The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet

Autores
Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; Monti, Juan Alberto; Ronco, Maria Teresa; Frances, Daniel Eleazar Antonio; Wagner, Marcelo; Carnovale, Cristina Ester; Luquita, Alejandra Nora
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.
Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; Argentina
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Materia
BILIARY SECRETION
CHOLESTEROL-ENRICHED DIET
HEMORHEOLOGICAL PROPERTIES
HYPOCHOLESTEROLEMIC MARKED
HYPOTRIGLYCEREDEMIC
LIGARIA CUNEIFOLIA
PROANTHOCYANIDIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/148777

id CONICETDig_8975785b88814e3f47d6141968d5f51a
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched dietGonzálvez, José EnriqueGarcía, Gloria AngélicaGalliano, Sebastián ArielDominighini, AliciaUrli, Leda DianaMonti, Juan AlbertoRonco, Maria TeresaFrances, Daniel Eleazar AntonioWagner, MarceloCarnovale, Cristina EsterLuquita, Alejandra NoraBILIARY SECRETIONCHOLESTEROL-ENRICHED DIETHEMORHEOLOGICAL PROPERTIESHYPOCHOLESTEROLEMIC MARKEDHYPOTRIGLYCEREDEMICLIGARIA CUNEIFOLIAPROANTHOCYANIDINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; ArgentinaFil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; ArgentinaFil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; ArgentinaFil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaBentham Science Publishers2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148777Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-532212-3334CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1872214812666180223110859info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/160058/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:31Zoai:ri.conicet.gov.ar:11336/148777instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:31.573CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
title The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
spellingShingle The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
Gonzálvez, José Enrique
BILIARY SECRETION
CHOLESTEROL-ENRICHED DIET
HEMORHEOLOGICAL PROPERTIES
HYPOCHOLESTEROLEMIC MARKED
HYPOTRIGLYCEREDEMIC
LIGARIA CUNEIFOLIA
PROANTHOCYANIDIN
title_short The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
title_full The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
title_fullStr The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
title_full_unstemmed The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
title_sort The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
dc.creator.none.fl_str_mv Gonzálvez, José Enrique
García, Gloria Angélica
Galliano, Sebastián Ariel
Dominighini, Alicia
Urli, Leda Diana
Monti, Juan Alberto
Ronco, Maria Teresa
Frances, Daniel Eleazar Antonio
Wagner, Marcelo
Carnovale, Cristina Ester
Luquita, Alejandra Nora
author Gonzálvez, José Enrique
author_facet Gonzálvez, José Enrique
García, Gloria Angélica
Galliano, Sebastián Ariel
Dominighini, Alicia
Urli, Leda Diana
Monti, Juan Alberto
Ronco, Maria Teresa
Frances, Daniel Eleazar Antonio
Wagner, Marcelo
Carnovale, Cristina Ester
Luquita, Alejandra Nora
author_role author
author2 García, Gloria Angélica
Galliano, Sebastián Ariel
Dominighini, Alicia
Urli, Leda Diana
Monti, Juan Alberto
Ronco, Maria Teresa
Frances, Daniel Eleazar Antonio
Wagner, Marcelo
Carnovale, Cristina Ester
Luquita, Alejandra Nora
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv BILIARY SECRETION
CHOLESTEROL-ENRICHED DIET
HEMORHEOLOGICAL PROPERTIES
HYPOCHOLESTEROLEMIC MARKED
HYPOTRIGLYCEREDEMIC
LIGARIA CUNEIFOLIA
PROANTHOCYANIDIN
topic BILIARY SECRETION
CHOLESTEROL-ENRICHED DIET
HEMORHEOLOGICAL PROPERTIES
HYPOCHOLESTEROLEMIC MARKED
HYPOTRIGLYCEREDEMIC
LIGARIA CUNEIFOLIA
PROANTHOCYANIDIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.
Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; Argentina
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
description Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/148777
Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-53
2212-3334
CONICET Digital
CONICET
url http://hdl.handle.net/11336/148777
identifier_str_mv Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-53
2212-3334
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
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dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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