Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies
- Autores
- Dominighini, Alicia; Ferrero, Mariana Cristina; Crossetti, D.; Ronco, Maria Teresa; Gonzalves, Jose; Urli, Leda; Wagner, Marcelo Luis; Gurni, Alberto Angel; Carnovale, Cristina Ester; Luquita, Alejandra Nora
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- It was demonstrated that Ligaria cuneifolia (Lc) crude extract increased blood viscosity and decreased plasma cholesterol in rats. In the present study, we analyzed the Lc proanthocyanidin enriched fraction (PLc) to determine if it is capable of altering the hemorheological parameters while diminishing the plasma cholesterol. In vivo studies in adult male Wistar rats, randomized in three groups (n = 6 each one) were performed: 1. Control: saline intraperitoneal (i.p.); 2. PLc 0.6 mg/100 g body weight (b.w.) i.p. and 3. PLc 3 mg/100 g b.w. i.p., every 24 hours during 3 days. In vitro studies: with blood obtained by cardiac puncture, separated in aliquots and incubated with: 1. Saline solution (Control); 2. PLc 0.1 mg/mL, and 3. PLc 1.0 mg/mL, equivalent to doses in vivo experiments. The results demonstrated that in vivo PLc 0.6 and PLc 3 reduced plasma cholesterol (Cho) and LDL-Cho. Neither blood nor plasma viscosity was altered. Decrease of plasma cholesterol could be due to an increase of cholesterol and bile salts excretion leading to an increase of bile flow. In vitro experiments showed a direct interaction of PLc, at high concentration, with the erythrocyte membrane, inducing a switch from discocyte to stomatocyte. Only, PLc without hepatic metabolism produces hemorheological changes. Thus, PLc in vivo might be a pharmacological agent capable of decreasing plasma cholesterol.
Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Ferrero, Mariana Cristina. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Crossetti, D.. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
Fil: Gonzalves, Jose. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina
Fil: Urli, Leda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Cs.fisiologicas; Argentina
Fil: Wagner, Marcelo Luis. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Gurni, Alberto Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina
Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina - Materia
-
Proanthocyanidina
Cholesterol
Blood-Viscocity - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/6102
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Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studiesDominighini, AliciaFerrero, Mariana CristinaCrossetti, D.Ronco, Maria TeresaGonzalves, JoseUrli, LedaWagner, Marcelo LuisGurni, Alberto AngelCarnovale, Cristina EsterLuquita, Alejandra NoraProanthocyanidinaCholesterolBlood-Viscocityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3It was demonstrated that Ligaria cuneifolia (Lc) crude extract increased blood viscosity and decreased plasma cholesterol in rats. In the present study, we analyzed the Lc proanthocyanidin enriched fraction (PLc) to determine if it is capable of altering the hemorheological parameters while diminishing the plasma cholesterol. In vivo studies in adult male Wistar rats, randomized in three groups (n = 6 each one) were performed: 1. Control: saline intraperitoneal (i.p.); 2. PLc 0.6 mg/100 g body weight (b.w.) i.p. and 3. PLc 3 mg/100 g b.w. i.p., every 24 hours during 3 days. In vitro studies: with blood obtained by cardiac puncture, separated in aliquots and incubated with: 1. Saline solution (Control); 2. PLc 0.1 mg/mL, and 3. PLc 1.0 mg/mL, equivalent to doses in vivo experiments. The results demonstrated that in vivo PLc 0.6 and PLc 3 reduced plasma cholesterol (Cho) and LDL-Cho. Neither blood nor plasma viscosity was altered. Decrease of plasma cholesterol could be due to an increase of cholesterol and bile salts excretion leading to an increase of bile flow. In vitro experiments showed a direct interaction of PLc, at high concentration, with the erythrocyte membrane, inducing a switch from discocyte to stomatocyte. Only, PLc without hepatic metabolism produces hemorheological changes. Thus, PLc in vivo might be a pharmacological agent capable of decreasing plasma cholesterol.Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaFil: Ferrero, Mariana Cristina. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaFil: Crossetti, D.. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaFil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); ArgentinaFil: Gonzalves, Jose. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaFil: Urli, Leda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Cs.fisiologicas; ArgentinaFil: Wagner, Marcelo Luis. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Gurni, Alberto Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); ArgentinaFil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Cs.medicas; ArgentinaIos Press2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6102Dominighini, Alicia; Ferrero, Mariana Cristina; Crossetti, D.; Ronco, Maria Teresa; Gonzalves, Jose; et al.; Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies; Ios Press; Clinical Hemorheology And Microcirculation; 60; 3; 8-2014; 317-3251386-0291enginfo:eu-repo/semantics/altIdentifier/url/http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1870info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-141870info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:59Zoai:ri.conicet.gov.ar:11336/6102instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:59.302CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
title |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
spellingShingle |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies Dominighini, Alicia Proanthocyanidina Cholesterol Blood-Viscocity |
title_short |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
title_full |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
