Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina

Autores
Byrne, Alana Brooke; Gutierrez, Francisco Guillermo; Bruno, Agostina Alejandra; Cordoba, María Teresa; Bono, María M.; Polack, Fernando Pedro; Talarico, Laura Beatriz; Quipildor, Marcelo Omar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations, and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs. Of 301 patients with laboratory-confirmed dengue, 37.9% presented dengue with warning signs. Although nearly half of all patients had secondary DENV infections, no severe dengue cases, or deaths were reported. Furthermore, no association was found between incidence of warning signs and pre-existing immunity to DENV. Pediatric patients were least likely to present warning signs and showed significantly decreased risk of fever, retro-orbital pain, arthalgia, diarrhea and thrombocytopenia, and higher risk of rash compared to older patients. Female patients of all ages were also at higher risk of developing several symptoms. The characterization of DENV-4 infection in humans, a DENV serotype recently reported in Argentina, revealed differences in clinical manifestations, laboratory parameters and the presence/absence of warning signs based on age group. Further investigation of these age-related differences should contribute to better assessment of dengue disease in at risk populations.
Fil: Byrne, Alana Brooke. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutierrez, Francisco Guillermo. Hospital San Vicente de Paul; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Bruno, Agostina Alejandra. Hospital San Vicente de Paul; Argentina
Fil: Cordoba, María Teresa. Hospital San Vicente de Paul; Argentina
Fil: Bono, María M.. Hospital San Vicente de Paul; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talarico, Laura Beatriz. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Quipildor, Marcelo Omar. Hospital San Vicente de Paul; Argentina
Materia
AGE-RELATED DIFFERENCES
DENGUE VIRUS
DISEASE OUTCOMES
EPIDEMIOLOGY
PEDIATRIC POPULATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/98544
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/98544
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in ArgentinaByrne, Alana BrookeGutierrez, Francisco GuillermoBruno, Agostina AlejandraCordoba, María TeresaBono, María M.Polack, Fernando PedroTalarico, Laura BeatrizQuipildor, Marcelo OmarAGE-RELATED DIFFERENCESDENGUE VIRUSDISEASE OUTCOMESEPIDEMIOLOGYPEDIATRIC POPULATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations, and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs. Of 301 patients with laboratory-confirmed dengue, 37.9% presented dengue with warning signs. Although nearly half of all patients had secondary DENV infections, no severe dengue cases, or deaths were reported. Furthermore, no association was found between incidence of warning signs and pre-existing immunity to DENV. Pediatric patients were least likely to present warning signs and showed significantly decreased risk of fever, retro-orbital pain, arthalgia, diarrhea and thrombocytopenia, and higher risk of rash compared to older patients. Female patients of all ages were also at higher risk of developing several symptoms. The characterization of DENV-4 infection in humans, a DENV serotype recently reported in Argentina, revealed differences in clinical manifestations, laboratory parameters and the presence/absence of warning signs based on age group. Further investigation of these age-related differences should contribute to better assessment of dengue disease in at risk populations.Fil: Byrne, Alana Brooke. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Gutierrez, Francisco Guillermo. Hospital San Vicente de Paul; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; ArgentinaFil: Bruno, Agostina Alejandra. Hospital San Vicente de Paul; ArgentinaFil: Cordoba, María Teresa. Hospital San Vicente de Paul; ArgentinaFil: Bono, María M.. Hospital San Vicente de Paul; ArgentinaFil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Talarico, Laura Beatriz. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Quipildor, Marcelo Omar. Hospital San Vicente de Paul; ArgentinaWiley-liss, Div John Wiley & Sons Inc2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/98544Byrne, Alana Brooke; Gutierrez, Francisco Guillermo; Bruno, Agostina Alejandra; Cordoba, María Teresa; Bono, María M.; et al.; Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 90; 2; 2-2018; 197-2030146-6615CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.24952info:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.24952info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:21:40Zoai:ri.conicet.gov.ar:11336/98544instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:21:40.992CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
title Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
spellingShingle Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
Byrne, Alana Brooke
AGE-RELATED DIFFERENCES
DENGUE VIRUS
DISEASE OUTCOMES
EPIDEMIOLOGY
PEDIATRIC POPULATION
title_short Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
title_full Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
title_fullStr Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
title_full_unstemmed Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
title_sort Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina
dc.creator.none.fl_str_mv Byrne, Alana Brooke
Gutierrez, Francisco Guillermo
Bruno, Agostina Alejandra
Cordoba, María Teresa
Bono, María M.
