Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface

Autores
Cordo Russo, Rosalia Ines; García, Mariana Gabriela; Barrientos, Gabriela Laura; Orsal, A. S.; Viola, M.; Moschansky, Petra; Ringel, F.; Passi, A.; Alaniz, Laura Daniela; Hajos, Silvia Elvira; Blois, Sandra M.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The remodelling of the endometrial architecture is fundamental to create a suitable environment for the establishment of pregnancy. During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit. Hyaluronan is a conspicuous component of the extracellular matrix, particularly in remodelling tissues undergoing regeneration and repair. During gestation, changes in HA deposition and distribution indicate that this molecule may participate in preparation of the endometrial stroma for reception and implantation of the embryo. However, little is known about the role of hyaluronan at the fetomaternal interface, specially regarding its influence in pregnancy outcome. In the present study we show increased decidual hyaluronan levels in spontaneous abortion compared with normal pregnancy mice on gestation day 7.5. Both in normal and pathologic pregnancies, high molecular size hyaluronan was found at the fetomaternal unit. However, hyaluronan metabolism (which results from the activity of hyaluronan synthases and hyaluronidases) seems to be altered in spontaneous abortion as shown by a decrease in Hyal-3 expression as well as by differences in hyaluronan molecular size spectrum. This alteration in hyaluronan metabolism in spontaneous abortion could explain its increased concentration observed in decidua and the abnormal distribution of hyaluronan around the embryo implantation crypt. Thus, increased decidual hyaluronan levels resulting from abnormal deposition and turn over may contribute to the pathogenesis of pregnancy failure.
Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
Fil: García, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Orsal, A. S.. Universität zu Berlin; Alemania
Fil: Viola, M.. Universita degli Studi dell’Insubria; Italia
Fil: Moschansky, Petra. Universität zu Berlin; Alemania
Fil: Ringel, F.. Universität zu Berlin; Alemania
Fil: Passi, A.. Universita degli Studi dell’Insubria; Italia
Fil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
Materia
Hyaluronan
Hyaluronan Molecular Size
Hyaluronan Synthases
Hyaluronidases
Murine Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24466
Acceder
id CONICETDig_5a2213049303db49caf40e964ebd87ae
oai_identifier_str oai:ri.conicet.gov.ar:11336/24466
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interfaceCordo Russo, Rosalia InesGarcía, Mariana GabrielaBarrientos, Gabriela LauraOrsal, A. S.Viola, M.Moschansky, PetraRingel, F.Passi, A.Alaniz, Laura DanielaHajos, Silvia ElviraBlois, Sandra M.HyaluronanHyaluronan Molecular SizeHyaluronan SynthasesHyaluronidasesMurine Pregnancyhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The remodelling of the endometrial architecture is fundamental to create a suitable environment for the establishment of pregnancy. During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit. Hyaluronan is a conspicuous component of the extracellular matrix, particularly in remodelling tissues undergoing regeneration and repair. During gestation, changes in HA deposition and distribution indicate that this molecule may participate in preparation of the endometrial stroma for reception and implantation of the embryo. However, little is known about the role of hyaluronan at the fetomaternal interface, specially regarding its influence in pregnancy outcome. In the present study we show increased decidual hyaluronan levels in spontaneous abortion compared with normal pregnancy mice on gestation day 7.5. Both in normal and pathologic pregnancies, high molecular size hyaluronan was found at the fetomaternal unit. However, hyaluronan metabolism (which results from the activity of hyaluronan synthases and hyaluronidases) seems to be altered in spontaneous abortion as shown by a decrease in Hyal-3 expression as well as by differences in hyaluronan molecular size spectrum. This alteration in hyaluronan metabolism in spontaneous abortion could explain its increased concentration observed in decidua and the abnormal distribution of hyaluronan around the embryo implantation crypt. Thus, increased decidual hyaluronan levels resulting from abnormal deposition and turn over may contribute to the pathogenesis of pregnancy failure.Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; AlemaniaFil: García, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; AlemaniaFil: Barrientos, Gabriela Laura. Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orsal, A. S.. Universität zu Berlin; AlemaniaFil: Viola, M.. Universita degli Studi dell’Insubria; ItaliaFil: Moschansky, Petra. Universität zu Berlin; AlemaniaFil: Ringel, F.. Universität zu Berlin; AlemaniaFil: Passi, A.. Universita degli Studi dell’Insubria; ItaliaFil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Blois, Sandra M.. Universität zu Berlin; AlemaniaElsevier2008-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24466Cordo Russo, Rosalia Ines; García, Mariana Gabriela; Barrientos, Gabriela Laura; Orsal, A. S.; Viola, M.; et al.; Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface; Elsevier; Placenta; 30; 1; 11-2008; 88-950143-40041532-3102CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.placentajournal.org/article/S0143-4004(08)00364-0/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.placenta.2008.10.013info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0143400408003640info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:45Zoai:ri.conicet.gov.ar:11336/24466instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:46.132CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
title Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
spellingShingle Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
Cordo Russo, Rosalia Ines
Hyaluronan
Hyaluronan Molecular Size
Hyaluronan Synthases
Hyaluronidases
Murine Pregnancy
title_short Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
title_full Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
title_fullStr Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
title_full_unstemmed Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
title_sort Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface
dc.creator.none.fl_str_mv Cordo Russo, Rosalia Ines
García, Mariana Gabriela
Barrientos, Gabriela Laura
Orsal, A. S.
