville N.
Alemany, Laia
de Sanjosé, Silvia
Bosch, F. Xavier
Bravo, Ignacio G.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ANOGENITAL CANCERS
PAPILLOMAVIRUS INFECTION AND CANCER
VIRAL DIVERSITY
VIRAL EVOLUTION
topic ANOGENITAL CANCERS
PAPILLOMAVIRUS INFECTION AND CANCER
VIRAL DIVERSITY
VIRAL EVOLUTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-inducedanogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages presentin 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia,and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distributionof HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3,except in Asia, whereHPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accountedfor less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties).Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenita lcancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.
Fil: Nicolás Párraga, Sara. Instituto Catalán de Oncología; España
Fil: Gandini, Carolina Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Instituto Catalán de Oncología; España
Fil: Pimenoff, Ville N.. Instituto Catalán de Oncología; España
Fil: Alemany, Laia. Instituto Catalán de Oncología; España
Fil: de Sanjosé, Silvia. Instituto Catalán de Oncología; España
Fil: Bosch, F. Xavier. Instituto Catalán de Oncología; España
Fil: Bravo, Ignacio G.. Centre National de la Recherche Scientifique. Institut de Recherche Pour Le Developpement. Departement Societes Et Sante. Laboratorio de Genetique Et Evolution Des Maladies Infectieuses; Francia
description Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-inducedanogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages presentin 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia,and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distributionof HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3,except in Asia, whereHPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accountedfor less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties).Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenita lcancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.
publishDate 2016
dc.date.none.fl_str_mv 2016-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105552
Nicolás Párraga, Sara; Gandini, Carolina Lia; Pimenoff, Ville N.; Alemany, Laia; de Sanjosé, Silvia; et al.; HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus; Wiley; Cancer Medicine; 5; 10; 10-2016; 2909-2919
2045-7634
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105552
identifier_str_mv Nicolás Párraga, Sara; Gandini, Carolina Lia; Pimenoff, Ville N.; Alemany, Laia; de Sanjosé, Silvia; et al.; HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus; Wiley; Cancer Medicine; 5; 10; 10-2016; 2909-2919
2045-7634
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cam4.870/full
info:eu-repo/semantics/altIdentifier/doi/10.1002/cam4.870
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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