HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy

Autores
Cordo Russo, Rosalia Ines; Piccioni, Flavia Valeria; Barrientos, Gabriela Laura; Mazzolini Rizzo, Guillermo Daniel; Klapp, Burghard F.; Alaniz, Laura Daniela; García, Mariana Gabriela; Blois, Sandra M.
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hyaluronan (HA) is a glycosaminoglycan component of the extracellular matrix, where it possesses functions in morphogenesis, tissue injury and repair, inflammation, and tumorigenesis. HA is synthesized by HA synthases (HAS) and is degraded by hyaluronidases (HYAL). Increased levels of HA in tumors, due to differential expression of HAS and HYAL, are related to tumor progression and metastasis. During pregnancy, changes in HA deposition and distribution indicate that HA participates in preparation of the endometrial stroma for reception of the embryo. While pregnancy is a physiological state and cancer a complex and unpredictable pathology, both trophoblast and tumor cells share some proliferative, invasive, and immune tolerance mechanisms that allow establishment of pregnancy and tumor progression. This indicates that the study of a physiological condition such as pregnancy could help to find novel cancer treatment strategies. Abnormal HA metabolism has been observed in cancer and pathologies of pregnancy, thus indicating that HA could be considered a key molecule, able to regulate these processes. This review discusses the role of HA in cancer and pregnancy: the study of similarities and differences between both models could lead to identification of new targets for treatment of tumors or pregnancy-associated pathologies.
Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Piccioni, Flavia Valeria. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrientos, Gabriela Laura. Charité - Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klapp, Burghard F.. Charité - Universitätsmedizin Berlin; Alemania
Fil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Blois, Sandra M.. Charité - Universitätsmedizin Berlin; Alemania
Materia
Hyaluronan
Cancer
Pregnancy
Hyaluronidase
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84226
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/84226
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancyCordo Russo, Rosalia InesPiccioni, Flavia ValeriaBarrientos, Gabriela LauraMazzolini Rizzo, Guillermo DanielKlapp, Burghard F.Alaniz, Laura DanielaGarcía, Mariana GabrielaBlois, Sandra M.HyaluronanCancerPregnancyHyaluronidasehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Hyaluronan (HA) is a glycosaminoglycan component of the extracellular matrix, where it possesses functions in morphogenesis, tissue injury and repair, inflammation, and tumorigenesis. HA is synthesized by HA synthases (HAS) and is degraded by hyaluronidases (HYAL). Increased levels of HA in tumors, due to differential expression of HAS and HYAL, are related to tumor progression and metastasis. During pregnancy, changes in HA deposition and distribution indicate that HA participates in preparation of the endometrial stroma for reception of the embryo. While pregnancy is a physiological state and cancer a complex and unpredictable pathology, both trophoblast and tumor cells share some proliferative, invasive, and immune tolerance mechanisms that allow establishment of pregnancy and tumor progression. This indicates that the study of a physiological condition such as pregnancy could help to find novel cancer treatment strategies. Abnormal HA metabolism has been observed in cancer and pathologies of pregnancy, thus indicating that HA could be considered a key molecule, able to regulate these processes. This review discusses the role of HA in cancer and pregnancy: the study of similarities and differences between both models could lead to identification of new targets for treatment of tumors or pregnancy-associated pathologies.Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Piccioni, Flavia Valeria. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrientos, Gabriela Laura. Charité - Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Klapp, Burghard F.. Charité - Universitätsmedizin Berlin; AlemaniaFil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Blois, Sandra M.. Charité - Universitätsmedizin Berlin; AlemaniaResearch Trends2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84226Cordo Russo, Rosalia Ines; Piccioni, Flavia Valeria; Barrientos, Gabriela Laura; Mazzolini Rizzo, Guillermo Daniel; Klapp, Burghard F.; et al.; HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy ; Research Trends; Current Trends in Immunology; 13; 12-2012; 81-940972-4567CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=13&tid=36&aid=3642&pub=2012&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:25Zoai:ri.conicet.gov.ar:11336/84226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:26.042CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
title HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
spellingShingle HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
Cordo Russo, Rosalia Ines
Hyaluronan
Cancer
Pregnancy
Hyaluronidase
title_short HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
title_full HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
title_fullStr HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
title_full_unstemmed HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
title_sort HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy
dc.creator.none.fl_str_mv Cordo Russo, Rosalia Ines
Piccioni, Flavia Valeria
Barrientos, Gabriela Laura
Mazzolini Rizzo, Guillermo Daniel
Klapp, Burghard F.