title_fullStr |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
title_full_unstemmed |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
title_sort |
Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies |
dc.creator.none.fl_str_mv |
Dominighini, Alicia Ferrero, Mariana Cristina Crossetti, D. Ronco, Maria Teresa Gonzalves, Jose Urli, Leda Wagner, Marcelo Luis Gurni, Alberto Angel Carnovale, Cristina Ester Luquita, Alejandra Nora |
author |
Dominighini, Alicia |
author_facet |
Dominighini, Alicia Ferrero, Mariana Cristina Crossetti, D. Ronco, Maria Teresa Gonzalves, Jose Urli, Leda Wagner, Marcelo Luis Gurni, Alberto Angel Carnovale, Cristina Ester Luquita, Alejandra Nora |
author_role |
author |
author2 |
Ferrero, Mariana Cristina Crossetti, D. Ronco, Maria Teresa Gonzalves, Jose Urli, Leda Wagner, Marcelo Luis Gurni, Alberto Angel Carnovale, Cristina Ester Luquita, Alejandra Nora |
author2_role |
author author author author author author author author author |
dc.subject.none.fl_str_mv |
Proanthocyanidina Cholesterol Blood-Viscocity |
topic |
Proanthocyanidina Cholesterol Blood-Viscocity |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
It was demonstrated that Ligaria cuneifolia (Lc) crude extract increased blood viscosity and decreased plasma cholesterol in rats. In the present study, we analyzed the Lc proanthocyanidin enriched fraction (PLc) to determine if it is capable of altering the hemorheological parameters while diminishing the plasma cholesterol. In vivo studies in adult male Wistar rats, randomized in three groups (n = 6 each one) were performed: 1. Control: saline intraperitoneal (i.p.); 2. PLc 0.6 mg/100 g body weight (b.w.) i.p. and 3. PLc 3 mg/100 g b.w. i.p., every 24 hours during 3 days. In vitro studies: with blood obtained by cardiac puncture, separated in aliquots and incubated with: 1. Saline solution (Control); 2. PLc 0.1 mg/mL, and 3. PLc 1.0 mg/mL, equivalent to doses in vivo experiments. The results demonstrated that in vivo PLc 0.6 and PLc 3 reduced plasma cholesterol (Cho) and LDL-Cho. Neither blood nor plasma viscosity was altered. Decrease of plasma cholesterol could be due to an increase of cholesterol and bile salts excretion leading to an increase of bile flow. In vitro experiments showed a direct interaction of PLc, at high concentration, with the erythrocyte membrane, inducing a switch from discocyte to stomatocyte. Only, PLc without hepatic metabolism produces hemorheological changes. Thus, PLc in vivo might be a pharmacological agent capable of decreasing plasma cholesterol. Fil: Dominighini, Alicia. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina Fil: Ferrero, Mariana Cristina. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina Fil: Crossetti, D.. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina Fil: Ronco, Maria Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina Fil: Gonzalves, Jose. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina Fil: Urli, Leda. Universidad Nacional de Rosario. Facultad de Cs.bioquimicas y Farmaceuticas. Departamento de Cs.fisiologicas; Argentina Fil: Wagner, Marcelo Luis. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Gurni, Alberto Angel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Carnovale, Cristina Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Fisiología Experimental (i); Argentina Fil: Luquita, Alejandra Nora. Universidad Nacional de Rosario. Facultad de Cs.medicas; Argentina |
description |
It was demonstrated that Ligaria cuneifolia (Lc) crude extract increased blood viscosity and decreased plasma cholesterol in rats. In the present study, we analyzed the Lc proanthocyanidin enriched fraction (PLc) to determine if it is capable of altering the hemorheological parameters while diminishing the plasma cholesterol. In vivo studies in adult male Wistar rats, randomized in three groups (n = 6 each one) were performed: 1. Control: saline intraperitoneal (i.p.); 2. PLc 0.6 mg/100 g body weight (b.w.) i.p. and 3. PLc 3 mg/100 g b.w. i.p., every 24 hours during 3 days. In vitro studies: with blood obtained by cardiac puncture, separated in aliquots and incubated with: 1. Saline solution (Control); 2. PLc 0.1 mg/mL, and 3. PLc 1.0 mg/mL, equivalent to doses in vivo experiments. The results demonstrated that in vivo PLc 0.6 and PLc 3 reduced plasma cholesterol (Cho) and LDL-Cho. Neither blood nor plasma viscosity was altered. Decrease of plasma cholesterol could be due to an increase of cholesterol and bile salts excretion leading to an increase of bile flow. In vitro experiments showed a direct interaction of PLc, at high concentration, with the erythrocyte membrane, inducing a switch from discocyte to stomatocyte. Only, PLc without hepatic metabolism produces hemorheological changes. Thus, PLc in vivo might be a pharmacological agent capable of decreasing plasma cholesterol. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/6102 Dominighini, Alicia; Ferrero, Mariana Cristina; Crossetti, D.; Ronco, Maria Teresa; Gonzalves, Jose; et al.; Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies; Ios Press; Clinical Hemorheology And Microcirculation; 60; 3; 8-2014; 317-325 1386-0291 |
url |
http://hdl.handle.net/11336/6102 |
identifier_str_mv |
Dominighini, Alicia; Ferrero, Mariana Cristina; Crossetti, D.; Ronco, Maria Teresa; Gonzalves, Jose; et al.; Effects of proanthocyanidin enriched extract from Ligaria cuneifolia on plasma cholesterol and hemorheological parameters. In vivo and In vitro studies; Ios Press; Clinical Hemorheology And Microcirculation; 60; 3; 8-2014; 317-325 1386-0291 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1870 info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/10.3233/CH-141870 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Ios Press |
publisher.none.fl_str_mv |
Ios Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613798114099200 |
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13.070432 |