Polack, Fernando Pedro
Talarico, Laura Beatriz
Quipildor, Marcelo Omar
author Byrne, Alana Brooke
author_facet Byrne, Alana Brooke
Gutierrez, Francisco Guillermo
Bruno, Agostina Alejandra
Cordoba, María Teresa
Bono, María M.
Polack, Fernando Pedro
Talarico, Laura Beatriz
Quipildor, Marcelo Omar
author_role author
author2 Gutierrez, Francisco Guillermo
Bruno, Agostina Alejandra
Cordoba, María Teresa
Bono, María M.
Polack, Fernando Pedro
Talarico, Laura Beatriz
Quipildor, Marcelo Omar
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv AGE-RELATED DIFFERENCES
DENGUE VIRUS
DISEASE OUTCOMES
EPIDEMIOLOGY
PEDIATRIC POPULATION
topic AGE-RELATED DIFFERENCES
DENGUE VIRUS
DISEASE OUTCOMES
EPIDEMIOLOGY
PEDIATRIC POPULATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations, and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs. Of 301 patients with laboratory-confirmed dengue, 37.9% presented dengue with warning signs. Although nearly half of all patients had secondary DENV infections, no severe dengue cases, or deaths were reported. Furthermore, no association was found between incidence of warning signs and pre-existing immunity to DENV. Pediatric patients were least likely to present warning signs and showed significantly decreased risk of fever, retro-orbital pain, arthalgia, diarrhea and thrombocytopenia, and higher risk of rash compared to older patients. Female patients of all ages were also at higher risk of developing several symptoms. The characterization of DENV-4 infection in humans, a DENV serotype recently reported in Argentina, revealed differences in clinical manifestations, laboratory parameters and the presence/absence of warning signs based on age group. Further investigation of these age-related differences should contribute to better assessment of dengue disease in at risk populations.
Fil: Byrne, Alana Brooke. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Gutierrez, Francisco Guillermo. Hospital San Vicente de Paul; Argentina. Universidad Nacional de Tucumán. Facultad de Medicina; Argentina
Fil: Bruno, Agostina Alejandra. Hospital San Vicente de Paul; Argentina
Fil: Cordoba, María Teresa. Hospital San Vicente de Paul; Argentina
Fil: Bono, María M.. Hospital San Vicente de Paul; Argentina
Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Talarico, Laura Beatriz. Fundación para la Investigación en Infectología Infantil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Quipildor, Marcelo Omar. Hospital San Vicente de Paul; Argentina
description Infection by any of the four dengue virus (DENV) serotypes produces a wide spectrum of clinical illness in humans. Differences in clinical manifestation and severity have been associated with secondary heterologous infection, patient age, and virus serotype. In this context, this retrospective study sought to analyze the presentation of dengue in patients during the 2014 DENV-4 outbreak affecting the City of Orán, Salta Province, Argentina. Demographic data, clinical manifestations, and laboratory abnormalities of laboratory-confirmed dengue patients were compared between age groups and between patients with and without warning signs. Of 301 patients with laboratory-confirmed dengue, 37.9% presented dengue with warning signs. Although nearly half of all patients had secondary DENV infections, no severe dengue cases, or deaths were reported. Furthermore, no association was found between incidence of warning signs and pre-existing immunity to DENV. Pediatric patients were least likely to present warning signs and showed significantly decreased risk of fever, retro-orbital pain, arthalgia, diarrhea and thrombocytopenia, and higher risk of rash compared to older patients. Female patients of all ages were also at higher risk of developing several symptoms. The characterization of DENV-4 infection in humans, a DENV serotype recently reported in Argentina, revealed differences in clinical manifestations, laboratory parameters and the presence/absence of warning signs based on age group. Further investigation of these age-related differences should contribute to better assessment of dengue disease in at risk populations.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/98544
Byrne, Alana Brooke; Gutierrez, Francisco Guillermo; Bruno, Agostina Alejandra; Cordoba, María Teresa; Bono, María M.; et al.; Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 90; 2; 2-2018; 197-203
0146-6615
CONICET Digital
CONICET
url http://hdl.handle.net/11336/98544
identifier_str_mv Byrne, Alana Brooke; Gutierrez, Francisco Guillermo; Bruno, Agostina Alejandra; Cordoba, María Teresa; Bono, María M.; et al.; Age-associated differences in clinical manifestations and laboratory parameters during a dengue virus type 4 outbreak in Argentina; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 90; 2; 2-2018; 197-203
0146-6615
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.24952
info:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.24952
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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