Angiotensin II type 1 receptor blockade in early cirrhosis

Autores
Castaño, Gustavo Osvaldo; Sookoian, Silvia Cristina
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We read with great interest the article by Debernardi-Venon and collaborators, evaluating the hemodynamic response and variations in serum markers of liver fibrosis of twelve months’ administration of candesartan in Child A/B cirrhotic patients without ascites [1]. The authors found that angiotensin II type 1 receptor (AT1R) blockade induced a significant decrease in portal pressure, assessed as hepatic venous pressure gradient (HVPG), with 25% of the patients showing a decrease greater than 20%. The authors also observed a significant correlation between the reductions in HVPG and serum concentrations of hyaluronic acid. In the aforementioned study, candesartan was well tolerated in compensated cirrhotics with low plasma renin activity. The lack of severe adverse reactions was also observed in a previous report of losartan in preascitic cirrhosis [2]. In our opinion the main strength of this study is the simultaneous evaluation of hemodynamic and antifibrotic effects of AT1R blockade in humans.
Fil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105948
Acceder
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spelling Angiotensin II type 1 receptor blockade in early cirrhosisCastaño, Gustavo OsvaldoSookoian, Silvia Cristinahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1We read with great interest the article by Debernardi-Venon and collaborators, evaluating the hemodynamic response and variations in serum markers of liver fibrosis of twelve months’ administration of candesartan in Child A/B cirrhotic patients without ascites [1]. The authors found that angiotensin II type 1 receptor (AT1R) blockade induced a significant decrease in portal pressure, assessed as hepatic venous pressure gradient (HVPG), with 25% of the patients showing a decrease greater than 20%. The authors also observed a significant correlation between the reductions in HVPG and serum concentrations of hyaluronic acid. In the aforementioned study, candesartan was well tolerated in compensated cirrhotics with low plasma renin activity. The lack of severe adverse reactions was also observed in a previous report of losartan in preascitic cirrhosis [2]. In our opinion the main strength of this study is the simultaneous evaluation of hemodynamic and antifibrotic effects of AT1R blockade in humans.Fil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaElsevier Science2007-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105948Castaño, Gustavo Osvaldo; Sookoian, Silvia Cristina; Angiotensin II type 1 receptor blockade in early cirrhosis; Elsevier Science; Journal of Hepatology; 47; 3; 9-2007; 426-4270168-8278CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.journal-of-hepatology.eu/article/S0168-8278(07)00351-0/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2007.06.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:14:05Zoai:ri.conicet.gov.ar:11336/105948instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:14:06.076CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Angiotensin II type 1 receptor blockade in early cirrhosis
title Angiotensin II type 1 receptor blockade in early cirrhosis
spellingShingle Angiotensin II type 1 receptor blockade in early cirrhosis
Castaño, Gustavo Osvaldo
title_short Angiotensin II type 1 receptor blockade in early cirrhosis
title_full Angiotensin II type 1 receptor blockade in early cirrhosis
title_fullStr Angiotensin II type 1 receptor blockade in early cirrhosis
title_full_unstemmed Angiotensin II type 1 receptor blockade in early cirrhosis
title_sort Angiotensin II type 1 receptor blockade in early cirrhosis
dc.creator.none.fl_str_mv Castaño, Gustavo Osvaldo
Sookoian, Silvia Cristina
author Castaño, Gustavo Osvaldo
author_facet Castaño, Gustavo Osvaldo
Sookoian, Silvia Cristina
author_role author
author2 Sookoian, Silvia Cristina
author2_role author
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We read with great interest the article by Debernardi-Venon and collaborators, evaluating the hemodynamic response and variations in serum markers of liver fibrosis of twelve months’ administration of candesartan in Child A/B cirrhotic patients without ascites [1]. The authors found that angiotensin II type 1 receptor (AT1R) blockade induced a significant decrease in portal pressure, assessed as hepatic venous pressure gradient (HVPG), with 25% of the patients showing a decrease greater than 20%. The authors also observed a significant correlation between the reductions in HVPG and serum concentrations of hyaluronic acid. In the aforementioned study, candesartan was well tolerated in compensated cirrhotics with low plasma renin activity. The lack of severe adverse reactions was also observed in a previous report of losartan in preascitic cirrhosis [2]. In our opinion the main strength of this study is the simultaneous evaluation of hemodynamic and antifibrotic effects of AT1R blockade in humans.
Fil: Castaño, Gustavo Osvaldo. Gobierno de la Ciudad de Buenos Aires. Hospital "Dr. Abel Zubizarreta"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
description We read with great interest the article by Debernardi-Venon and collaborators, evaluating the hemodynamic response and variations in serum markers of liver fibrosis of twelve months’ administration of candesartan in Child A/B cirrhotic patients without ascites [1]. The authors found that angiotensin II type 1 receptor (AT1R) blockade induced a significant decrease in portal pressure, assessed as hepatic venous pressure gradient (HVPG), with 25% of the patients showing a decrease greater than 20%. The authors also observed a significant correlation between the reductions in HVPG and serum concentrations of hyaluronic acid. In the aforementioned study, candesartan was well tolerated in compensated cirrhotics with low plasma renin activity. The lack of severe adverse reactions was also observed in a previous report of losartan in preascitic cirrhosis [2]. In our opinion the main strength of this study is the simultaneous evaluation of hemodynamic and antifibrotic effects of AT1R blockade in humans.
publishDate 2007
dc.date.none.fl_str_mv 2007-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105948
Castaño, Gustavo Osvaldo; Sookoian, Silvia Cristina; Angiotensin II type 1 receptor blockade in early cirrhosis; Elsevier Science; Journal of Hepatology; 47; 3; 9-2007; 426-427
0168-8278
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105948
identifier_str_mv Castaño, Gustavo Osvaldo; Sookoian, Silvia Cristina; Angiotensin II type 1 receptor blockade in early cirrhosis; Elsevier Science; Journal of Hepatology; 47; 3; 9-2007; 426-427
0168-8278
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.journal-of-hepatology.eu/article/S0168-8278(07)00351-0/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jhep.2007.06.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.891075

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