Viola, M.
Moschansky, Petra
Ringel, F.
Passi, A.
Alaniz, Laura Daniela
Hajos, Silvia Elvira
Blois, Sandra M.
author Cordo Russo, Rosalia Ines
author_facet Cordo Russo, Rosalia Ines
García, Mariana Gabriela
Barrientos, Gabriela Laura
Orsal, A. S.
Viola, M.
Moschansky, Petra
Ringel, F.
Passi, A.
Alaniz, Laura Daniela
Hajos, Silvia Elvira
Blois, Sandra M.
author_role author
author2 García, Mariana Gabriela
Barrientos, Gabriela Laura
Orsal, A. S.
Viola, M.
Moschansky, Petra
Ringel, F.
Passi, A.
Alaniz, Laura Daniela
Hajos, Silvia Elvira
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hyaluronan
Hyaluronan Molecular Size
Hyaluronan Synthases
Hyaluronidases
Murine Pregnancy
topic Hyaluronan
Hyaluronan Molecular Size
Hyaluronan Synthases
Hyaluronidases
Murine Pregnancy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The remodelling of the endometrial architecture is fundamental to create a suitable environment for the establishment of pregnancy. During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit. Hyaluronan is a conspicuous component of the extracellular matrix, particularly in remodelling tissues undergoing regeneration and repair. During gestation, changes in HA deposition and distribution indicate that this molecule may participate in preparation of the endometrial stroma for reception and implantation of the embryo. However, little is known about the role of hyaluronan at the fetomaternal interface, specially regarding its influence in pregnancy outcome. In the present study we show increased decidual hyaluronan levels in spontaneous abortion compared with normal pregnancy mice on gestation day 7.5. Both in normal and pathologic pregnancies, high molecular size hyaluronan was found at the fetomaternal unit. However, hyaluronan metabolism (which results from the activity of hyaluronan synthases and hyaluronidases) seems to be altered in spontaneous abortion as shown by a decrease in Hyal-3 expression as well as by differences in hyaluronan molecular size spectrum. This alteration in hyaluronan metabolism in spontaneous abortion could explain its increased concentration observed in decidua and the abnormal distribution of hyaluronan around the embryo implantation crypt. Thus, increased decidual hyaluronan levels resulting from abnormal deposition and turn over may contribute to the pathogenesis of pregnancy failure.
Fil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
Fil: García, Mariana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Universität zu Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Orsal, A. S.. Universität zu Berlin; Alemania
Fil: Viola, M.. Universita degli Studi dell’Insubria; Italia
Fil: Moschansky, Petra. Universität zu Berlin; Alemania
Fil: Ringel, F.. Universität zu Berlin; Alemania
Fil: Passi, A.. Universita degli Studi dell’Insubria; Italia
Fil: Alaniz, Laura Daniela. Universidad Austral. Facultad de Ciencias Biomédicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Hajos, Silvia Elvira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
description The remodelling of the endometrial architecture is fundamental to create a suitable environment for the establishment of pregnancy. During this process, substantial alterations in the composition of maternal extracellular matrix play an important role by providing a prosperous medium for implantation as well as modulating trophoblast invasion leading to the formation of a functional placental unit. Hyaluronan is a conspicuous component of the extracellular matrix, particularly in remodelling tissues undergoing regeneration and repair. During gestation, changes in HA deposition and distribution indicate that this molecule may participate in preparation of the endometrial stroma for reception and implantation of the embryo. However, little is known about the role of hyaluronan at the fetomaternal interface, specially regarding its influence in pregnancy outcome. In the present study we show increased decidual hyaluronan levels in spontaneous abortion compared with normal pregnancy mice on gestation day 7.5. Both in normal and pathologic pregnancies, high molecular size hyaluronan was found at the fetomaternal unit. However, hyaluronan metabolism (which results from the activity of hyaluronan synthases and hyaluronidases) seems to be altered in spontaneous abortion as shown by a decrease in Hyal-3 expression as well as by differences in hyaluronan molecular size spectrum. This alteration in hyaluronan metabolism in spontaneous abortion could explain its increased concentration observed in decidua and the abnormal distribution of hyaluronan around the embryo implantation crypt. Thus, increased decidual hyaluronan levels resulting from abnormal deposition and turn over may contribute to the pathogenesis of pregnancy failure.
publishDate 2008
dc.date.none.fl_str_mv 2008-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24466
Cordo Russo, Rosalia Ines; García, Mariana Gabriela; Barrientos, Gabriela Laura; Orsal, A. S.; Viola, M.; et al.; Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface; Elsevier; Placenta; 30; 1; 11-2008; 88-95
0143-4004
1532-3102
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24466
identifier_str_mv Cordo Russo, Rosalia Ines; García, Mariana Gabriela; Barrientos, Gabriela Laura; Orsal, A. S.; Viola, M.; et al.; Murine abortion is associated with enhanced Hyaluronan expression and abnormal localization at the fetomaternal interface; Elsevier; Placenta; 30; 1; 11-2008; 88-95
0143-4004
1532-3102
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.placentajournal.org/article/S0143-4004(08)00364-0/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.placenta.2008.10.013
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0143400408003640
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614292088815616
score 13.070432

Publicaciones similares