The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet
- Autores
- Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; Monti, Juan Alberto; Ronco, Maria Teresa; Frances, Daniel Eleazar Antonio; Wagner, Marcelo; Carnovale, Cristina Ester; Luquita, Alejandra Nora
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.
Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina
Fil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina
Fil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; Argentina
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina - Materia
-
BILIARY SECRETION
CHOLESTEROL-ENRICHED DIET
HEMORHEOLOGICAL PROPERTIES
HYPOCHOLESTEROLEMIC MARKED
HYPOTRIGLYCEREDEMIC
LIGARIA CUNEIFOLIA
PROANTHOCYANIDIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/148777
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oai:ri.conicet.gov.ar:11336/148777 |
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The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched dietGonzálvez, José EnriqueGarcía, Gloria AngélicaGalliano, Sebastián ArielDominighini, AliciaUrli, Leda DianaMonti, Juan AlbertoRonco, Maria TeresaFrances, Daniel Eleazar AntonioWagner, MarceloCarnovale, Cristina EsterLuquita, Alejandra NoraBILIARY SECRETIONCHOLESTEROL-ENRICHED DIETHEMORHEOLOGICAL PROPERTIESHYPOCHOLESTEROLEMIC MARKEDHYPOTRIGLYCEREDEMICLIGARIA CUNEIFOLIAPROANTHOCYANIDINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism.Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaFil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; ArgentinaFil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; ArgentinaFil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; ArgentinaFil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; ArgentinaFil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; ArgentinaBentham Science Publishers2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/148777Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-532212-3334CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1872214812666180223110859info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/160058/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:31Zoai:ri.conicet.gov.ar:11336/148777instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:31.573CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
title |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
spellingShingle |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet Gonzálvez, José Enrique BILIARY SECRETION CHOLESTEROL-ENRICHED DIET HEMORHEOLOGICAL PROPERTIES HYPOCHOLESTEROLEMIC MARKED HYPOTRIGLYCEREDEMIC LIGARIA CUNEIFOLIA PROANTHOCYANIDIN |
title_short |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
title_full |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
title_fullStr |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
title_full_unstemmed |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
title_sort |
The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet |
dc.creator.none.fl_str_mv |
Gonzálvez, José Enrique García, Gloria Angélica Galliano, Sebastián Ariel Dominighini, Alicia Urli, Leda Diana Monti, Juan Alberto Ronco, Maria Teresa Frances, Daniel Eleazar Antonio Wagner, Marcelo Carnovale, Cristina Ester Luquita, Alejandra Nora |
author |
Gonzálvez, José Enrique |
author_facet |
Gonzálvez, José Enrique García, Gloria Angélica Galliano, Sebastián Ariel Dominighini, Alicia Urli, Leda Diana Monti, Juan Alberto Ronco, Maria Teresa Frances, Daniel Eleazar Antonio Wagner, Marcelo Carnovale, Cristina Ester Luquita, Alejandra Nora |
author_role |
author |
author2 |
García, Gloria Angélica Galliano, Sebastián Ariel Dominighini, Alicia Urli, Leda Diana Monti, Juan Alberto Ronco, Maria Teresa Frances, Daniel Eleazar Antonio Wagner, Marcelo Carnovale, Cristina Ester Luquita, Alejandra Nora |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
BILIARY SECRETION CHOLESTEROL-ENRICHED DIET HEMORHEOLOGICAL PROPERTIES HYPOCHOLESTEROLEMIC MARKED HYPOTRIGLYCEREDEMIC LIGARIA CUNEIFOLIA PROANTHOCYANIDIN |
topic |
BILIARY SECRETION CHOLESTEROL-ENRICHED DIET HEMORHEOLOGICAL PROPERTIES HYPOCHOLESTEROLEMIC MARKED HYPOTRIGLYCEREDEMIC LIGARIA CUNEIFOLIA PROANTHOCYANIDIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism. Fil: Gonzálvez, José Enrique. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: García, Gloria Angélica. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Galliano, Sebastián Ariel. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Urli, Leda Diana. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina Fil: Monti, Juan Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina Fil: Frances, Daniel Eleazar Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas; Argentina Fil: Wagner, Marcelo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacobótanica; Argentina Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Fisiología Experimental. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental; Argentina Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Ciencias Médicas; Argentina |
description |
Background: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. Objective: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. Method: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days. Then, were separated in six experimental groups (n=5 each one), which were injected ip every 24 h with: 1) saline solution (control group, C) and 2) PLc, 3 mg/100 g body weight (treated group, C+PLc), during 3, 7 and 10 days. Group C presented an increase in plasma levels of Cho and Triglycerides (TG), and also, accumulation of hepatic lipid droplets. Also, cell shape and their corresponding morphological index (MI) were altered too. Results: The treatment with PLc at 3, 7 and 10 days produces a diminution in the plasma Cho, LDL-Cho and serum TG levels, accompanied by a diminution of the lipid accumulation in the liver. The rates of bile acid output in bile can explain the diminution of plasma Cho, evidencing that some of the enzymes involved in the cholesterol conversion into bile acids could be up regulated by the treatment with PLc, leading to the observed increase bile flow. PLc treatment leads to a diminution of plasma levels of Cho and TG. Conclusion: Essentially, the treatment with PLc, despite the duration produces a modification in hemorheological parameters approaching the values of the experimental group with standard diet. Plasma levels of Cho, LDL-Cho and TG represent selected markers to evaluate the effect of enriched extract from Ligaria cuneifolia. Further work is necessary to better evaluate the mechanisms by which PLc induces modifications in the lipids metabolism. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/148777 Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-53 2212-3334 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/148777 |
identifier_str_mv |
Gonzálvez, José Enrique; García, Gloria Angélica; Galliano, Sebastián Ariel; Dominighini, Alicia; Urli, Leda Diana; et al.; The enriched proanthocyanidin extract of Ligaria cuneifolia shows a marked hypocholesterolemic effect in rats fed with cholesterol-enriched diet; Bentham Science Publishers; Recent Patents on Endocrine, Metabolic and Immune Drug Discovery; 11; 1; 2-2018; 47-53 2212-3334 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.2174/1872214812666180223110859 info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/160058/article |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Bentham Science Publishers |
publisher.none.fl_str_mv |
Bentham Science Publishers |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613532142796800 |
score |
13.070432 |