Alaniz, Laura Daniela
García, Mariana Gabriela
Blois, Sandra M.
author Cordo Russo, Rosalia Ines
author_facet Cordo Russo, Rosalia Ines
Piccioni, Flavia Valeria
Barrientos, Gabriela Laura
Mazzolini Rizzo, Guillermo Daniel
Klapp, Burghard F.
Alaniz, Laura Daniela
García, Mariana Gabriela
Blois, Sandra M.
author_role author
author2 Piccioni, Flavia Valeria
Barrientos, Gabriela Laura
Mazzolini Rizzo, Guillermo Daniel
Klapp, Burghard F.
Alaniz, Laura Daniela
García, Mariana Gabriela
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hyaluronan
Cancer
Pregnancy
Hyaluronidase
topic Hyaluronan
Cancer
Pregnancy
Hyaluronidase
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hyaluronan (HA) is a glycosaminoglycan component of the extracellular matrix, where it possesses functions in morphogenesis, tissue injury and repair, inflammation, and tumorigenesis. HA is synthesized by HA synthases (HAS) and is degraded by hyaluronidases (HYAL). Increased levels of HA in tumors, due to differential expression of HAS and HYAL, are related to tumor progression and metastasis. During pregnancy, changes in HA deposition and distribution indicate that HA participates in preparation of the endometrial stroma for reception of the embryo. While pregnancy is a physiological state and cancer a complex and unpredictable pathology, both trophoblast and tumor cells share some proliferative, invasive, and immune tolerance mechanisms that allow establishment of pregnancy and tumor progression. This indicates that the study of a physiological condition such as pregnancy could help to find novel cancer treatment strategies. Abnormal HA metabolism has been observed in cancer and pathologies of pregnancy, thus indicating that HA could be considered a key molecule, able to regulate these processes. This review discusses the role of HA in cancer and pregnancy: the study of similarities and differences between both models could lead to identification of new targets for treatment of tumors or pregnancy-associated pathologies.
Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Piccioni, Flavia Valeria. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Barrientos, Gabriela Laura. Charité - Universitätsmedizin Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klapp, Burghard F.. Charité - Universitätsmedizin Berlin; Alemania
Fil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Blois, Sandra M.. Charité - Universitätsmedizin Berlin; Alemania
description Hyaluronan (HA) is a glycosaminoglycan component of the extracellular matrix, where it possesses functions in morphogenesis, tissue injury and repair, inflammation, and tumorigenesis. HA is synthesized by HA synthases (HAS) and is degraded by hyaluronidases (HYAL). Increased levels of HA in tumors, due to differential expression of HAS and HYAL, are related to tumor progression and metastasis. During pregnancy, changes in HA deposition and distribution indicate that HA participates in preparation of the endometrial stroma for reception of the embryo. While pregnancy is a physiological state and cancer a complex and unpredictable pathology, both trophoblast and tumor cells share some proliferative, invasive, and immune tolerance mechanisms that allow establishment of pregnancy and tumor progression. This indicates that the study of a physiological condition such as pregnancy could help to find novel cancer treatment strategies. Abnormal HA metabolism has been observed in cancer and pathologies of pregnancy, thus indicating that HA could be considered a key molecule, able to regulate these processes. This review discusses the role of HA in cancer and pregnancy: the study of similarities and differences between both models could lead to identification of new targets for treatment of tumors or pregnancy-associated pathologies.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84226
Cordo Russo, Rosalia Ines; Piccioni, Flavia Valeria; Barrientos, Gabriela Laura; Mazzolini Rizzo, Guillermo Daniel; Klapp, Burghard F.; et al.; HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy ; Research Trends; Current Trends in Immunology; 13; 12-2012; 81-94
0972-4567
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84226
identifier_str_mv Cordo Russo, Rosalia Ines; Piccioni, Flavia Valeria; Barrientos, Gabriela Laura; Mazzolini Rizzo, Guillermo Daniel; Klapp, Burghard F.; et al.; HA in pathological and physiological processes: An overview of HA metabolism in cancer and pregnancy ; Research Trends; Current Trends in Immunology; 13; 12-2012; 81-94
0972-4567
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=13&tid=36&aid=3642&pub=2012&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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