N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus

Autores
Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Agnese, Mariel
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.
Fil: Vallejo, Mariana Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Agnese, Mariel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Materia
HUPERZIA SAURURUS
N-DEMETHYL-SAUROXINE
ACETYLCHOLINESTERASE INHIBITION
SAUROXINE NMR TWO DIMENSIONAL DATA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/9663
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/9663
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururusVallejo, Mariana GuadalupeOrtega, María GabrielaCabrera, Jose LuisAgnese, MarielHUPERZIA SAURURUSN-DEMETHYL-SAUROXINEACETYLCHOLINESTERASE INHIBITIONSAUROXINE NMR TWO DIMENSIONAL DATAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.Fil: Vallejo, Mariana Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Agnese, Mariel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaElsevier2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/9663Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Agnese, Mariel; N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus; Elsevier; Tetrahedron Letters; 54; 38; 7-2013; 5197-52000040-4039enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.tetlet.2013.07.068info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0040403913012173info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:33Zoai:ri.conicet.gov.ar:11336/9663instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:33.813CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
title N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
spellingShingle N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
Vallejo, Mariana Guadalupe
HUPERZIA SAURURUS
N-DEMETHYL-SAUROXINE
ACETYLCHOLINESTERASE INHIBITION
SAUROXINE NMR TWO DIMENSIONAL DATA
title_short N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
title_full N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
title_fullStr N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
title_full_unstemmed N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
title_sort N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
dc.creator.none.fl_str_mv Vallejo, Mariana Guadalupe
Ortega, María Gabriela
Cabrera, Jose Luis
Agnese, Mariel
author Vallejo, Mariana Guadalupe
author_facet Vallejo, Mariana Guadalupe
Ortega, María Gabriela
Cabrera, Jose Luis
Agnese, Mariel
author_role author
author2 Ortega, María Gabriela
Cabrera, Jose Luis
Agnese, Mariel
author2_role author
author
author
dc.subject.none.fl_str_mv HUPERZIA SAURURUS
N-DEMETHYL-SAUROXINE
ACETYLCHOLINESTERASE INHIBITION
SAUROXINE NMR TWO DIMENSIONAL DATA
topic HUPERZIA SAURURUS
N-DEMETHYL-SAUROXINE
ACETYLCHOLINESTERASE INHIBITION
SAUROXINE NMR TWO DIMENSIONAL DATA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.
Fil: Vallejo, Mariana Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Agnese, Mariel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
description The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/9663
Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Agnese, Mariel; N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus; Elsevier; Tetrahedron Letters; 54; 38; 7-2013; 5197-5200
0040-4039
url http://hdl.handle.net/11336/9663
identifier_str_mv Vallejo, Mariana Guadalupe; Ortega, María Gabriela; Cabrera, Jose Luis; Agnese, Mariel; N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus; Elsevier; Tetrahedron Letters; 54; 38; 7-2013; 5197-5200
0040-4039
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tetlet.2013.07.068
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0040403913012173
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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