Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma

Autores
Ayerza, Miguel A; Muscolo, Domingo L.; Aponte Tinao, Luis A; Farfalli, German
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To determine whether inappropriate surgical procedures based on an initial misdiagnosis affected recurrence and survival rates, we retrospectively reviewed the surgical treatment and results of 117 patients with high-grade osteosarcomas treated from January 1, 1990 to December 31, 2000. Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion. Two of the nine patients had amputations and seven patients had limb-salvage procedures. Of the 108 patients who were not misdiagnosed, six patients had amputations and 102 patients had limb-salvage procedures. All patients received neoadjuvant therapy. Fifteen of the 117 patients had local recurrences. Patients who had erroneous surgical procedures based on the initial misdiagnosis of osteosarcoma had an increased risk of local recurrence and decreased 10-year survival rate. Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.
Fil: Ayerza, Miguel A. Hospital Italiano; Argentina
Fil: Muscolo, Domingo L.. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aponte Tinao, Luis A. Hospital Italiano; Argentina
Fil: Farfalli, German. Hospital Italiano; Argentina
Materia
Osteosarcoma
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/244121
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with OsteosarcomaAyerza, Miguel AMuscolo, Domingo L.Aponte Tinao, Luis AFarfalli, GermanOsteosarcomahttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3To determine whether inappropriate surgical procedures based on an initial misdiagnosis affected recurrence and survival rates, we retrospectively reviewed the surgical treatment and results of 117 patients with high-grade osteosarcomas treated from January 1, 1990 to December 31, 2000. Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion. Two of the nine patients had amputations and seven patients had limb-salvage procedures. Of the 108 patients who were not misdiagnosed, six patients had amputations and 102 patients had limb-salvage procedures. All patients received neoadjuvant therapy. Fifteen of the 117 patients had local recurrences. Patients who had erroneous surgical procedures based on the initial misdiagnosis of osteosarcoma had an increased risk of local recurrence and decreased 10-year survival rate. Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.Fil: Ayerza, Miguel A. Hospital Italiano; ArgentinaFil: Muscolo, Domingo L.. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aponte Tinao, Luis A. Hospital Italiano; ArgentinaFil: Farfalli, German. Hospital Italiano; ArgentinaLippincott Williams2006-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/244121Ayerza, Miguel A; Muscolo, Domingo L.; Aponte Tinao, Luis A; Farfalli, German; Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma; Lippincott Williams; Clinical Orthopaedics And Related Research.; 452; 11-2006; 231-2350009-921XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/01.blo.0000229314.58878.88info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:18Zoai:ri.conicet.gov.ar:11336/244121instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:18.832CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
title Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
spellingShingle Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
Ayerza, Miguel A
Osteosarcoma
title_short Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
title_full Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
title_fullStr Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
title_full_unstemmed Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
title_sort Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma
dc.creator.none.fl_str_mv Ayerza, Miguel A
Muscolo, Domingo L.
Aponte Tinao, Luis A
Farfalli, German
author Ayerza, Miguel A
author_facet Ayerza, Miguel A
Muscolo, Domingo L.
Aponte Tinao, Luis A
Farfalli, German
author_role author
author2 Muscolo, Domingo L.
Aponte Tinao, Luis A
Farfalli, German
author2_role author
author
author
dc.subject.none.fl_str_mv Osteosarcoma
topic Osteosarcoma
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To determine whether inappropriate surgical procedures based on an initial misdiagnosis affected recurrence and survival rates, we retrospectively reviewed the surgical treatment and results of 117 patients with high-grade osteosarcomas treated from January 1, 1990 to December 31, 2000. Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion. Two of the nine patients had amputations and seven patients had limb-salvage procedures. Of the 108 patients who were not misdiagnosed, six patients had amputations and 102 patients had limb-salvage procedures. All patients received neoadjuvant therapy. Fifteen of the 117 patients had local recurrences. Patients who had erroneous surgical procedures based on the initial misdiagnosis of osteosarcoma had an increased risk of local recurrence and decreased 10-year survival rate. Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.
Fil: Ayerza, Miguel A. Hospital Italiano; Argentina
Fil: Muscolo, Domingo L.. Hospital Italiano; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Aponte Tinao, Luis A. Hospital Italiano; Argentina
Fil: Farfalli, German. Hospital Italiano; Argentina
description To determine whether inappropriate surgical procedures based on an initial misdiagnosis affected recurrence and survival rates, we retrospectively reviewed the surgical treatment and results of 117 patients with high-grade osteosarcomas treated from January 1, 1990 to December 31, 2000. Nine patients had intralesional curettage performed at other institutions based on an erroneous diagnosis of a benign lesion. Two of the nine patients had amputations and seven patients had limb-salvage procedures. Of the 108 patients who were not misdiagnosed, six patients had amputations and 102 patients had limb-salvage procedures. All patients received neoadjuvant therapy. Fifteen of the 117 patients had local recurrences. Patients who had erroneous surgical procedures based on the initial misdiagnosis of osteosarcoma had an increased risk of local recurrence and decreased 10-year survival rate. Response to adjuvant therapy and the amount of previous violation of natural tumor barriers should be evaluated carefully before deciding surgical treatment.
publishDate 2006
dc.date.none.fl_str_mv 2006-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/244121
Ayerza, Miguel A; Muscolo, Domingo L.; Aponte Tinao, Luis A; Farfalli, German; Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma; Lippincott Williams; Clinical Orthopaedics And Related Research.; 452; 11-2006; 231-235
0009-921X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/244121
identifier_str_mv Ayerza, Miguel A; Muscolo, Domingo L.; Aponte Tinao, Luis A; Farfalli, German; Effect of Erroneous Surgical Procedures on Recurrence and Survival Rates for Patients with Osteosarcoma; Lippincott Williams; Clinical Orthopaedics And Related Research.; 452; 11-2006; 231-235
0009-921X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/01.blo.0000229314.58878.88
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614182710804480
score 13.070432

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